Professor | Shi Yin | Asia Growth Partners

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Name	Shi Yin
Contact Information	yinshi@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Shi Yin

Contact Information

yinshi@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2006.9–2010.6 Bachelor's Degree: Zhejiang University, Department of Biological Sciences 2010.8–2015.4 PhD: National University of Singapore, Supervisor: Prof. Shen Hanming Shi Yin has long been engaged in the study of the mechanisms and functions of autophagy and related stress metabolism in cancer treatment.
Work Experience	2015.5-2017.5 - National University of Singapore - Postdoctoral Researcher 2017.6-2022.12 - Zhejiang University - Lecturer 2023.1-Present - Zhejiang University - Associate Professor

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2006.9–2010.6 Bachelor's Degree: Zhejiang University, Department of Biological Sciences
2010.8–2015.4 PhD: National University of Singapore, Supervisor: Prof. Shen Hanming
Shi Yin has long been engaged in the study of the mechanisms and functions of autophagy and related stress metabolism in cancer treatment.

Work Experience

2015.5-2017.5 - National University of Singapore - Postdoctoral Researcher
2017.6-2022.12 - Zhejiang University - Lecturer
2023.1-Present - Zhejiang University - Associate Professor

Areas of Focus	Tumor Metabolism and Immunoregulation
Publications	PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity, Ye, Z.; Ng, C.P.; Liu, H.; Bao, Q.; Xu, S.; Zu, D.; He, Y.; Huang, Y.; Al-Aidaroos A.Q.; Guo, K.; Li, J.; Yaw, L.P.; Xiong, Q.; Thura, M.; Zheng, W.; Guan, F.; Cheng, X.; Shi, Y.; Zeng, Q., 2024 PRL-3 dephosphorylates p38 MAPK to promote cell survival under stress, Shi, Y.; Xu, S.; Ngoi, N.Y.L.; Hui, Y.; Zeng Q.; Ye, Z., 2021 Cholesterol-enriched membrane micro-domains deficiency induces doxorubicin resistance via promoting autophagy in breast cancer, Shi, Y.; Ye, Z.; Guang, L.; Yang, N.; Zhang, J.; Wang, L.; Cui, J.; del Pozo, M.A.; Wu, Y.; Xia, D.; Shen, H.M., 2021 Mechanistic investigation of the specific anticancer property of artemisinin and its combination with aminolevulinic acid for enhanced anticolorectal cancer activity, Wang, J.; Zhang, J.; Shi, Y.; Xu, C.; Zhang, C.; Wong, Y.K.; Lee, Y.M.; Krishna, S.; He, Y.; Lim, T.K.; Sim, W.; Hua, Z.C.; Shen, H.M.; Lin, Q., 2017 Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy, Shi, Y.; Tan, S.H.; Ng, S.; Zhou, J.; Yang, N.; Koo, G.B.; McMahon, K.A.; Parton, R.G.; Hill, M.M.; del Pozo, M.A.; Kim, Y.S.; Shen, H.M., 2015 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy, Ye, Z.; Shi, Y.; Lees-Miller, S.P.; Tainer, J.A., 2021 Epigenetic regulation of autophagy beyond the cytoplasm: a review, Shi, Y.; Shen, H.M.; Gopalakrishnan, V.; Gordon, N., 2021 Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression, Shi, Y.; Xu, S.; Ngoi, N.Y.L.; Hui, Y.; Ye, Z., 2021 Autophagy in health and disease: From molecular mechanisms to therapeutic target, Lu, G.; Wang, Y.; Shi, Y.; Zhang, Z.; Huang, C.; He, W.; Wang, C.; Shen, H.M., 2022 Acetylation of STX17 (syntaxin 17) controls autophagosome maturation, Shen, Q.; Shi, Y.; Liu, J.; Su, H.; Huang, J.; Zhang, Y.; Peng, C.; Zhou, T.; Sun, Q.; Wan, W.; Liu, W., 2021 mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux, Wan, W.; You, Z.; Zhou, L.; Xu, Y.; Peng, C.; Zhou, T.; Yi, C.; Shi, Y.; Liu, W., 2018 TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction, You, Z.; Xu, Y.; Wan, W.; Zhou, L.; Li, J.; Zhou, T.; Shi, Y.; Liu, W., 2019 PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy, Wang, L.; Cho, Y.L.; Tang, Y.; Wang, J.; Park, J.E.; Wu, Y.; Wang, C.; Tong, Y.; Chawla, R.; Zhang, J.; Shi, Y.; Deng, S.; Lu, G.; Wu, Y.; Tan, H.W.S.; Pawijit, P.; Lim, G.G.Y.; Chan, H.Y.; Zhang, J.; Fang, L.; Yu, H.; Liou, Y.C.; Karthik, M.; Bay, B.H.; Lim, K.L.; Sze, S.K.; Yap, C.T.; Shen, H.M., 2018 Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation, Lu, G.; Yi, J.; Gubas, A.; Wang, Y.T.; Wu, Y.; Ren, Y.; Wu, M.; Shi, Y.; Ouyang, C.; Tan, H.W.S.; Wang, T.; Wang, L.; Yang, N.; Deng, S.; Xia, D.; Chen, R.H.; Tooze, S.A.; Shen, H.M., 2019 GRB2 enforces homology-directed repair initiation by MRE11, Ye, Z.; Xu, S.; Shi, Y.; Bacolla, A.; Syed, A.; Moiani, D.; Tsai, C.L.; Shen, Q.; Peng, G.; Leonard, P.G.; Jones, D. E.; Wang, B.; Tainer, J. A.; Ahmed, Z., 2021 Nonradioactive quantification of autophagic protein degradation with (L)-azidohomoalanine labeling, Wang, J.; Zhang, J.; Lee, Y.M.; Ng, S.; Shi, Y.; Hua, Z.C.; Lin, Q.; Shen, H.M., 2017 Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway, Tan, S.H.; Shui, G.; Zhou, J.; Shi, Y.; Huang, J.; Xia, D.; Wenk, M.R.; Shen, H.M., 2013 Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin, Yang, N.; Tan, S.H.; Ng S.; Shi, Y.; Zhou, J.; Shyong, K.; Tan, W.; Wong, W.S.F.; Shen, H.M., 2014 CRISPR system for genome engineering: the application for autophagy study, Cui, J.; Chew, S.J.L.; Shi, Y.; Gong, Z.; Shen, H.M., 2017

Areas of Focus

Tumor Metabolism and Immunoregulation

Publications

PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity, Ye, Z.; Ng, C.P.; Liu, H.; Bao, Q.; Xu, S.; Zu, D.; He, Y.; Huang, Y.; Al-Aidaroos A.Q.; Guo, K.; Li, J.; Yaw, L.P.; Xiong, Q.; Thura, M.; Zheng, W.; Guan, F.; Cheng, X.; Shi, Y.; Zeng, Q., 2024
PRL-3 dephosphorylates p38 MAPK to promote cell survival under stress, Shi, Y.; Xu, S.; Ngoi, N.Y.L.; Hui, Y.; Zeng Q.; Ye, Z., 2021
Cholesterol-enriched membrane micro-domains deficiency induces doxorubicin resistance via promoting autophagy in breast cancer, Shi, Y.; Ye, Z.; Guang, L.; Yang, N.; Zhang, J.; Wang, L.; Cui, J.; del Pozo, M.A.; Wu, Y.; Xia, D.; Shen, H.M., 2021
Mechanistic investigation of the specific anticancer property of artemisinin and its combination with aminolevulinic acid for enhanced anticolorectal cancer activity, Wang, J.; Zhang, J.; Shi, Y.; Xu, C.; Zhang, C.; Wong, Y.K.; Lee, Y.M.; Krishna, S.; He, Y.; Lim, T.K.; Sim, W.; Hua, Z.C.; Shen, H.M.; Lin, Q., 2017
Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy, Shi, Y.; Tan, S.H.; Ng, S.; Zhou, J.; Yang, N.; Koo, G.B.; McMahon, K.A.; Parton, R.G.; Hill, M.M.; del Pozo, M.A.; Kim, Y.S.; Shen, H.M., 2015
Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy, Ye, Z.; Shi, Y.; Lees-Miller, S.P.; Tainer, J.A., 2021
Epigenetic regulation of autophagy beyond the cytoplasm: a review, Shi, Y.; Shen, H.M.; Gopalakrishnan, V.; Gordon, N., 2021
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression, Shi, Y.; Xu, S.; Ngoi, N.Y.L.; Hui, Y.; Ye, Z., 2021
Autophagy in health and disease: From molecular mechanisms to therapeutic target, Lu, G.; Wang, Y.; Shi, Y.; Zhang, Z.; Huang, C.; He, W.; Wang, C.; Shen, H.M., 2022
Acetylation of STX17 (syntaxin 17) controls autophagosome maturation, Shen, Q.; Shi, Y.; Liu, J.; Su, H.; Huang, J.; Zhang, Y.; Peng, C.; Zhou, T.; Sun, Q.; Wan, W.; Liu, W., 2021
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux, Wan, W.; You, Z.; Zhou, L.; Xu, Y.; Peng, C.; Zhou, T.; Yi, C.; Shi, Y.; Liu, W., 2018
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction, You, Z.; Xu, Y.; Wan, W.; Zhou, L.; Li, J.; Zhou, T.; Shi, Y.; Liu, W., 2019
PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy, Wang, L.; Cho, Y.L.; Tang, Y.; Wang, J.; Park, J.E.; Wu, Y.; Wang, C.; Tong, Y.; Chawla, R.; Zhang, J.; Shi, Y.; Deng, S.; Lu, G.; Wu, Y.; Tan, H.W.S.; Pawijit, P.; Lim, G.G.Y.; Chan, H.Y.; Zhang, J.; Fang, L.; Yu, H.; Liou, Y.C.; Karthik, M.; Bay, B.H.; Lim, K.L.; Sze, S.K.; Yap, C.T.; Shen, H.M., 2018
Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation, Lu, G.; Yi, J.; Gubas, A.; Wang, Y.T.; Wu, Y.; Ren, Y.; Wu, M.; Shi, Y.; Ouyang, C.; Tan, H.W.S.; Wang, T.; Wang, L.; Yang, N.; Deng, S.; Xia, D.; Chen, R.H.; Tooze, S.A.; Shen, H.M., 2019
GRB2 enforces homology-directed repair initiation by MRE11, Ye, Z.; Xu, S.; Shi, Y.; Bacolla, A.; Syed, A.; Moiani, D.; Tsai, C.L.; Shen, Q.; Peng, G.; Leonard, P.G.; Jones, D. E.; Wang, B.; Tainer, J. A.; Ahmed, Z., 2021
Nonradioactive quantification of autophagic protein degradation with (L)-azidohomoalanine labeling, Wang, J.; Zhang, J.; Lee, Y.M.; Ng, S.; Shi, Y.; Hua, Z.C.; Lin, Q.; Shen, H.M., 2017
Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway, Tan, S.H.; Shui, G.; Zhou, J.; Shi, Y.; Huang, J.; Xia, D.; Wenk, M.R.; Shen, H.M., 2013
Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin, Yang, N.; Tan, S.H.; Ng S.; Shi, Y.; Zhou, J.; Shyong, K.; Tan, W.; Wong, W.S.F.; Shen, H.M., 2014
CRISPR system for genome engineering: the application for autophagy study, Cui, J.; Chew, S.J.L.; Shi, Y.; Gong, Z.; Shen, H.M., 2017

Tumor Metabolism Immunoregulation Cancer Cells Survival Mechanisms Death Mechanisms Immune Effects Metabolic Environment Autophagy Signal Pathways

Jinbiao Zhan - Zhejiang University

Wei Chen - Zhejiang University

Xuefei Zhou - Zhejiang University

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