Professor | Yang Weibo | Asia Growth Partners

Name	Yang Weibo
Contact Information	yweibo@simm.ac.cn
Language ability	Chinese, German, English
Province	Shanghai

Name

Yang Weibo

Contact Information

yweibo@simm.ac.cn

Language ability

Chinese, German, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2010-09 to 2013-08 PhD: Heidelberg University 2007-08 to 2010-07 Master's: Dalian University of Technology 2003-09 to 2007-07 Bachelor's: Liaoning University of Science and Technology
Work Experience	2013-12 to 2016-10 - The Scripps Research Institute - Research Assistant 2013-08 to 2013-10 - Heidelberg University - Research Assistant 2010-09 to 2013-08 - Heidelberg University - PhD 2007-08 to 2010-07 - Dalian University of Technology - Master's 2003-09 to 2007-07 - Liaoning University of Science and Technology - Bachelor's
Awards	2023: Leading Goose Award, University of Chinese Academy of Sciences 2023: 18th West Lake Talent Program 2023: Outstanding Party Worker, Shanghai Institute of Materia Medica 2023: Outstanding Academic Leader, Shanghai 2023: Pearl Elite Talent, Pudong New Area 2023: Leading Project of the Oriental Talent Program (16th batch of Shanghai Leading Talents) 2019: Shanghai Youth Science and Technology Star 2018: Outstanding Mentor, Chinese Academy of Sciences 2017: Shanghai Youth Top Talent 2016: Thieme Chemistry Journals Award

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2010-09 to 2013-08 PhD: Heidelberg University
2007-08 to 2010-07 Master's: Dalian University of Technology
2003-09 to 2007-07 Bachelor's: Liaoning University of Science and Technology

Work Experience

2013-12 to 2016-10 - The Scripps Research Institute - Research Assistant
2013-08 to 2013-10 - Heidelberg University - Research Assistant
2010-09 to 2013-08 - Heidelberg University - PhD
2007-08 to 2010-07 - Dalian University of Technology - Master's
2003-09 to 2007-07 - Liaoning University of Science and Technology - Bachelor's

Awards

2023: Leading Goose Award, University of Chinese Academy of Sciences
2023: 18th West Lake Talent Program
2023: Outstanding Party Worker, Shanghai Institute of Materia Medica
2023: Outstanding Academic Leader, Shanghai
2023: Pearl Elite Talent, Pudong New Area
2023: Leading Project of the Oriental Talent Program (16th batch of Shanghai Leading Talents)
2019: Shanghai Youth Science and Technology Star
2018: Outstanding Mentor, Chinese Academy of Sciences
2017: Shanghai Youth Top Talent
2016: Thieme Chemistry Journals Award

Areas of Focus	Organometallic Chemistry Medicinal Chemistry
Publications	Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance, Yang Weibo, 2023 Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C-H activation: Macrocyclic oxime inhibitor of influenza H1N1, Yang Weibo, 2023 Rhodium(III)-Catalyzed C-H/O-2 Dual Activation and Macrocyclization: Synthesis and Evaluation of Pyrido2,1-aisoindole Grafted Macrocyclic Inhibitors for Influenza H1N1, Yang Weibo, 2023 A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis, Yang Weibo, 2022 Natural scaffolds-inspired synthesis of CF_(3)-substituted macrolides enabled by Rh-catalyzed C–H alkylation macrocyclization, Yang Weibo, 2022 Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp(3))-H olefination mediated by donor/donor carbenes, Yang Weibo, 2021 Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols, Yang Weibo, 2021 Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses, Yang Weibo, 2021 Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors, Yang Weibo, 2020 Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis, Yang Weibo, 2020 A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation, Yang Weibo, 2020 Vinylethylene Carbonates as alpha,beta-Unsaturated Aldehyde Surrogates for Regioselective 3+3 Cycloaddition, Yang Weibo, 2019 Diversity-Orientated Stereoselective Synthesis through Pd-Catalyzed Switchable Decarboxylative C-N/C-S Bond Formation in Allylic Surrogates, Yang Weibo, 2018 Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates, Yang Weibo, 2018 Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives, Yang Weibo, 2018 Orchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles, Yang Weibo, 2015 Mechanistic insights into the gold chemistry of allenes, Yang Weibo, 2014 Dehydrogenative Meyer-Schuster-Like Rearrangement: A Gold-Catalyzed Reaction Generating an Alkyne, Yang Weibo, 2014 Gold-Catalyzed Formal 1,6-Acyloxy Migration Leading to 3,4-Disubstituted Pyrrolidin-2-ones, Yang Weibo, 2013 In Situ Generation of Nucleophilic Allenes by the Gold-Catalyzed Rearrangement of Propargylic Esters for the Highly Diastereoselective Formation of Intermolecular C(sp(3))-C(sp(2)) Bonds, Yang Weibo, 2013 Gold(I)-Catalyzed Formation of Benzobfurans from 3-Silyloxy-1,5-enynes, Yang Weibo, 2011 Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes, Yang Weibo

Areas of Focus

Organometallic Chemistry
Medicinal Chemistry

Publications

Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance, Yang Weibo, 2023
Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C-H activation: Macrocyclic oxime inhibitor of influenza H1N1, Yang Weibo, 2023
Rhodium(III)-Catalyzed C-H/O-2 Dual Activation and Macrocyclization: Synthesis and Evaluation of Pyrido2,1-aisoindole Grafted Macrocyclic Inhibitors for Influenza H1N1, Yang Weibo, 2023
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis, Yang Weibo, 2022
Natural scaffolds-inspired synthesis of CF_(3)-substituted macrolides enabled by Rh-catalyzed C–H alkylation macrocyclization, Yang Weibo, 2022
Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp(3))-H olefination mediated by donor/donor carbenes, Yang Weibo, 2021
Rh-Catalyzed cascade C-H activation/C-C cleavage/cyclization of carboxylic acids with cyclopropanols, Yang Weibo, 2021
Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses, Yang Weibo, 2021
Pd-Catalyzed Decarboxylative Olefination: Stereoselective Synthesis of Polysubstituted Butadienes and Macrocyclic P-glycoprotein Inhibitors, Yang Weibo, 2020
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis, Yang Weibo, 2020
A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation, Yang Weibo, 2020
Vinylethylene Carbonates as alpha,beta-Unsaturated Aldehyde Surrogates for Regioselective 3+3 Cycloaddition, Yang Weibo, 2019
Diversity-Orientated Stereoselective Synthesis through Pd-Catalyzed Switchable Decarboxylative C-N/C-S Bond Formation in Allylic Surrogates, Yang Weibo, 2018
Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates, Yang Weibo, 2018
Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives, Yang Weibo, 2018
Orchestrated Triple C-H Activation Reactions Using Two Directing Groups: Rapid Assembly of Complex Pyrazoles, Yang Weibo, 2015
Mechanistic insights into the gold chemistry of allenes, Yang Weibo, 2014
Dehydrogenative Meyer-Schuster-Like Rearrangement: A Gold-Catalyzed Reaction Generating an Alkyne, Yang Weibo, 2014
Gold-Catalyzed Formal 1,6-Acyloxy Migration Leading to 3,4-Disubstituted Pyrrolidin-2-ones, Yang Weibo, 2013
In Situ Generation of Nucleophilic Allenes by the Gold-Catalyzed Rearrangement of Propargylic Esters for the Highly Diastereoselective Formation of Intermolecular C(sp(3))-C(sp(2)) Bonds, Yang Weibo, 2013
Gold(I)-Catalyzed Formation of Benzobfurans from 3-Silyloxy-1,5-enynes, Yang Weibo, 2011
Marine furanocembranoids-inspired macrocycles enabled by Pd-catalyzed unactivated C(sp3)-H olefination mediated by donor/donor carbenes, Yang Weibo

Organometallic Chemistry Medicinal Chemistry Catalysis Macrocycles Drug Discovery C-H Activation Transition Metals Synthesis Inhibitors Natural Products

Hui-Xiong Dai - University of Chinese Academy of Sciences

Bing Zhou - University of Chinese Academy of Sciences

Youquan Zou - Wuhan University

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