Professor | Xie Zuoqian | Asia Growth Partners

Name	Xie Zuoqian
Contact Information	zqxie@simm.ac.cn
Language ability	English, Chinese
Province	Shanghai

Name

Xie Zuoqian

Contact Information

zqxie@simm.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2014-09 to 2016-04 Visiting Scholar: Yale University 2004-09 to 2018-06 PhD in Biochemistry and Molecular Biology: Shanghai Jiao Tong University 1999-09 to 2004-07 Bachelor's in Clinical Medicine: Wenzhou Medical University
Work Experience	2016-11 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Master's Supervisor 2016-04 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher 2014-09 to 2016-04 - Yale University - Visiting Scholar 2012-09 to 2014-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher 2011-12 to 2012-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher 2009-07 to 2011-11 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher 2004-09 to 2018-06 - Shanghai Jiao Tong University - PhD in Biochemistry and Molecular Biology 1999-09 to 2004-07 - Wenzhou Medical University - Bachelor's in Clinical Medicine

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2014-09 to 2016-04 Visiting Scholar: Yale University
2004-09 to 2018-06 PhD in Biochemistry and Molecular Biology: Shanghai Jiao Tong University
1999-09 to 2004-07 Bachelor's in Clinical Medicine: Wenzhou Medical University

Work Experience

2016-11 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Master's Supervisor
2016-04 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2014-09 to 2016-04 - Yale University - Visiting Scholar
2012-09 to 2014-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2011-12 to 2012-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
2009-07 to 2011-11 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
2004-09 to 2018-06 - Shanghai Jiao Tong University - PhD in Biochemistry and Molecular Biology
1999-09 to 2004-07 - Wenzhou Medical University - Bachelor's in Clinical Medicine

Areas of Focus	Tumor Pharmacology
Publications	Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder, First Author, 2024 Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth, Not mentioned, 2023 Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway, Not mentioned, 2023 Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists, Not mentioned, 2022 Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation, Not mentioned, 2022 Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, First Author, 2022 Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis, Not mentioned, 2022 Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration, Not mentioned, 2022 HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities, Not mentioned, 2022 Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer, Not mentioned, 2022 Genomic Heterogeneity and the Small Renal Mass, Second Author, 2018 Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration, Eleventh Author, 2017 Development of the First Generation of Disulfide-Based Subtype Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors, Second Author, 2017 Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity, Not mentioned, 2017 Phosphoglycerate mutase 1 (PGAM1) regulates dNTP pool and promotes homologous recombination repair in cancer cells., Not mentioned, 2017 Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma., Fifth Author, 2016 MET Inhibition in Clear Cell Renal Cell Carcinoma, First Author, 2016 Lactate Dehydrogenase B Is Associated with the Response to Neoadjuvant Chemotherapy in Oral Squamous Cell Carcinoma, Eleventh Author, 2015 JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification, Second Author, 2015

Areas of Focus

Tumor Pharmacology

Publications

Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder, First Author, 2024
Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth, Not mentioned, 2023
Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway, Not mentioned, 2023
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists, Not mentioned, 2022
Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation, Not mentioned, 2022
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, First Author, 2022
Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis, Not mentioned, 2022
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration, Not mentioned, 2022
HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities, Not mentioned, 2022
Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer, Not mentioned, 2022
Genomic Heterogeneity and the Small Renal Mass, Second Author, 2018
Phosphoglycerate Mutase 1 Predicts the Poor Prognosis of Oral Squamous Cell Carcinoma and is Associated with Cell Migration, Eleventh Author, 2017
Development of the First Generation of Disulfide-Based Subtype Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors, Second Author, 2017
Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity, Not mentioned, 2017
Phosphoglycerate mutase 1 (PGAM1) regulates dNTP pool and promotes homologous recombination repair in cancer cells., Not mentioned, 2017
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma., Fifth Author, 2016
MET Inhibition in Clear Cell Renal Cell Carcinoma, First Author, 2016
Lactate Dehydrogenase B Is Associated with the Response to Neoadjuvant Chemotherapy in Oral Squamous Cell Carcinoma, Eleventh Author, 2015
JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification, Second Author, 2015

Tumor Pharmacology Cancer Drug Development Immunotherapy Biochemistry Molecular Biology Sting Pathway Antitumor Clinical Research

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Xin Liu - Wuhan University

Bin Guo - University of Chinese Academy of Sciences

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