1987-09--1992-10 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1982-09--1987-07 Bachelor: Department of Chemistry, East China Normal University
2021-03~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Party Secretary and Deputy Director
2018-09~2021-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Deputy Party Secretary and Secretary of the Discipline Inspection Commission
2009-02~2021-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Deputy Director
2002-02~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher and Doctoral Supervisor
1997-10~1998-09 - Bayer Central Research Institute, Leverkusen, Germany - Visiting Scientist
1995-12~2002-01 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
1994-01~1995-11 - Institute of Organic Chemistry, University of Munich, Germany - Postdoctoral Researcher
1992-10~1995-11 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
1987-09~1992-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD Student
1982-09~1987-07 - Department of Chemistry, East China Normal University - Bachelor Student
2020 Shanghai Leading Talent: City Level, 2020
Zhu Li Yuehua Excellent Teacher Award: Institute Level, 2009
National Natural Science Foundation Outstanding Youth Fund: National Level, 2009
Chinese Academy of Sciences - Bayer Young Scientist Award: Institute Level, 2008
Shanghai Pharmaceutical Science and Technology Second Prize: Provincial Level, 2007
Research
Natural Product Chemistry Traditional Chinese Medicine
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment, 11th Author, 2023
Application of native mass spectrometry in natural product research, 4th Author, 2022
Cytotoxic guaianolides and seco-guaianolides from Artemisia atrovirens, 11th Author, 2021
Dimeric 9,10-dihydrophenanthrene derivatives from Bletilla striata and their atropisomeric nature, 11th Author, 2021
Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources, 15th Author, 2021
Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans, 7th Author, 2021
Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities, 5th Author, 2021
Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors, 6th Author, 2021
Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging, 11th Author, 2020
Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes, 6th Author, 2020
Trigonostemons G and H, dinorditerpenoid dimers with axially chiral biaryl linkage from Trigonostemon chinensis, 11th Author, 2020
Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy, 11th Author, 2020
Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway, 11th Author, 2020
Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, 11th Author, 2020
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, 11th Author, 2020
Targeted isolation of two disesquiterpenoid macrocephadiolides A and B from Ainsliaea macrocephala using a molecular networking-based dereplication strategy, 11th Author, 2020
Tricarabrols A-C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi, 11th Author, 2020
Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain, 5th Author, 2020
Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy, 11th Author, 2020
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening, 11th Author, 2020
Identification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine, 11th Author, 2019
Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration, 6th Author, 2019
A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation, 6th Author, 2019
Intestinal and hepatic biotransformation of pyrrolizidine alkaloid N-oxides to toxic pyrrolizidine alkaloids, 4th Author, 2019
Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis, 11th Author, 2019
Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica, 11th Author, 2019
Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure, 7th Author, 2019
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, 3rd Author, 2019
Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi, 11th Author, 2019
Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, 11th Author, 2019
Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules, 3rd Author, 2019
Natural constituents from food sources: potential therapeutic agents against muscle wasting, 4th Author, 2019
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer, 11th Author, 2019
Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules, 3rd Author, 2019
Phosphocreatine attenuates Gynura segetum -induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway, 7th Author, 2019
Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities, 11th Author, 2019
Immune modulation of a lipid-soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor-burdened mouse model
