Areas of Focus
- Total synthesis of bioactive natural products and medicinal chemistry
- Asymmetric synthesis methodologies based on metal or small organic molecule catalysis
Work Experience
- 2023.06-present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
- 2017.03-2023.05 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
- 2013-12-2016-12 - Leibniz Universität Hannover - Postdoctoral Researcher
- 2013-11-2014-11 - École Polytechnique - Postdoctoral Researcher
Academic Background & Achievements
- 2007-09--2012-07 PhD: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
- 2003-09--2007-07 Bachelor of Science: Anhui University
Publications
- Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A, Chinese Journal of Organic Chemistry, 2024
- Chiral phosphoric acid catalyzed enantioselective inverse-electron-demand oxa-Diels-Alder reactions to synthesize chiral tricyclic tetrahydropyran derivatives, ORGANIC CHEMISTRY FRONTIERS, 2023
- Asymmetric Total Synthesis of Antibiotic Elansolid A, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022
- Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction, NATURE COMMUNICATIONS, 2021
- An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of Cathepsin L: KGP94, Bioorganic Chemistry, 2021
- Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, Chinese Journal of Organic Chemistry, 2021
- Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation, Computational Biology and Chemistry, 2021
- An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94, BIOORGANIC CHEMISTRY, 2021
- Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, 有机化学, 2021
- The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
- Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020
- Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists, Computational Biology and Chemistry, 2019
- Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study, Computational Biology and Chemistry, 2019
- Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer invitro and invivo, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019
- Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists, COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019
- Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins, ADV. SYNTH. CATAL, 2018
- A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocinconjugates for use in magnet drug targeting, Chem. Eur. J., 2017
- Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1, CHEMISTRY-A EUROPEAN JOURNAL, 2017
- Organocatalytic stereocontrolled synthesis of 3,3 '-pyrrolidinyl spirooxindoles by 3+2 annulation of isocyanoesters with methyleneindolinones, CHEMICAL COMMUNICATIONS, 2012
- A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2011
- Highly organocatalytic asymmetric michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2010
