Areas of Focus
- Construction and application of genetically modified large animal models
- Development and optimization of new gene editing technologies
Work Experience
- 2022-12 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
- 2018-07 to 2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
- 2018-01 to 2018-06 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher (Probation)
- 2016-07 to 2017-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2011-09 to 2016-07 PhD in Science: University of Chinese Academy of Sciences
- 2007-09 to 2011-07 Bachelor in Engineering: Anhui University
Publications
- Enhancing prime editor flexibility with coiled-coil heterodimers, Kepin Wang, 2024
- Exonuclease editor promotes precision of gene editing in mammalian cells, Kepin Wang, 2024
- Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos, Kepin Wang, 2023
- Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription, Kepin Wang, 2023
- Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Kepin Wang, 2023
- Genome editing pig models with elements for controllable gene expression, Kepin Wang, 2023
- Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, Kepin Wang, 2022
- AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Kepin Wang, 2022
- Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Kepin Wang, 2022
- CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, Kepin Wang, 2021
- Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, Kepin Wang, 2021
- Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses, Kepin Wang, 2020
- ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Kepin Wang, 2020
- Efficient base editing for multiple genes and loci in pigs using base editors, Kepin Wang, 2019
- XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Kepin Wang, 2018
- Engineering crispr/cpf1 with trna promotes genome editing capability in mammalian systems, Kepin Wang, 2018
- Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Kepin Wang, 2017
- Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, Kepin Wang, 2016
Awards
- Outstanding Young Scientist of Guangzhou Branch, Chinese Academy of Sciences (2021-2022): 2023
