2004-09 to 2008-07 PhD: Institute of Physics, Chinese Academy of Sciences
2016-08 to Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
2011-08 to 2016-06 - Institute of Microbiology, Chinese Academy of Sciences - Associate Researcher
2008-07 to 2011-08 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
Clarivate Highly Cited Researcher (2023): Other
World's Top 2% Scientists (2023): Other
Clarivate Highly Cited Researcher (2022): Other
Clarivate Highly Cited Researcher (2021): Other
Chinese Preventive Medicine Association Science and Technology Award (2017): First Prize, Ministerial Level
Beijing Science and Technology Award (2011): First Prize, Provincial Level
Research
Molecular mechanisms of pathogenic microorganisms invading host cells Design of vaccines based on dominant epitopes Design of inhibitors
A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease, JOURNAL OF IMMUNOLOGY, 2023
Cryo-EM structure of severe fever with thrombocytopenia syndrome virus, NATURE COMMUNICATIONS, 2023
Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly, NATURE COMMUNICATIONS, 2023
In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein, ACS CENTRAL SCIENCE, 2023
Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023
Structure of monkeypox virus DNA polymerase holoenzyme, SCIENCE, 2023
The mechanism of STING autoinhibition and activation, MOLECULAR CELL, 2023
Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer, MABS, 2023
An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB, CELL REPORTS MEDICINE, 2023
Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs, EMBO JOURNAL, 2023
Molecular mechanism of de novo replication by the Ebola virus polymerase, Nature, 2023
Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2, CELL, 2022
VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes, NUCLEIC ACIDS RESEARCH, 2022
Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1, CELL, 2022
Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants, JOURNAL OF VIROLOGY, 2022
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2, CELL, 2022
Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3, IMMUNITY, 2022
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals, NATIONAL SCIENCE REVIEW, 2022
Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses, NATURE COMMUNICATIONS, 2022
Structure of the Ebola virus polymerase complex, NATURE, 2022
Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape, NATURE COMMUNICATIONS, 2022
Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes, Nature Communications, 2022
Application of an Integrated Platform for Basic and Applied Research in the Prevention and Control of the COVID-19 Pandemic, 中国科学基金, 2022
Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous beta 2-Microglobulin, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021
Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, 创新(英文), 2021
Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin, EMBO JOURNAL, 2021
The molecular basis for SARS-CoV-2 binding to dog ACE2, NATURE COMMUNICATIONS, 2021
Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1, CELL REPORTS, 2021
Structure-based design of 5 '-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors, RSC ADVANCES, 2021
Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation, CELL REPORTS, 2021
新型冠状病毒结合穿山甲ACE2受体的分子机制, 科学通报, 2021
Cross-species recognition of SARS-CoV-2 to bat ACE2, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021
Human group A rotavirus P25 VP8* specifically binds to A-type histo-blood group antigen, VIROLOGY, 2021
Cell entry by SARS-CoV-2, TRENDS IN BIOCHEMICAL SCIENCES, 2021
Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch, NATURE IMMUNOLOGY, 2021
Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants, NATURE COMMUNICATIONS, 2021
Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2, ISCIENCE, 2021
Crystal structure of the African swine fever virus core shell protein p15, 生物安全与健康(英文), 2021
Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species, CELL, 2021
A broadly protective antibody that targets the flavivirus NS1 protein, SCIENCE, 2021
Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals, NATURE MICROBIOLOGY, 2021
Crystal structure of the African swine fever virus core shell protein p15, BIOSAFETY AND HEALTH, 2021
Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020
Structural insight into arenavirus replication machinery, NATURE, 2020
Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species, FRONTIERS IN VETERINARY SCIENCE, 2020
Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex, CELLULAR & MOLEC
Keywords
Pathogenic MicroorganismsHost CellsMolecular MechanismsVaccinesDominant EpitopesInhibitorsNanoparticle VaccineAntibodiesEnzyme InhibitorsPathogen Control
