Areas of Focus
- Medicinal Chemistry
- Organic Synthesis
- Drug Synthesis Process
Work Experience
- 1998-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Group Leader, Former Director of Medicinal Chemistry Department
- 1996-09~1998-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral
- 1993-09~1996-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
- 1990-09~1993-08 - Xi'an Modern Chemistry Research Institute - Engineer
- 1987-09~1990-09 - Sichuan University - Master's
- 1983-09~1987-08 - Sichuan University - Bachelor's
Academic Background & Achievements
- 1996-09--1998-08 Postdoctoral: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1993-09--1996-08 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1987-09--1990-09 Master's: Sichuan University
- 1983-09--1987-08 Bachelor's: Sichuan University
Publications
- Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria., J. Med.Chem., 2023
- Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer, J. Med.Chem., 2023
- Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria., J. Med.Chem., 2023
- Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer, J. Med. Chem., 2022
- Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity, JOURNAL OF MEDICINAL CHEMISTRY, 2022
- Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, JOURNAL OF MEDICINAL CHEMISTRY, 2022
- Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, CHEMISTRYSELECT, 2021
- Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer, BIOORGANIC & MEDICINAL CHEMISTRY, 2021
- Recent advances in antibacterial agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021
- Synthesis and Antiplatelet Activities of Novel Bicyclic Pyridine Compounds, 合成化学, 2021
- Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, JOURNAL OF MEDICINAL CHEMISTRY, 2019
- Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019
- Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, JOURNAL OF MEDICINAL CHEMISTRY, 2019
- Synthesis and Biological Evaluation of Oxopyrido2,3-d Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors, LETTERS IN DRUG DESIGN & DISCOVERY, 2019
- Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents, ARCHIV DER PHARMAZIE, 2019
- Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018
- Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018
- Design, synthesis and biological evaluation of C(4) substituted monobactams as antibacterial agents against multidrug-resistant Gram-negative bacteria, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
- Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, BIOORGANIC & MEDICINAL CHEMISTRY, 2018
- Improved laboratory synthesis of yc-071, a potent azole antifungal agent, JOURNAL OF CHEMICAL RESEARCH, 2017
- Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections, JOURNALOFMEDICINALCHEMISTRY, 2017
- Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, CHINESE CHEMICAL LETTERS, 2016
- Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid, 合成化学, 2016
- Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain, CHINESE CHEMICAL LETTERS, 2016
- Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents, CHINESE CHEMICAL LETTERS, 2016
- Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015
- Design, synthesis, and structureeactivity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates
Awards
- National Science and Technology Invention Award, Second Prize, National Level, 2017
- Pudong New Area Science and Technology Innovation Achievement Award, Other, 2017
- National Class 1.1 New Drug Hydrochloride Andoxacin, First Prize, Municipal Level, 2015
- China Pharmaceutical Development Award for Outstanding Achievement in Innovative Drugs, Other, 2013
- IBC China Drug Award, Other, 2010
- Shanghai Advanced Worker Title (Model Worker), Provincial Level, 2010
- China International Industry Award, Other, 2009
- WuXi AppTec Life Science Award, Other, 2007
- Research and Application of Modern Drug Screening System and High-Throughput Screening Technology, Second Prize, National Level, 2003
- Shanghai Excellent Qiming Award, Municipal Level, 2001
- Chinese Academy of Sciences Natural Science Award, Second Prize, Institute Level, 2000
- Shanghai Excellent Doctoral Dissertation Award, Municipal Level, 1999
- Meiji Dairy Youth Award, Other, 1998
- First Chinese Academy of Sciences Award, Institute Level, 1998
