1996-09--1998-08 Postdoctoral: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1993-09--1996-08 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1987-09--1990-09 Master's: Sichuan University
1983-09--1987-08 Bachelor's: Sichuan University
1998-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Group Leader, Former Director of Medicinal Chemistry Department
1996-09~1998-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral
1993-09~1996-08 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
1990-09~1993-08 - Xi'an Modern Chemistry Research Institute - Engineer
1987-09~1990-09 - Sichuan University - Master's
1983-09~1987-08 - Sichuan University - Bachelor's
National Science and Technology Invention Award, Second Prize, National Level, 2017
Pudong New Area Science and Technology Innovation Achievement Award, Other, 2017
National Class 1.1 New Drug Hydrochloride Andoxacin, First Prize, Municipal Level, 2015
China Pharmaceutical Development Award for Outstanding Achievement in Innovative Drugs, Other, 2013
IBC China Drug Award, Other, 2010
Shanghai Advanced Worker Title (Model Worker), Provincial Level, 2010
China International Industry Award, Other, 2009
WuXi AppTec Life Science Award, Other, 2007
Research and Application of Modern Drug Screening System and High-Throughput Screening Technology, Second Prize, National Level, 2003
Shanghai Excellent Qiming Award, Municipal Level, 2001
Chinese Academy of Sciences Natural Science Award, Second Prize, Institute Level, 2000
Shanghai Excellent Doctoral Dissertation Award, Municipal Level, 1999
Meiji Dairy Youth Award, Other, 1998
First Chinese Academy of Sciences Award, Institute Level, 1998
Research
Medicinal Chemistry Organic Synthesis Drug Synthesis Process
Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated β-Lactams against Gram-Negative Bacteria., J. Med.Chem., 2023
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer, J. Med.Chem., 2023
Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria., J. Med.Chem., 2023
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer, J. Med. Chem., 2022
Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity, JOURNAL OF MEDICINAL CHEMISTRY, 2022
Discovery of Thieno2,3-eindazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability, JOURNAL OF MEDICINAL CHEMISTRY, 2022
Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent, CHEMISTRYSELECT, 2021
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer, BIOORGANIC & MEDICINAL CHEMISTRY, 2021
Synthesis and Antiplatelet Activities of Novel Bicyclic Pyridine Compounds, 合成化学, 2021
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria, JOURNAL OF MEDICINAL CHEMISTRY, 2019
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzob1,4dioxine, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties, JOURNAL OF MEDICINAL CHEMISTRY, 2019
Synthesis and Biological Evaluation of Oxopyrido2,3-d Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors, LETTERS IN DRUG DESIGN & DISCOVERY, 2019
Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents, ARCHIV DER PHARMAZIE, 2019
Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018
Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018
Design, synthesis and biological evaluation of C(4) substituted monobactams as antibacterial agents against multidrug-resistant Gram-negative bacteria, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
Design and optimization of 2,3-dihydrobenzob1,4dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles, BIOORGANIC & MEDICINAL CHEMISTRY, 2018
Improved laboratory synthesis of yc-071, a potent azole antifungal agent, JOURNAL OF CHEMICAL RESEARCH, 2017
Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections, JOURNALOFMEDICINALCHEMISTRY, 2017
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, CHINESE CHEMICAL LETTERS, 2016
Process Improvement on the Synthesis of (Z) -2-(2-tritylaminothiazol-4-yl) -2-(1,5-dibenzhydryloxy-4-pyridon-2-ylmethoxyimino) acetic Acid, 合成化学, 2016
Design, synthesis and antibacterial activity of novel pleuromutilin derivatives with 4H-pyran-4-one and pyridin-4-one substitution in the C-14 side chain, CHINESE CHEMICAL LETTERS, 2016
Design and synthesis of novel triazole derivatives containing g-lactam as potential antifungal agents, CHINESE CHEMICAL LETTERS, 2016
Synthesis and structure-activity relationship studies of novel 6,6,5 tricyclic oxazolidinone derivatives as potential antibacterial agents, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015
Design, synthesis, and structureeactivity relationship studies of novel thienopyrrolidone derivatives with strong antifungal activity against Aspergillus fumigates
Keywords
Drug DesignChemical SynthesisPharmaceuticalsOrganic ChemistryMedicinal ChemistrySynthesis MethodsDrug DevelopmentChemical ProcessesPharmacologyBiochemistry
