2003-09--2008-07 PhD: Shenyang Pharmaceutical University
1999-09--2003-07 Bachelor's Degree: Shenyang Pharmaceutical University
2019-10~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Group Leader, Doctoral Supervisor
2016-09~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher, Master's Supervisor (2012), Doctoral Supervisor (2018)
2010-09~2016-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2010-07~2010-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
2008-07~2010-07 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
First Prize of the 16th China Pharmaceutical Association Science and Technology Award (2021)
First Prize of Shanghai Science and Technology Progress Award (2020)
21st China Patent Excellence Award (2020)
First Prize of Shanghai Pharmaceutical Science and Technology Award (2020)
SANOFI-SIBS Outstanding Talent Award (2016)
First Batch of Outstanding Members of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2015)
First Prize of Shanghai Pharmaceutical Science and Technology Award (2015)
Special Prize of the 14th 'China Pharmaceutical Association-Servier Young Medicinal Chemist Award' (2011)
Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2011)
Research
Drug Chemistry
A Ru(ii)-catalyzed C-H activation and annulation cascade for the construction of highly coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones, 11th Author, 2023
Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, 11th Author, 2023
Copper-Catalyzed Synthesis of alpha-Keto Amides from Sulfoxonium Ylides, 11th Author, 2023
Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles, 11th Author, 2023
Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice, 11th Author, 2022
A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds, 11th Author, 2022
Recyclable rhodium-catalyzed C-H activation/4+2 annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight, 11th Author, 2022
A substrate-controlled Ru(ii)-catalyzed C-H activation/5+2 annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds, 11th Author, 2022
Rh(III)-Catalyzed C-H Activation and 4+1+1 Sequential Cyclization Cascade to Give Highly Fused Indano1,2-bazirines, 11th Author, 2022
LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer disease, 11th Author, 2022
A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde, 11th Author, 2021
A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones, 11th Author, 2021
Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones, 11th Author, 2021
I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines, 11th Author, 2021
Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides, 11th Author, 2021
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers, 1st Author, 2021
Rh(III)-Catalyzed 5+1 Annulation of Indole-enaminones with Diazo Compounds To Form Highly Functionalized Carbazoles, 11th Author, 2021
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, 1st Author, 2021
A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde, 11th Author, 2021
Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused PyranodeIsochromenes, 11th Author, 2020
Rhodium(III)-Catalyzed Redox-Neutral 3+3 Annulation of N -nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1 H )-One Scaffolds, 11th Author, 2020
Ruthenium-Catalyzed C-H Activations for the Synthesis of Indole Derivatives, 3rd Author, 2020
A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines, 11th Author, 2020
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4, 14th Author, 2020
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, 11th Author, 2020
Synthesis of Highly Fused Pyrano2,3-bpyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature, 11th Author, 2020
Rh(III)-Catalyzed C-H Bond Activation for the Construction of Heterocycles with sp(3)-Carbon Centers, 11th Author, 2019
Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity, 6th Author, 2019
N-Heterocyclic Carbene Catalyzed Enantioselective 3+2 Dearomatizing Annulation of Saturated Carboxylic Esters with N-Iminoisoquinolinium Ylides, 2nd Author, 2018
Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzodechromenes, 11th Author, 2018
Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Cyclization with Sulfoxonium Ylides to Naphthols., 11th Author, 2018
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, 13th Author, 2018
Catalytic and catalyst-free diboration of alkynes, 5th Author, 2017
Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, 3rd Author, 2017
Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation, 11th Author, 2017
Absolute Configuration of Periplosides C and F and Isolation of Minor Spiro-orthoester Group-Containing Pregnane-type Steroidal Glycosides from Periploca sepium and Their T-Lymphocyte Proliferation Inhibitory Activities, 4th Author, 2017
Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions, 11th Author, 2017
Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review, 2nd Author, 2017
Keywords
Drug DesignSynthesisPharmacologyMedicinal ChemistryBioorganic ChemistryPharmaceuticalsTherapeuticsChemical BiologyOrganic SynthesisDrug Discovery
Area of Focus
Drug Synthesis | Organic Chemistry | Pharmaceutical Chemistry | Chemical Synthesis | Medicinal Chemistry | Drug Development | Synthetic Methods | Chemical Reactions | Molecular Design | Bioorganic Chemistry
