Areas of Focus
- 基因修饰大动物模型构建与应用
- 新型基因编辑技术开发与优化
Work Experience
- 2022-12到现在 - 中国科学院广州生物医药与健康研究院 - 研究员
- 2018-07到2022-12 - 中国科学院广州生物医药与健康研究院 - 副研究员
- 2018-01到2018-06 - 中国科学院广州生物医药与健康研究院 - 副研究员(试聘)
- 2016-07到2017-12 - 中国科学院广州生物医药与健康研究院 - 助理研究员
Academic Background & Achievements
- 2011-09到2016-07 理学博士: 中国科学院大学
- 2007-09到2011-07 工学学士: 安徽大学
Publications
- Enhancing prime editor flexibility with coiled-coil heterodimers, 王可品, 2024
- Exonuclease editor promotes precision of gene editing in mammalian cells, 王可品, 2024
- Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos, 王可品, 2023
- Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription, 王可品, 2023
- Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, 王可品, 2023
- Genome editing pig models with elements for controllable gene expression, 王可品, 2023
- Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus, 王可品, 2022
- AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, 王可品, 2022
- Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, 王可品, 2022
- CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I, 王可品, 2021
- Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants, 王可品, 2021
- Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses, 王可品, 2020
- ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems, 王可品, 2020
- Efficient base editing for multiple genes and loci in pigs using base editors, 王可品, 2019
- XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer, 王可品, 2018
- Engineering crispr/cpf1 with trna promotes genome editing capability in mammalian systems, 王可品, 2018
- Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, 王可品, 2017
- Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering, 王可品, 2016
Awards
- 中国科学院广州分院2021-2022年度优秀青年科技工作者: 2023
