Professor | Caiguang Yang | Asia Growth Partners

Name	Caiguang Yang
Contact Information	yangcg@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Caiguang Yang

Contact Information

yangcg@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1997-09--2002-06 PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 1993-09--1997-06 Bachelor's: Huazhong University of Science and Technology
Awards	Chinese Academy of Sciences Distinguished Researcher Program (2016): Other Ministry of Science and Technology Young and Middle-aged Science and Technology Innovation Leading Talent Program (2015): Other WuXi AppTec Life Chemistry Research (Scholar) Award (2014): Other Shanghai Pujiang Talent Program (2009): Municipal Chinese Academy of Sciences **** (2008): Institute Level Chinese Academy of Sciences President's Excellence Award (2002): Institute Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1997-09--2002-06 PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
1993-09--1997-06 Bachelor's: Huazhong University of Science and Technology

Awards

Chinese Academy of Sciences Distinguished Researcher Program (2016): Other
Ministry of Science and Technology Young and Middle-aged Science and Technology Innovation Leading Talent Program (2015): Other
WuXi AppTec Life Chemistry Research (Scholar) Award (2014): Other
Shanghai Pujiang Talent Program (2009): Municipal
Chinese Academy of Sciences **** (2008): Institute Level
Chinese Academy of Sciences President's Excellence Award (2002): Institute Level

Areas of Focus	Chemical probe research on key enzymes of RNA methylation modification Small molecule regulation of protein interactions in the ubiquitination modification signaling pathway and its anti-tumor research Research on new types of antibiotics and the use of 'non-antibiotic effects' to control pathogenic bacterial infections
Publications	Structural insights into the evolutionary simplification of human ClpP activators, LinLin Zhou, CaiGuang Yang, 2023 Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties, Pan Xiao, Zongliang Duan, Zeyu Liu, Liang Chen, Deyan Zhang, Lu Liu, Chen Zhou, Jianhua Gan, Ze Dong, Cai-Guang Yang, 2023 Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents, Zhu, Heping, Song, Xiaomin, Pan, Yihui, Li, Ming, Chen, Liang, Xiao, Pan, Du, Rong, Dong, Ze, Yang, CaiGuang, 2023 化学干预N^（6）-甲基腺嘌呤修饰的研究进展, 郇歆宇, 赖淦强, 黄悦, 杨财广, 2023 Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists, Zhang, Ranran, Wang, Pengyu, Wei, Bingyan, Chen, Liang, Song, Xiaomin, Pan, Yihui, Li, Jiahui, Gan, Jianhua, Zhang, Tao, Yang, CaiGuang, 2023 Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP, Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, CaiGuang Yang, 2022 一个新的感应铜离子的双组分信号转导系统, 余梁, 曹荞, 陈未中, 杨娜娜, 杨财广, 季泉江, 吴敏, Taeok, Bae, 蓝乐夫, 2022 Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors, Liu, Zeyu, Duan, Zongliang, Zhang, Deyan, Xiao, Pan, Zhang, Tao, Xu, Hongjiao, Wang, ChuanHui, Rao, GuoWu, Gan, Jianhua, Huang, Yue, Yang, CaiGuang, Dong, Ze, 2022 化学生物学2017~2021年回顾及未来发展规划, 邢曦雯, 杨财广, 杨俊林, 张艳, 2022 Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma, Wang, Pengyu, Zhang, Tao, Wang, Xinjing, Xiao, Hongying, Li, Huiti, Shou, LinLin, Yang, Teng, Wei, Bingyan, Zhu, Zeyun, Zhou, Lu, Yang, Song, Lu, Xiongxiong, Zhang, Yonghui, Huang, Yue, Gan, Jianhua, Yang, CaiGuang, 2022 Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus(dagger), Yu, ChenXi, Wei, BingYan, Kong, XueQing, Yang, CaiGuang, Nan, FaJun, 2021 Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer, Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P, Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, CaiGuang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M, Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A, Zwart, Wilbert, Kruithofde Julio, Marianna, Rubin, Mark A, Udeshi, Namrata D, Theurillat, JeanPhilippe P, 2021 Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections, Yang, Teng, Zhang, Tao, Zhou, Xiang, Wang, Pengyu, Gan, Jianhua, Song, Baoan, Yang, Song, Yang, CaiGuang, 2021 Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa, Wang, Yaya, Cao, Qiao, Cao, Qin, Gan, Jianhua, Sun, Ning, Yang, CaiGuang, Bae, Taeok, Wu, Min, Lan, Lefu, 2021 Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance, Liu, Yi, Liang, Guanghao, Xu, Hongjiao, Dong, Wenxin, Dong, Ze, Qiu, Zhiwei, Zhang, Zihao, Li, Fangle, Huang, Yue, Li, Yilin, Wu, Jun, Yin, Shenyi, Zhang, Yawei, Guo, Peijin, Liu, Jun, Xi, Jianzhong Jeff, Jiang, Peng, Han, Dali, Yang, CaiGuang, Xu, Meng Michelle, 2021 A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells, Wang, Zhen, Zhang, Hao, Chen, Baoen, Ouyang, Sisheng, Zheng, Tong, Zhou, Ran, Dong, Ze, Huang, Yue, Zhang, Tao, Jiang, Hualiang, Gan, Jianhua, Luo, Cheng, Yang, CaiGuang, 2021 Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer, Dong, Ze, Wang, Zhen, Guo, ZhongQiang, Gong, Shouzhe, Zhang, Tao, Liu, Jiang, Luo, Cheng, Jiang, Hualiang, Yang, CaiGuang, 2020 Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators, Kong, XueQing, Wei, BingYan, Yu, ChenXi, Guan, XiangNa, Ma, WeiPing, Liu, Gang, Yang, CaiGuang, Nan, FaJun, 2020 Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA, Yang, Teng, Zhang, Tao, Guan, XiangNa, Dong, Ze, Lan, Lefu, Yang, Song, Yang, CaiGuang, 2020 RNA Methylation m(6)A: A New Code and Drug Target?, Lai, GanQiang, Zhou, LinLin, Yang, CaiGuang, 2020 Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Song, Runzhe, Wang, Yue, Wang, Minghui, Gao, Ruixuan, Yang, Teng, Yang, Song, Yang, CaiGuang, Jin, Yongsheng, Zou, Siyuan, Cai, Jianfeng, Fan, Renhua, He, Qiuqin, 2020 Targeting Epitranscriptomic Proteins for Therapeutic Intervention, Zhou, LinLin, Yang, CaiGuang, 2020 Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis, Gu, Lei, Liu, Xing, Wang, YuQiu, Zhou, Yanting, Zhu, Hongwen, Huang, Jin, Lan, Lefu, Zheng, Jing, Yang, Caiguang, Zhou, Hu, 2020 Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus, Wang, ZhiCheng, Wei, Bingyan, Pei, FangNing, Yang, Teng, Tang, Jie, Yang, Song, Yu, LiFang, Yang, CaiGuang, Yang, Fan, 2020 Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus, Yang, Nana, Cao, Qiao, Hu, Shuyang, Xu, Chenchen, Fan, Ke, Chen, Feifei, Yang, CaiGuang, Liang, Haihua, Wu, Min, Bae, Taeok, Lan, Lefu, 2020 Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates, Cao, Qiao, Yang, Nana, Wang, Yanhui, Xu, Chenchen, Zhang, Xue, Fan, Ke, Chen, Feifei, Liang, Haihua, Zhang, Yingchao, Deng, Xin, Feng, Youjun, Yang, CaiGuang, Wu, Min, Bae, Taeok, Lan, Lefu, 2020 Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents, Su, Liqiang, Li, Jiahui, Zhou, Zhen, Huang, Dongxia, Zhang, Yuanjin, Pei, Haixiang, Guo, Weikai, Wu, Haigang, Wang, Xin, Liu, Mingyao, Yang, CaiGuang, Chen, Yihua, 2019 Single

Areas of Focus

Chemical probe research on key enzymes of RNA methylation modification
Small molecule regulation of protein interactions in the ubiquitination modification signaling pathway and its anti-tumor research
Research on new types of antibiotics and the use of 'non-antibiotic effects' to control pathogenic bacterial infections

Publications

Structural insights into the evolutionary simplification of human ClpP activators, LinLin Zhou, CaiGuang Yang, 2023
Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties, Pan Xiao, Zongliang Duan, Zeyu Liu, Liang Chen, Deyan Zhang, Lu Liu, Chen Zhou, Jianhua Gan, Ze Dong, Cai-Guang Yang, 2023
Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents, Zhu, Heping, Song, Xiaomin, Pan, Yihui, Li, Ming, Chen, Liang, Xiao, Pan, Du, Rong, Dong, Ze, Yang, CaiGuang, 2023
化学干预N^（6）-甲基腺嘌呤修饰的研究进展, 郇歆宇, 赖淦强, 黄悦, 杨财广, 2023
Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists, Zhang, Ranran, Wang, Pengyu, Wei, Bingyan, Chen, Liang, Song, Xiaomin, Pan, Yihui, Li, Jiahui, Gan, Jianhua, Zhang, Tao, Yang, CaiGuang, 2023
Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP, Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, CaiGuang Yang, 2022
一个新的感应铜离子的双组分信号转导系统, 余梁, 曹荞, 陈未中, 杨娜娜, 杨财广, 季泉江, 吴敏, Taeok, Bae, 蓝乐夫, 2022
Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors, Liu, Zeyu, Duan, Zongliang, Zhang, Deyan, Xiao, Pan, Zhang, Tao, Xu, Hongjiao, Wang, ChuanHui, Rao, GuoWu, Gan, Jianhua, Huang, Yue, Yang, CaiGuang, Dong, Ze, 2022
化学生物学2017~2021年回顾及未来发展规划, 邢曦雯, 杨财广, 杨俊林, 张艳, 2022
Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma, Wang, Pengyu, Zhang, Tao, Wang, Xinjing, Xiao, Hongying, Li, Huiti, Shou, LinLin, Yang, Teng, Wei, Bingyan, Zhu, Zeyun, Zhou, Lu, Yang, Song, Lu, Xiongxiong, Zhang, Yonghui, Huang, Yue, Gan, Jianhua, Yang, CaiGuang, 2022
Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus(dagger), Yu, ChenXi, Wei, BingYan, Kong, XueQing, Yang, CaiGuang, Nan, FaJun, 2021
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer, Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P, Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, CaiGuang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M, Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A, Zwart, Wilbert, Kruithofde Julio, Marianna, Rubin, Mark A, Udeshi, Namrata D, Theurillat, JeanPhilippe P, 2021
Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections, Yang, Teng, Zhang, Tao, Zhou, Xiang, Wang, Pengyu, Gan, Jianhua, Song, Baoan, Yang, Song, Yang, CaiGuang, 2021
Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa, Wang, Yaya, Cao, Qiao, Cao, Qin, Gan, Jianhua, Sun, Ning, Yang, CaiGuang, Bae, Taeok, Wu, Min, Lan, Lefu, 2021
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance, Liu, Yi, Liang, Guanghao, Xu, Hongjiao, Dong, Wenxin, Dong, Ze, Qiu, Zhiwei, Zhang, Zihao, Li, Fangle, Huang, Yue, Li, Yilin, Wu, Jun, Yin, Shenyi, Zhang, Yawei, Guo, Peijin, Liu, Jun, Xi, Jianzhong Jeff, Jiang, Peng, Han, Dali, Yang, CaiGuang, Xu, Meng Michelle, 2021
A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells, Wang, Zhen, Zhang, Hao, Chen, Baoen, Ouyang, Sisheng, Zheng, Tong, Zhou, Ran, Dong, Ze, Huang, Yue, Zhang, Tao, Jiang, Hualiang, Gan, Jianhua, Luo, Cheng, Yang, CaiGuang, 2021
Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer, Dong, Ze, Wang, Zhen, Guo, ZhongQiang, Gong, Shouzhe, Zhang, Tao, Liu, Jiang, Luo, Cheng, Jiang, Hualiang, Yang, CaiGuang, 2020
Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators, Kong, XueQing, Wei, BingYan, Yu, ChenXi, Guan, XiangNa, Ma, WeiPing, Liu, Gang, Yang, CaiGuang, Nan, FaJun, 2020
Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA, Yang, Teng, Zhang, Tao, Guan, XiangNa, Dong, Ze, Lan, Lefu, Yang, Song, Yang, CaiGuang, 2020
RNA Methylation m(6)A: A New Code and Drug Target?, Lai, GanQiang, Zhou, LinLin, Yang, CaiGuang, 2020
Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Song, Runzhe, Wang, Yue, Wang, Minghui, Gao, Ruixuan, Yang, Teng, Yang, Song, Yang, CaiGuang, Jin, Yongsheng, Zou, Siyuan, Cai, Jianfeng, Fan, Renhua, He, Qiuqin, 2020
Targeting Epitranscriptomic Proteins for Therapeutic Intervention, Zhou, LinLin, Yang, CaiGuang, 2020
Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis, Gu, Lei, Liu, Xing, Wang, YuQiu, Zhou, Yanting, Zhu, Hongwen, Huang, Jin, Lan, Lefu, Zheng, Jing, Yang, Caiguang, Zhou, Hu, 2020
Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus, Wang, ZhiCheng, Wei, Bingyan, Pei, FangNing, Yang, Teng, Tang, Jie, Yang, Song, Yu, LiFang, Yang, CaiGuang, Yang, Fan, 2020
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus, Yang, Nana, Cao, Qiao, Hu, Shuyang, Xu, Chenchen, Fan, Ke, Chen, Feifei, Yang, CaiGuang, Liang, Haihua, Wu, Min, Bae, Taeok, Lan, Lefu, 2020
Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates, Cao, Qiao, Yang, Nana, Wang, Yanhui, Xu, Chenchen, Zhang, Xue, Fan, Ke, Chen, Feifei, Liang, Haihua, Zhang, Yingchao, Deng, Xin, Feng, Youjun, Yang, CaiGuang, Wu, Min, Bae, Taeok, Lan, Lefu, 2020
Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents, Su, Liqiang, Li, Jiahui, Zhou, Zhen, Huang, Dongxia, Zhang, Yuanjin, Pei, Haixiang, Guo, Weikai, Wu, Haigang, Wang, Xin, Liu, Mingyao, Yang, CaiGuang, Chen, Yihua, 2019
Single

Rna Methylation Chemical Probe Key Enzymes Ubiquitination Protein Interactions Small Molecules Anti-Tumor New Antibiotics Non-Antibiotic Effects Pathogenic Bacteria

Changming Zhao - Wuhan University

Wei Wang - Wuhan University

Naixia Zhang - University of Chinese Academy of Sciences

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