Professor | Kepin Wang | Asia Growth Partners

Name	Kepin Wang
Contact Information	wang_kepin@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Kepin Wang

Contact Information

wang_kepin@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2011-09 to 2016-07 PhD in Science: University of Chinese Academy of Sciences 2007-09 to 2011-07 Bachelor in Engineering: Anhui University
Work Experience	2022-12 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2018-07 to 2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher 2018-01 to 2018-06 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher (Probation) 2016-07 to 2017-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher
Awards	Outstanding Young Scientist of Guangzhou Branch, Chinese Academy of Sciences (2021-2022): 2023

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2011-09 to 2016-07 PhD in Science: University of Chinese Academy of Sciences
2007-09 to 2011-07 Bachelor in Engineering: Anhui University

Work Experience

2022-12 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2018-07 to 2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
2018-01 to 2018-06 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher (Probation)
2016-07 to 2017-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher

Awards

Outstanding Young Scientist of Guangzhou Branch, Chinese Academy of Sciences (2021-2022): 2023

Areas of Focus	Construction and application of genetically modified large animal models Development and optimization of new gene editing technologies
Publications	Enhancing prime editor flexibility with coiled-coil heterodimers, Kepin Wang, 2024 Exonuclease editor promotes precision of gene editing in mammalian cells, Kepin Wang, 2024 Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos, Kepin Wang, 2023 Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription, Kepin Wang, 2023 Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Kepin Wang, 2023 Genome editing pig models with elements for controllable gene expression, Kepin Wang, 2023 Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, Kepin Wang, 2022 AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Kepin Wang, 2022 Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Kepin Wang, 2022 CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, Kepin Wang, 2021 Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, Kepin Wang, 2021 Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses, Kepin Wang, 2020 ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Kepin Wang, 2020 Efficient base editing for multiple genes and loci in pigs using base editors, Kepin Wang, 2019 XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Kepin Wang, 2018 Engineering crispr/cpf1 with trna promotes genome editing capability in mammalian systems, Kepin Wang, 2018 Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Kepin Wang, 2017 Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, Kepin Wang, 2016

Areas of Focus

Construction and application of genetically modified large animal models
Development and optimization of new gene editing technologies

Publications

Enhancing prime editor flexibility with coiled-coil heterodimers, Kepin Wang, 2024
Exonuclease editor promotes precision of gene editing in mammalian cells, Kepin Wang, 2024
Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos, Kepin Wang, 2023
Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription, Kepin Wang, 2023
Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Kepin Wang, 2023
Genome editing pig models with elements for controllable gene expression, Kepin Wang, 2023
Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, Kepin Wang, 2022
AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Kepin Wang, 2022
Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Kepin Wang, 2022
CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, Kepin Wang, 2021
Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, Kepin Wang, 2021
Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses, Kepin Wang, 2020
ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, Kepin Wang, 2020
Efficient base editing for multiple genes and loci in pigs using base editors, Kepin Wang, 2019
XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, Kepin Wang, 2018
Engineering crispr/cpf1 with trna promotes genome editing capability in mammalian systems, Kepin Wang, 2018
Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Kepin Wang, 2017
Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, Kepin Wang, 2016

Genetically Modified Large Animal Models Gene Editing Crispr Genome Biotechnology Molecular Biology Genetic Engineering Animal Models Research

Ruilin Tian - Southern University of Science and Technology

Zhang Peng - Wuhan University

Yin Jun - Wuhan University

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