Areas of Focus
- Metabolic Endocrinology Pharmacology
Work Experience
- 2005-04~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Group Leader/Researcher
- 2002-04~2005-03 - National Center for Global Health and Medicine, Japan - Researcher
- 1997-08~2002-03 - Chiba University, Japan - Researcher
- 1992-04~1997-03 - Kobe University, Japan - PhD
Academic Background & Achievements
- 1992-04--1997-03 PhD: Kobe University, Japan
Publications
- Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, 7th Author, 2023
- Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L., 11th Author, 2021
- DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis, 7th Author, 2021
- A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism, 11th Author, 2021
- A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation, 11th Author, 2021
- Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus, 11th Author, 2021
- Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice, 11th Author, 2021
- DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis, 7th Author, 2020
- Cinnamtannin D1 Protects Pancreatic β-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo, 11th Author, 2020
- Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes, 11th Author, 2020
- Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice, 10th Author, 2019
- Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes, 11th Author, 2019
- Corrigendum to 'From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4' Ejmech 154 (2018) 44-59, 12th Author, 2019
- From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 (vol 154, pg 44, 2018), 11th Author, 2019
- Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor, 11th Author, 2019
- Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design, 11th Author, 2018
- Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra, 4th Author, 2018
- Benzbromarone aggravates hepatic steatosis in obese individuals, 11th Author, 2018
- Synergistic anti-hyperglycemia effects of berberine and cinnamtannin D1 in Jiao-tai Pills, 6th Author, 2018
- From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4, 11th Author, 2018
- Benzbromarone aggravates hepatic steatosis in obese individuals, 8th Author, 2018
- Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis, 11th Author, 2018
- Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins, 11th Author, 2018
- 5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma, 11th Author, 2018
- Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression, 11th Author, 2017
- New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum, 4th Author, 2017
- Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf V600E inhibitors, 11th Author, 2017
- Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors, 11th Author, 2017
- Discovery of potent and orally bioavailable gpr40 full agonists bearing thiophen-2-ylpropanoic acid scaffold, 11th Author, 2017
- Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, 11th Author, 2017
- Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER, 5th Author, 2017
- A Novel Sarsolenane Diterpene as a PTP1B Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, 7th Author, 2017
- Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK, 11th Author, 2017
- Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety, 11th Author, 2017
- Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, 3rd Author, 2017
- Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, 11th Author, 2017
- Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, 11th Author, 2017
- Synthesis and Evaluation of Pancreatic Lipase Inhibitory Effects Halogenated Polyunsaturated Lipids from Marine Natural Products: Methyl Xestospongoate and Analogs, 11th Author, 2016
- Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay, 11th Author, 2016
- First Total Synthesis of the Marine Natural Brominated Polyunsaturated Lipid Xestospongenyne as a Potent Pancreatic Lipase Inhibitory Agent, 2nd Author, 2016
- New Alkaloids and alpha-Glucosidase Inhibitory Flavonoids from Ficus hispida, 4th Author, 2016
- Preparation of Methylated Products of A-type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β-Cell, 11th Author, 2016
- Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, 9th Author, 2016
- Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, 11th Author, 2016
- Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H_2O_2-induced apoptosis, 11th Author, 2016
- (2S)-7,4 '-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells, 11th Author, 2015
- Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination., 9th Author, 2015
- Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress, 11th Author, 2015
- New Isoprenylated Phenolic Compounds from Morus laevigata, 6th Author, 2015
- Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells, 11th Author, 2015
- Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, 0th Author, 2015
Awards
- 2014: Research on the chemical components and hypoglycemic active ingredients of oligomeric proanthocyanidins in cinnamon, Third Prize, Municipal Level
