Professor | 沈坤 | 数字化转型顾问

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Name	沈坤
Contact Information	kun.shen@whu.edu.cn
Language ability	中文, 英语
Province	湖北省

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Name

沈坤

Contact Information

kun.shen@whu.edu.cn

Language ability

中文, 英语

Province

湖北省

University/Lab Affiliation and Title	武汉大学
Faculty	Medical School
Academic Background & Achievements	2008 – 2013 中国科学院上海有机化学研究所，理学博士 2004 – 2008 武汉大学化学与分子科学学院，理学学士
Work Experience	2018.9至今武汉大学药学院，副研究员 2013.8 – 2018.7 美国杜克大学化学系，博士后

University/Lab Affiliation and Title

武汉大学

Faculty

Medical School

Academic Background & Achievements

2008 – 2013 中国科学院上海有机化学研究所，理学博士
2004 – 2008 武汉大学化学与分子科学学院，理学学士

Work Experience

2018.9至今武汉大学药学院，副研究员
2013.8 – 2018.7 美国杜克大学化学系，博士后

Areas of Focus	有机化学药物化学化学生物学合成方法学手性药物与天然产物的不对称合成创新药物的研究与开发药物分子作用机制研究
Publications	Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles, 沈坤; 王强, 2017 Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization, 沈坤; Logan, A. W. J.; Colell, J. F. P.; Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.; Malcolmson, S. J.; 王强, 2017 Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents, 沈坤; 王强, 2017 Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines, Hemric, B. N.; 沈坤; 王强, 2016 Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams, 沈坤; 王强, 2016 Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines, 沈坤; 王强, 2015 Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔; 胡志, 2017 Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives, 沈坤; 韩晓; 夏刚; 陆翔, 2015 Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source, 沈坤; 韩晓; 陆翔, 2013 Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔, 2012

Areas of Focus

有机化学
药物化学
化学生物学
合成方法学
手性药物与天然产物的不对称合成
创新药物的研究与开发
药物分子作用机制研究

Publications

Copper-Catalyzed Alkene Aminoazidation as a Rapid Entry to 1,2-Diamines and Installation of an Azide Reporter onto Azahetereocycles, 沈坤; 王强*, 2017
Diazirines as Potential Universal Molecular MRI Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization, 沈坤; Logan, A. W. J.; Colell, J. F. P.; Bae, J.; Ortiz, G. X.; Theis, T.; Warren, W. S.; Malcolmson, S. J.; 王强*, 2017
Copper-Catalyzed Aminoalkynylation of Alkenes with Hypervalent Iodine Reagents, 沈坤; 王强*, 2017
Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines, Hemric, B. N.; 沈坤; 王强*, 2016
Copper-catalyzed Aminotrifluoromethylation of Alkenes: A Facile Synthesis of CF3-Containing Lactams, 沈坤; 王强*, 2016
Copper-Catalyzed Diamination of Unactivated Alkenes with Hydroxylamines, 沈坤; 王强*, 2015
Cationic Pd(II)-Catalyzed Arylative Cyclization of 1,6-Enynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔*; 胡志, 2017
Cationic Pd(II)-Catalyzed Cyclization of N-tosyl-aniline Tethered Alkynyl Ketones Initiated by Hydropalladation of Alkynes: A Facile Way to 1,2-Dihydro- or 1,2,3,4-Tetrahydroquinoline Derivatives, 沈坤; 韩晓; 夏刚; 陆翔*, 2015
Cationic Palladium(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source, 沈坤; 韩晓; 陆翔*, 2013
Cationic Palladium(II)-Catalyzed Highly Enantioselective Arylative Cyclization of Alkyne-Tethered Enals or Enones Initiated by Carbopalladation of Alkynes with Arylboronic Acids, 沈坤; 韩晓; 陆翔*, 2012

有机化学药物化学化学生物学合成手性天然产物药物开发药物设计分子机制不对称合成

廖苍松 - 中国科学院大学

Area of Focus
天然产物 | 化学 | 生物学 | 合成 | 酶 | 催化 | 生物催化 | 不对称合成 | 官能团化 | 氨基酸

梁箫 - 中国科学院大学

Area of Focus
天然产物 | 合成 | 化学 | 有机化学 | 不对称合成 | 生物活性化合物 | 药物化学 | 催化 | 全合成 | 生物碱

汪亮亮 - 中国科学院大学

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