Areas of Focus
- Pathogen Infection Regulation and Intervention
- Research on Interaction Mechanisms of Immune Cell Receptors and Ligands
Work Experience
- 2018-07~Present - Institute of Microbiology, Chinese Academy of Sciences - Deputy Director of Pathogen Room, Researcher
- 2016-03~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
- 2013-08~2016-02 - Beijing Institute of Life Sciences, Chinese Academy of Sciences - Associate Researcher
- 2013-03~2013-07 - Beijing Institute of Life Sciences, Chinese Academy of Sciences - Assistant Researcher
- 2011-07~2013-02 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2006-09--2011-06 Ph.D.: Institute of Microbiology, Chinese Academy of Sciences
- 2002-10--2006-07 Bachelor's: College of Life Sciences, Zhejiang University
Publications
- Structure of monkeypox virus DNA polymerase holoenzyme, 11th Author, 2023
- Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer, 11th Author, 2023
- Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease, 11th Author, 2023
- Molecular mechanism of de novo replication by the Ebola virus polymerase, Not mentioned, 2023
- Structure of the Ebola virus polymerase complex, 11th Author, 2022
- SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape, 20th Author, 2021
- Thoughts on Basic Research to Practical Application: Case Study on CAS Key Laboratory of Pathogenic Microbiology and Immunology, 1st Author, 2021
- Microbial Evolution of Cryosphere and Biosecurity Concerns, 3rd Author, 2021
- Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, 11th Author, 2021
- Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost, 11th Author, 2021
- Avian influenza A(H7N9) virus: from low pathogenic to highly pathogenic, 8th Author, 2021
- Molecular mechanism of SARS-CoV-2 binding to pangolin ACE2 receptor, 7th Author, 2021
- A broadly protective antibody that targets the flavivirus NS1 protein, 11th Author, 2021
- Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals, 11th Author, 2021
- Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, 11th Author, 2021
- The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro, 9th Author, 2020
- Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, 12th Author, 2020
- Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients, 35th Author, 2020
- Structural insight into arenavirus replication machinery, 11th Author, 2020
- Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex, 9th Author, 2020
- Diversity and abundance of resistome in rhizosphere soil, 11th Author, 2020
- Cryo-EM structure of the varicella-zoster virus A-capsid, 7th Author, 2020
- Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2, 11th Author, 2020
- Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus, Not mentioned, 2020
- Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy- d - arabino- heptulosonate-7-phosphate synthase from Escherichia coli, Not mentioned, 2019
- Expression and Purification of C-terminal of Arenavirus Polymerase and Screening of Crystallization Conditions, 5th Author, 2019
- Structural insight into RNA synthesis by influenza D polymerase, 11th Author, 2019
- Cryo-EM Structure of the African Swine Fever Virus, 11th Author, 2019
- Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein, 16th Author, 2019
- Neutralization mechanism of human monoclonal antibodies against rift valley fever virus, 22nd Author, 2019
- Antibiotic resistance gene reservoir in live poultry markets, 8th Author, 2019
- Intact Glycopeptide Analysis of Influenza A/H1N1/09 Neuraminidase Revealing the Effects of Host and Glycosite Location on Site-Specific Glycan Structures, 11th Author, 2019
- Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses, 20th Author, 2019
- Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin, 14th Author, 2019
- Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B, 23rd Author, 2019
- Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans, 11th Author, 2019
- Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4, 11th Author, 2019
- Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope, 19th Author, 2019
- Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development, 19th Author, 2019
- Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation, 7th Author, 2019
- Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein, 11th Author, 2018
- An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques
Awards
- Global Highly Cited Scientist (2023): Other
- Global Highly Cited Scientist (2022): Other
- Qiu Shi Outstanding Scientific Achievement Collective Award (2019): Other
- Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2019): Institute Level
- Fourth 'Rising Star' Compound Talent Award, Beijing Branch, Chinese Academy of Sciences (2018): Institute Level
- Science and Technology Award of the Chinese Preventive Medicine Association (2017): First Prize, Other
- Zhongyuan Concord Life Medicine Innovation Breakthrough Award (2016): Other
- National Excellent Youth Fund Support (2016): National Level
- Top Ten Advances in Life Sciences in China (2016): Other
- Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2015): Institute Level
- Lu Jiaxi Youth Talent Award, Chinese Academy of Sciences (2014): Institute Level
- Outstanding Young Scientist Support Project, Chinese Academy of Sciences (2014): Institute Level
