2005-04~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Group Leader/Researcher
2002-04~2005-03 - National Center for Global Health and Medicine, Japan - Researcher
1997-08~2002-03 - Chiba University, Japan - Researcher
1992-04~1997-03 - Kobe University, Japan - PhD
2014: Research on the chemical components and hypoglycemic active ingredients of oligomeric proanthocyanidins in cinnamon, Third Prize, Municipal Level
Research
Metabolic Endocrinology Pharmacology
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation, 7th Author, 2023
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L., 11th Author, 2021
Cinnamtannin D1 Protects Pancreatic β-Cells from Glucolipotoxicity-Induced Apoptosis by Enhancement of Autophagy In Vitro and In Vivo, 11th Author, 2020
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes, 11th Author, 2020
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice, 10th Author, 2019
Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes, 11th Author, 2019
Corrigendum to 'From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4' Ejmech 154 (2018) 44-59, 12th Author, 2019
From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 (vol 154, pg 44, 2018), 11th Author, 2019
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor, 11th Author, 2019
Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design, 11th Author, 2018
Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra, 4th Author, 2018
Benzbromarone aggravates hepatic steatosis in obese individuals, 11th Author, 2018
Synergistic anti-hyperglycemia effects of berberine and cinnamtannin D1 in Jiao-tai Pills, 6th Author, 2018
From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4, 11th Author, 2018
Benzbromarone aggravates hepatic steatosis in obese individuals, 8th Author, 2018
Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis, 11th Author, 2018
Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins, 11th Author, 2018
5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma, 11th Author, 2018
Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression, 11th Author, 2017
New Bicyclic Cembranoids from the South China Sea Soft Coral Sarcophyton trocheliophorum, 4th Author, 2017
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf V600E inhibitors, 11th Author, 2017
Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors, 11th Author, 2017
Discovery of potent and orally bioavailable gpr40 full agonists bearing thiophen-2-ylpropanoic acid scaffold, 11th Author, 2017
Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, 11th Author, 2017
Sarcophytrols G - L, Novel Minor Metabolic Components from South China Sea Soft Coral Sarcophyton trocheliophorum MARENZELLER, 5th Author, 2017
A Novel Sarsolenane Diterpene as a PTP1B Inhibitor from Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller, 7th Author, 2017
Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK, 11th Author, 2017
Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety, 11th Author, 2017
Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, 3rd Author, 2017
Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression, 11th Author, 2017
Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria, 11th Author, 2017
Synthesis and Evaluation of Pancreatic Lipase Inhibitory Effects Halogenated Polyunsaturated Lipids from Marine Natural Products: Methyl Xestospongoate and Analogs, 11th Author, 2016
Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay, 11th Author, 2016
First Total Synthesis of the Marine Natural Brominated Polyunsaturated Lipid Xestospongenyne as a Potent Pancreatic Lipase Inhibitory Agent, 2nd Author, 2016
New Alkaloids and alpha-Glucosidase Inhibitory Flavonoids from Ficus hispida, 4th Author, 2016
Preparation of Methylated Products of A-type Procyanidin Trimers in Cinnamon Bark and Their Protective Effects on Pancreatic β-Cell, 11th Author, 2016
Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, 9th Author, 2016
Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, 11th Author, 2016
Chlorogenic acid analogues from Gynura nepalensis protect H9c2 cardiomyoblasts against H_2O_2-induced apoptosis, 11th Author, 2016
(2S)-7,4 '-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells, 11th Author, 2015
Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination., 9th Author, 2015
Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress, 11th Author, 2015
New Isoprenylated Phenolic Compounds from Morus laevigata, 6th Author, 2015
Inhibitory Effects of (2 ' R)-2 ',3 '-dihydro-2 '-(1-hydroxy-1-methylethyl)-2,6 '-bibenzofuran-6,4 '-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells, 11th Author, 2015
Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, 0th Author, 2015
