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沈坤
Medical School
武汉大学
湖北省
Language: 中文, 英语
有机化学
药物化学
化学生物学
合成
手性
天然产物
药物开发
药物设计
分子机制
不对称合成
Areas of Focus
- 有机化学
- 药物化学
- 化学生物学
- 合成方法学
- 手性药物与天然产物的不对称合成
- 创新药物的研究与开发
- 药物分子作用机制研究
Work Experience
- 2018.9至今 武汉大学药学院，副研究员
- 2013.8 – 2018.7 美国杜克大学化学系，博士后
Academic Background & Achievements
- 2008 – 2013 中国科学院上海有机化学研究所，理学博士
- 2004 – 2008 武汉大学化学与分子科学学院，理学学士
Publications
- Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles, 沈坤; 王强*, 2017
- Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization, 沈坤; Logan, A. W. J.; Colell, J. F. P.; Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.; Malcolmson, S. J.; 王强*, 2017
- Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents, 沈坤; 王强*, 2017
- Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines, Hemric, B. N.; 沈坤; 王强*, 2016
- Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams, 沈坤; 王强*, 2016
- Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines, 沈坤; 王强*, 2015
- Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔*; 胡志, 2017
- Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives, 沈坤; 韩晓; 夏刚; 陆翔*, 2015
- Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source, 沈坤; 韩晓; 陆翔*, 2013
- Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔*, 2012
