Areas of Focus
- Chemical probe research on key enzymes of RNA methylation modification
- Small molecule regulation of protein interactions in the ubiquitination modification signaling pathway and its anti-tumor research
- Research on new types of antibiotics and the use of 'non-antibiotic effects' to control pathogenic bacterial infections
Academic Background & Achievements
- 1997-09--2002-06 PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- 1993-09--1997-06 Bachelor's: Huazhong University of Science and Technology
Publications
- Structural insights into the evolutionary simplification of human ClpP activators, LinLin Zhou, CaiGuang Yang, 2023
- Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties, Pan Xiao, Zongliang Duan, Zeyu Liu, Liang Chen, Deyan Zhang, Lu Liu, Chen Zhou, Jianhua Gan, Ze Dong, Cai-Guang Yang, 2023
- Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents, Zhu, Heping, Song, Xiaomin, Pan, Yihui, Li, Ming, Chen, Liang, Xiao, Pan, Du, Rong, Dong, Ze, Yang, CaiGuang, 2023
- 化学干预N^（6）-甲基腺嘌呤修饰的研究进展, 郇歆宇, 赖淦强, 黄悦, 杨财广, 2023
- Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists, Zhang, Ranran, Wang, Pengyu, Wei, Bingyan, Chen, Liang, Song, Xiaomin, Pan, Yihui, Li, Jiahui, Gan, Jianhua, Zhang, Tao, Yang, CaiGuang, 2023
- Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP, Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, CaiGuang Yang, 2022
- 一个新的感应铜离子的双组分信号转导系统, 余梁, 曹荞, 陈未中, 杨娜娜, 杨财广, 季泉江, 吴敏, Taeok, Bae, 蓝乐夫, 2022
- Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors, Liu, Zeyu, Duan, Zongliang, Zhang, Deyan, Xiao, Pan, Zhang, Tao, Xu, Hongjiao, Wang, ChuanHui, Rao, GuoWu, Gan, Jianhua, Huang, Yue, Yang, CaiGuang, Dong, Ze, 2022
- 化学生物学2017~2021年回顾及未来发展规划, 邢曦雯, 杨财广, 杨俊林, 张艳, 2022
- Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma, Wang, Pengyu, Zhang, Tao, Wang, Xinjing, Xiao, Hongying, Li, Huiti, Shou, LinLin, Yang, Teng, Wei, Bingyan, Zhu, Zeyun, Zhou, Lu, Yang, Song, Lu, Xiongxiong, Zhang, Yonghui, Huang, Yue, Gan, Jianhua, Yang, CaiGuang, 2022
- Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus(dagger), Yu, ChenXi, Wei, BingYan, Kong, XueQing, Yang, CaiGuang, Nan, FaJun, 2021
- Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer, Bernasocchi, Tiziano, El Tekle, Geniver, Bolis, Marco, Mutti, Azzurra, Vallerga, Arianna, Brandt, Laura P, Spriano, Filippo, Svinkina, Tanya, Zoma, Marita, Ceserani, Valentina, Rinaldi, Anna, Janouskova, Hana, Bossi, Daniela, Cavalli, Manuela, Mosole, Simone, Geiger, Roger, Dong, Ze, Yang, CaiGuang, Albino, Domenico, Rinaldi, Andrea, Schraml, Peter, Linder, Simon, Carbone, Giuseppina M, Alimonti, Andrea, Bertoni, Francesco, Moch, Holger, Carr, Steven A, Zwart, Wilbert, Kruithofde Julio, Marianna, Rubin, Mark A, Udeshi, Namrata D, Theurillat, JeanPhilippe P, 2021
- Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections, Yang, Teng, Zhang, Tao, Zhou, Xiang, Wang, Pengyu, Gan, Jianhua, Song, Baoan, Yang, Song, Yang, CaiGuang, 2021
- Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa, Wang, Yaya, Cao, Qiao, Cao, Qin, Gan, Jianhua, Sun, Ning, Yang, CaiGuang, Bae, Taeok, Wu, Min, Lan, Lefu, 2021
- Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance, Liu, Yi, Liang, Guanghao, Xu, Hongjiao, Dong, Wenxin, Dong, Ze, Qiu, Zhiwei, Zhang, Zihao, Li, Fangle, Huang, Yue, Li, Yilin, Wu, Jun, Yin, Shenyi, Zhang, Yawei, Guo, Peijin, Liu, Jun, Xi, Jianzhong Jeff, Jiang, Peng, Han, Dali, Yang, CaiGuang, Xu, Meng Michelle, 2021
- A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells, Wang, Zhen, Zhang, Hao, Chen, Baoen, Ouyang, Sisheng, Zheng, Tong, Zhou, Ran, Dong, Ze, Huang, Yue, Zhang, Tao, Jiang, Hualiang, Gan, Jianhua, Luo, Cheng, Yang, CaiGuang, 2021
- Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer, Dong, Ze, Wang, Zhen, Guo, ZhongQiang, Gong, Shouzhe, Zhang, Tao, Liu, Jiang, Luo, Cheng, Jiang, Hualiang, Yang, CaiGuang, 2020
- Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators, Kong, XueQing, Wei, BingYan, Yu, ChenXi, Guan, XiangNa, Ma, WeiPing, Liu, Gang, Yang, CaiGuang, Nan, FaJun, 2020
- Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA, Yang, Teng, Zhang, Tao, Guan, XiangNa, Dong, Ze, Lan, Lefu, Yang, Song, Yang, CaiGuang, 2020
- RNA Methylation m(6)A: A New Code and Drug Target?, Lai, GanQiang, Zhou, LinLin, Yang, CaiGuang, 2020
- Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Song, Runzhe, Wang, Yue, Wang, Minghui, Gao, Ruixuan, Yang, Teng, Yang, Song, Yang, CaiGuang, Jin, Yongsheng, Zou, Siyuan, Cai, Jianfeng, Fan, Renhua, He, Qiuqin, 2020
- Targeting Epitranscriptomic Proteins for Therapeutic Intervention, Zhou, LinLin, Yang, CaiGuang, 2020
- Revelation of AbfR in regulation of mismatch repair and energy metabolism in S. epidermidis by integrated proteomic and metabolomic analysis, Gu, Lei, Liu, Xing, Wang, YuQiu, Zhou, Yanting, Zhu, Hongwen, Huang, Jin, Lan, Lefu, Zheng, Jing, Yang, Caiguang, Zhou, Hu, 2020
- Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus, Wang, ZhiCheng, Wei, Bingyan, Pei, FangNing, Yang, Teng, Tang, Jie, Yang, Song, Yu, LiFang, Yang, CaiGuang, Yang, Fan, 2020
- Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus, Yang, Nana, Cao, Qiao, Hu, Shuyang, Xu, Chenchen, Fan, Ke, Chen, Feifei, Yang, CaiGuang, Liang, Haihua, Wu, Min, Bae, Taeok, Lan, Lefu, 2020
- Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates, Cao, Qiao, Yang, Nana, Wang, Yanhui, Xu, Chenchen, Zhang, Xue, Fan, Ke, Chen, Feifei, Liang, Haihua, Zhang, Yingchao, Deng, Xin, Feng, Youjun, Yang, CaiGuang, Wu, Min, Bae, Taeok, Lan, Lefu, 2020
- Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents, Su, Liqiang, Li, Jiahui, Zhou, Zhen, Huang, Dongxia, Zhang, Yuanjin, Pei, Haixiang, Guo, Weikai, Wu, Haigang, Wang, Xin, Liu, Mingyao, Yang, CaiGuang, Chen, Yihua, 2019
- Single
Awards
- Chinese Academy of Sciences Distinguished Researcher Program (2016): Other
- Ministry of Science and Technology Young and Middle-aged Science and Technology Innovation Leading Talent Program (2015): Other
- WuXi AppTec Life Chemistry Research (Scholar) Award (2014): Other
- Shanghai Pujiang Talent Program (2009): Municipal
- Chinese Academy of Sciences **** (2008): Institute Level
- Chinese Academy of Sciences President's Excellence Award (2002): Institute Level
