Professor | Liangliang Wang | Asia Growth Partners

Name	Liangliang Wang
Contact Information	wangliangliang@mail.kib.ac.cn
Language ability	Chinese, English, German, French
Province	Yunnan

Name

Liangliang Wang

Contact Information

wangliangliang@mail.kib.ac.cn

Language ability

Chinese, English, German, French

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2007-09--2012-07 PhD: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences 2003-09--2007-07 Bachelor of Science: Anhui University
Work Experience	2023.06-present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher 2017.03-2023.05 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher 2013-12-2016-12 - Leibniz Universität Hannover - Postdoctoral Researcher 2013-11-2014-11 - École Polytechnique - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2007-09--2012-07 PhD: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
2003-09--2007-07 Bachelor of Science: Anhui University

Work Experience

2023.06-present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
2017.03-2023.05 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
2013-12-2016-12 - Leibniz Universität Hannover - Postdoctoral Researcher
2013-11-2014-11 - École Polytechnique - Postdoctoral Researcher

Areas of Focus	Total synthesis of bioactive natural products and medicinal chemistry Asymmetric synthesis methodologies based on metal or small organic molecule catalysis
Publications	Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A, Chinese Journal of Organic Chemistry, 2024 Chiral phosphoric acid catalyzed enantioselective inverse-electron-demand oxa-Diels-Alder reactions to synthesize chiral tricyclic tetrahydropyran derivatives, ORGANIC CHEMISTRY FRONTIERS, 2023 Asymmetric Total Synthesis of Antibiotic Elansolid A, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022 Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction, NATURE COMMUNICATIONS, 2021 An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of Cathepsin L: KGP94, Bioorganic Chemistry, 2021 Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, Chinese Journal of Organic Chemistry, 2021 Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation, Computational Biology and Chemistry, 2021 An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94, BIOORGANIC CHEMISTRY, 2021 Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, 有机化学, 2021 The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020 Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020 Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists, Computational Biology and Chemistry, 2019 Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study, Computational Biology and Chemistry, 2019 Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer invitro and invivo, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019 Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists, COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019 Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins, ADV. SYNTH. CATAL, 2018 A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocinconjugates for use in magnet drug targeting, Chem. Eur. J., 2017 Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1, CHEMISTRY-A EUROPEAN JOURNAL, 2017 Organocatalytic stereocontrolled synthesis of 3,3 '-pyrrolidinyl spirooxindoles by 3+2 annulation of isocyanoesters with methyleneindolinones, CHEMICAL COMMUNICATIONS, 2012 A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2011 Highly organocatalytic asymmetric michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2010

Areas of Focus

Total synthesis of bioactive natural products and medicinal chemistry
Asymmetric synthesis methodologies based on metal or small organic molecule catalysis

Publications

Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A, Chinese Journal of Organic Chemistry, 2024
Chiral phosphoric acid catalyzed enantioselective inverse-electron-demand oxa-Diels-Alder reactions to synthesize chiral tricyclic tetrahydropyran derivatives, ORGANIC CHEMISTRY FRONTIERS, 2023
Asymmetric Total Synthesis of Antibiotic Elansolid A, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022
Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction, NATURE COMMUNICATIONS, 2021
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of Cathepsin L: KGP94, Bioorganic Chemistry, 2021
Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, Chinese Journal of Organic Chemistry, 2021
Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation, Computational Biology and Chemistry, 2021
An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94, BIOORGANIC CHEMISTRY, 2021
Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, 有机化学, 2021
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020
Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists, Computational Biology and Chemistry, 2019
Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study, Computational Biology and Chemistry, 2019
Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer invitro and invivo, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019
Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists, COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019
Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins, ADV. SYNTH. CATAL, 2018
A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocinconjugates for use in magnet drug targeting, Chem. Eur. J., 2017
Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1, CHEMISTRY-A EUROPEAN JOURNAL, 2017
Organocatalytic stereocontrolled synthesis of 3,3 '-pyrrolidinyl spirooxindoles by 3+2 annulation of isocyanoesters with methyleneindolinones, CHEMICAL COMMUNICATIONS, 2012
A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2011
Highly organocatalytic asymmetric michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2010

Natural Products Total Synthesis Medicinal Chemistry Antibiotics Asymmetric Synthesis Metal Catalysis Organic Catalysis Chiral Synthesis Drug Candidates Structure Optimization

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