汪亮亮
wangliangliang@mail.kib.ac.cn
中文, 英语, 德语, 法语
云南
中国科学院大学
Medical School
  • 2007-09--2012-07 博士: 中国科学院成都有机化学研究所
  • 2003-09--2007-07 理学学士: 安徽大学
  • 2023.06-至今 - 中科院昆明植物所 - 研究员
  • 2017.03-2023.05 - 中科院昆明植物所 - 副研究员
  • 2013-12-2016-12 - 德国莱布尼茨大学 - 博士后
  • 2013-11-2014-11 - 法国综合理工大学 - 博士后
活性天然产物的全合成及药物化学研究
基于金属或有机小分子催化的不对称合成方法学研究
  • Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A, Chinese Journal of Organic Chemistry, 2024
  • Chiral phosphoric acid catalyzed enantioselective inverse-electron-demand oxa-Diels-Alder reactions to synthesize chiral tricyclic tetrahydropyran derivatives, ORGANIC CHEMISTRY FRONTIERS, 2023
  • Asymmetric Total Synthesis of Antibiotic Elansolid A, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022
  • Enantioselective access to tricyclic tetrahydropyran derivatives by a remote hydrogen bonding mediated intramolecular IEDHDA reaction, NATURE COMMUNICATIONS, 2021
  • An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of Cathepsin L: KGP94, Bioorganic Chemistry, 2021
  • Biomimetic Intramolecular Diels-Alder Reaction to Construct the Tetrahydroindane Core of Elansolid A1/A2, Chinese Journal of Organic Chemistry, 2021
  • Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation, Computational Biology and Chemistry, 2021
  • An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94, BIOORGANIC CHEMISTRY, 2021
  • 基于分子内的仿生Diels-Alder反应构建Elansolid A1/A2的四氢茚烷核心结构, 有机化学, 2021
  • The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
  • Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020
  • Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists, Computational Biology and Chemistry, 2019
  • Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study, Computational Biology and Chemistry, 2019
  • Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer invitro and invivo, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019
  • Homology modeling and 3D-QSAR study of benzhydrylpiperazine delta opioid receptor agonists, COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019
  • Asymmetric Syntheses of Spirooxindole-dihydroquinazolinones by Cyclization Reactions between N-substituted Anthranilamides and Isatins, ADV. SYNTH. CATAL, 2018
  • A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocinconjugates for use in magnet drug targeting, Chem. Eur. J., 2017
  • Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1, CHEMISTRY-A EUROPEAN JOURNAL, 2017
  • Organocatalytic stereocontrolled synthesis of 3,3 '-pyrrolidinyl spirooxindoles by 3+2 annulation of isocyanoesters with methyleneindolinones, CHEMICAL COMMUNICATIONS, 2012
  • A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2011
  • Highly organocatalytic asymmetric michael-ketone aldol-dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles, CHEMICAL COMMUNICATIONS, 2010
天然产物 全合成 药物化学 抗生素 不对称合成 金属催化 有机催化 手性合成 药物候选分子 结构优化

联系我们

欢迎与我们交流!
* Required
* Required
* Required
* Invalid email address
提交此表单,即表示您同意 IoT ONE 可以与您联系并分享洞察和营销信息。
不,谢谢,我不想收到来自 IoT ONE 的任何营销电子邮件。
提交

感谢您的信息!
我们会很快与你取得联系。