Professor | Fei Wang | Asia Growth Partners

Name	Fei Wang
Contact Information	wangfei@cib.ac.cn
Language ability	Chinese, English
Province	Sichuan

Name

Fei Wang

Contact Information

wangfei@cib.ac.cn

Language ability

Chinese, English

Province

Sichuan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2000-09--2005-09 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences 1996-09--2000-07 Bachelor's: Henan Normal University
Work Experience	2014-01~Present - Chinese Academy of Sciences Chengdu Institute of Biology - Researcher 2008-03~2013-12 - Chinese Academy of Sciences Chengdu Institute of Biology - Associate Researcher 2005-10~2008-02 - University of California San Francisco - Postdoctoral
Awards	Chinese Academy of Sciences President's Special Award (2004): Special Prize Chinese Academy of Sciences Di'ao Award (2004): First Prize Graduate Student Excellent Thesis Award (2004): First Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2000-09--2005-09 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
1996-09--2000-07 Bachelor's: Henan Normal University

Work Experience

2014-01~Present - Chinese Academy of Sciences Chengdu Institute of Biology - Researcher
2008-03~2013-12 - Chinese Academy of Sciences Chengdu Institute of Biology - Associate Researcher
2005-10~2008-02 - University of California San Francisco - Postdoctoral

Awards

Chinese Academy of Sciences President's Special Award (2004): Special Prize
Chinese Academy of Sciences Di'ao Award (2004): First Prize
Graduate Student Excellent Thesis Award (2004): First Prize

Areas of Focus	Chemical biology research on interferon, estrogen biosynthesis, and microRNA pathways
Publications	Separation and identification of terpene-conjugated curcuminoids based on liquid chromatography-tandem mass spectrometry and their in vitro anti-inflammatory activities, Liao, Yangyang, Zhang, Xinjie, Cao, Dongyi, Wang, Fei, Chen, Hulan, Li, Rui, 2023 Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming, Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang, 2022 Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP- Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Peng, Ting, He, Yujiao, Wang, Tao, Yu, Jialing, Ma, Xiaofang, Zhou, Zongyuan, Sheng, Yuwen, Li, Lingyu, Peng, Huipan, Li, Sheng, Zou, Jiawei, Yuan, Yi, Zhao, Yongyun, Shi, Hailong, Li, Fu, Liu, Wanli, Hu, Kaifeng, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, 2022 Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa, Zhang, Xuejian, Cao, Yu, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2022 Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy, Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo, 2022 半胱氨酸天冬氨酸蛋白水解酶caspase-1抑制剂体外筛选模型的构建及应用, 李润择, 曹东怡, 张中辉, 李晟, 吴嘉思, 王飞, 2022 A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation, Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang, 2022 Sennoside A is a novel inhibitor targeting caspase-1, Wu, Jiasi, Lan, Yuejia, Shi, Xiaoke, Huang, Wenge, Li, Sheng, Zhang, Jizhou, Wang, Huan, Wang, Fei, Meng, Xianli, 2022 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡, 席芮颖, 付乃洁, 李润择, 张国林, 王飞, 2022 Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo, Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang, 2022 Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways, Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang, 2022 (+/-)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa, Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2021 New 2-isobutylmalates from the tubers of Bletilla striata and their potential anti-pulmonary fibrosis activities, Xiao-Yu Hou, Yu Cao, Bing-Lan Wu, Bin Chen, Fu Li, Fei Wang, Ming-Kui Wang, Lun Wang, 2021 A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating beta-TrCP E3 Ubiquitin Ligase, Peng, Ting, Wonganan, Orawan, Zhang, Zhonghui, Yu, Jialing, Xi, Ruiying, Cao, Yu, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei, 2021 Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma, Zhou, Zongyuan, Li, Yiming, Ma, Xiaofang, Cao, Biyun, Peng, Ting, Sheng, Yuwen, Peng, Huipan, Li, Runze, Cao, Yu, Xi, Ruiying, Li, Fu, Wang, Mengru, Sun, Handong, Zhang, Guolin, Zhang, Hongbin, Hu, Kaifeng, Xiao, Weilie, Wang, Fei, 2021 氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡, 席芮颖, 付乃洁, 李润择, 张国林, 王飞, 2021 A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf, Laura, Gertrude Foudjo Melacheu, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Seguin, Elisabeth, Wandji, Jean, 2021 Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway, Wisanwattana, Wisanee, Wongkrajang, Kanjana, Cao, Dongyi, Shi, Xiaoke, Zhang, Zhonghui, Zhou, Zongyuan, Li, Fu, Mei, Qinggang, Wang, Chun, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei, 2021 Enantioselective 4+2 Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids, Xu, Jian, Li, Runze, Xu, Nian, Liu, Xiaohua, Wang, Fei, Feng, Xiaoming, 2021 A novel ferrocene-palladium metal complex: synthesis, single crystal structure, in vitro cytotoxicity study and molecular docking, Zhang, Zhonghui, Du, Guoyuan, Gong, Guidong, Sheng, Yuwen, Lu, Xiangyu, Cai, Wentao, Wang, Fei, Zhao, Gang, 2021 Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway ofMelia toosendan, Lian, Xufan, Zhang, Xiuli, Wang, Fei, Wang, Xiaoning, Xue, Zheyong, Qi, Xiaoquan, 2020 Viburnumfocesides A - D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides, Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2020 Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone, Xiong, Wei, Wang, Xiaohong, Shen, Xianyan, Hu, Cuifang, Wang, Xin, Wang, Fei, Zhang, Guolin, Wang, Chun, 2020 Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity, Zhang, PuZhao, Zhang, YaMei, Lin, Yuan, Wang, Fei, Zhang, GuoLin, 2020 Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways, Fei Wang, 2020 Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), Du, BaoWen, Zhang, XingJie, Shi, Nan, Peng, Ting, Gao, JunBo, Azimova, Bahtigul, Zhang, Ruihan, Pu, DeBing, Wang, Chun, Abduvaliev, Anvar, Rakhmanov, Alisher, Zhang, GuoLin, Xiao, WeiLie, Wang, Fei, 2020 Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa, Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 0202

Areas of Focus

Chemical biology research on interferon, estrogen biosynthesis, and microRNA pathways

Publications

Separation and identification of terpene-conjugated curcuminoids based on liquid chromatography-tandem mass spectrometry and their in vitro anti-inflammatory activities, Liao, Yangyang, Zhang, Xinjie, Cao, Dongyi, Wang, Fei, Chen, Hulan, Li, Rui, 2023
Identification of pyruvate carboxylase as the cellular target of natural bibenzyls with potent anticancer activity against hepatocellular carcinoma via metabolic reprogramming, Yuwen Sheng, Yuwen Chen, Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang, Wei Jiao, Fei Wang, 2022
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP- Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Peng, Ting, He, Yujiao, Wang, Tao, Yu, Jialing, Ma, Xiaofang, Zhou, Zongyuan, Sheng, Yuwen, Li, Lingyu, Peng, Huipan, Li, Sheng, Zou, Jiawei, Yuan, Yi, Zhao, Yongyun, Shi, Hailong, Li, Fu, Liu, Wanli, Hu, Kaifeng, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, 2022
Antifibrotic pyridine-containing monoterpene alkaloids from Caryopteris glutinosa, Zhang, Xuejian, Cao, Yu, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2022
Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy, Guidong Gong, Jiezhou Pan, Yunxiang He, Jiaojiao Shang, Xiaoling Wang, Yaoyao Zhang, Guolin Zhang, Fei Wang, Gang Zhao, Junling Guo, 2022
半胱氨酸天冬氨酸蛋白水解酶caspase-1抑制剂体外筛选模型的构建及应用, 李润择, 曹东怡, 张中辉, 李晟, 吴嘉思, 王飞, 2022
A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation, Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang, 2022
Sennoside A is a novel inhibitor targeting caspase-1, Wu, Jiasi, Lan, Yuejia, Shi, Xiaoke, Huang, Wenge, Li, Sheng, Zhang, Jizhou, Wang, Huan, Wang, Fei, Meng, Xianli, 2022
氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡, 席芮颖, 付乃洁, 李润择, 张国林, 王飞, 2022
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo, Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang, 2022
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways, Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang, 2022
(+/-)-Caryopterisines A and B, dimeric monoterpene alkaloids with unprecedented 6/5/5/5/6 pentacyclic rings scaffold from Caryopteris glutinosa, Zhang, Xuejian, Luo, Guoyong, Cao, Yu, Mishig, Dumaa, Lodonjav, Munkhgerel, Pan, Dabo, Yao, Xiaojun, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2021
New 2-isobutylmalates from the tubers of Bletilla striata and their potential anti-pulmonary fibrosis activities, Xiao-Yu Hou, Yu Cao, Bing-Lan Wu, Bin Chen, Fu Li, Fei Wang, Ming-Kui Wang, Lun Wang, 2021
A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating beta-TrCP E3 Ubiquitin Ligase, Peng, Ting, Wonganan, Orawan, Zhang, Zhonghui, Yu, Jialing, Xi, Ruiying, Cao, Yu, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei, 2021
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma, Zhou, Zongyuan, Li, Yiming, Ma, Xiaofang, Cao, Biyun, Peng, Ting, Sheng, Yuwen, Peng, Huipan, Li, Runze, Cao, Yu, Xi, Ruiying, Li, Fu, Wang, Mengru, Sun, Handong, Zhang, Guolin, Zhang, Hongbin, Hu, Kaifeng, Xiao, Weilie, Wang, Fei, 2021
氯氰碘柳胺钠通过抑制蛋白酪氨酸磷酸酶SHP2诱导RAS突变型肺癌细胞衰老和死亡, 席芮颖, 付乃洁, 李润择, 张国林, 王飞, 2021
A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf, Laura, Gertrude Foudjo Melacheu, Njoya, Emmanuel Mfotie, Jouda, JeanBosco, Kweka, Brussine Nadege Wakeu, Mbazoa, Celine Djama, Wang, Fei, Seguin, Elisabeth, Wandji, Jean, 2021
Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway, Wisanwattana, Wisanee, Wongkrajang, Kanjana, Cao, Dongyi, Shi, Xiaoke, Zhang, Zhonghui, Zhou, Zongyuan, Li, Fu, Mei, Qinggang, Wang, Chun, Suksamrarn, Apichart, Zhang, Guolin, Wang, Fei, 2021
Enantioselective 4+2 Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids, Xu, Jian, Li, Runze, Xu, Nian, Liu, Xiaohua, Wang, Fei, Feng, Xiaoming, 2021
A novel ferrocene-palladium metal complex: synthesis, single crystal structure, in vitro cytotoxicity study and molecular docking, Zhang, Zhonghui, Du, Guoyuan, Gong, Guidong, Sheng, Yuwen, Lu, Xiangyu, Cai, Wentao, Wang, Fei, Zhao, Gang, 2021
Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway ofMelia toosendan, Lian, Xufan, Zhang, Xiuli, Wang, Fei, Wang, Xiaoning, Xue, Zheyong, Qi, Xiaoquan, 2020
Viburnumfocesides A - D, 1-O-isovaleroylated iridoid 11-O-alloside derivatives from Viburnum foetidum var. ceanothoides, Wang, Dongmei, Yang, Yun, Shi, Xiaoke, Yang, Kaitai, Yin, Kaipu, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 2020
Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone, Xiong, Wei, Wang, Xiaohong, Shen, Xianyan, Hu, Cuifang, Wang, Xin, Wang, Fei, Zhang, Guolin, Wang, Chun, 2020
Three new diterpenes from Dysoxylum lukii and their NO production inhibitory activity, Zhang, PuZhao, Zhang, YaMei, Lin, Yuan, Wang, Fei, Zhang, GuoLin, 2020
Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp.CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways, Fei Wang, 2020
Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), Du, BaoWen, Zhang, XingJie, Shi, Nan, Peng, Ting, Gao, JunBo, Azimova, Bahtigul, Zhang, Ruihan, Pu, DeBing, Wang, Chun, Abduvaliev, Anvar, Rakhmanov, Alisher, Zhang, GuoLin, Xiao, WeiLie, Wang, Fei, 2020
Diterpenoids caryopterisoids D - Q and iridoid glucoside derivatives caryopterisides F - H from Caryopteris glutinosa, Zhang, Xuejian, Peng, Ting, Shi, Xiaoke, Fang, Dongmei, Tang, Lin, Chen, Fang, Wang, Fei, Zhang, Guolin, Luo, Yinggang, 0202

Interferon Estrogen Biosynthesis Microrna Chemical Biology Signal Pathways Natural Products Drug Discovery Mechanism Of Action Cell Receptors

Li Lu - Wuhan University

Yuhui Sun - Wuhan University

Yi Yu - Wuhan University

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