Areas of Focus
- Drug Chemistry
Work Experience
- 2019-10~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Group Leader, Doctoral Supervisor
- 2016-09~Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher, Master's Supervisor (2012), Doctoral Supervisor (2018)
- 2010-09~2016-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
- 2010-07~2010-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
- 2008-07~2010-07 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
Academic Background & Achievements
- 2003-09--2008-07 PhD: Shenyang Pharmaceutical University
- 1999-09--2003-07 Bachelor's Degree: Shenyang Pharmaceutical University
Publications
- A Ru(ii)-catalyzed C-H activation and annulation cascade for the construction of highly coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones, 11th Author, 2023
- Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment, 11th Author, 2023
- Copper-Catalyzed Synthesis of alpha-Keto Amides from Sulfoxonium Ylides, 11th Author, 2023
- Rh(III)-Catalyzed Successive C-H Activations of 2-Phenyl-3H-indoles and Cyclization Cascades to Construct Highly Fused Indole Heteropolycycles, 11th Author, 2023
- Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice, 11th Author, 2022
- A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp(3))-H Bonds, 11th Author, 2022
- Recyclable rhodium-catalyzed C-H activation/4+2 annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight, 11th Author, 2022
- A substrate-controlled Ru(ii)-catalyzed C-H activation/5+2 annulation cascade and unusual acyl migration to synthesize diverse indoline scaffolds, 11th Author, 2022
- Rh(III)-Catalyzed C-H Activation and 4+1+1 Sequential Cyclization Cascade to Give Highly Fused Indano1,2-bazirines, 11th Author, 2022
- LYECs: lysosome-enhancing compounds as potential therapeutic approaches for Alzheimer disease, 11th Author, 2022
- A metal-free method for the facile synthesis of indanones via the intramotecular hydroacylation of 2-vinytbenzaldehyde, 11th Author, 2021
- A Rh(iii)-catalyzed C-H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylidene-isochromanones, 11th Author, 2021
- Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones, 11th Author, 2021
- I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines, 11th Author, 2021
- Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides, 11th Author, 2021
- Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers, 1st Author, 2021
- Rh(III)-Catalyzed 5+1 Annulation of Indole-enaminones with Diazo Compounds To Form Highly Functionalized Carbazoles, 11th Author, 2021
- Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate, 1st Author, 2021
- A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde, 11th Author, 2021
- Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused PyranodeIsochromenes, 11th Author, 2020
- Rhodium(III)-Catalyzed Redox-Neutral 3+3 Annulation of N -nitrosoanilines with Cyclopropenones: A Traceless Approach to Quinolin-4(1 H )-One Scaffolds, 11th Author, 2020
- Ruthenium-Catalyzed C-H Activations for the Synthesis of Indole Derivatives, 3rd Author, 2020
- A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines, 11th Author, 2020
- Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4, 14th Author, 2020
- Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, 11th Author, 2020
- Synthesis of Highly Fused Pyrano2,3-bpyridines via Rh(III)- Catalyzed C-H Activation and Intramolecular Cascade Annulation under Room Temperature, 11th Author, 2020
- Rh(III)-Catalyzed C-H Bond Activation for the Construction of Heterocycles with sp(3)-Carbon Centers, 11th Author, 2019
- Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity, 6th Author, 2019
- N-Heterocyclic Carbene Catalyzed Enantioselective 3+2 Dearomatizing Annulation of Saturated Carboxylic Esters with N-Iminoisoquinolinium Ylides, 2nd Author, 2018
- Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzodechromenes, 11th Author, 2018
- Rh(III)-Catalyzed C-H Activation of Benzoylacetonitriles and Cyclization with Sulfoxonium Ylides to Naphthols., 11th Author, 2018
- Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, 13th Author, 2018
- Catalytic and catalyst-free diboration of alkynes, 5th Author, 2017
- Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, 3rd Author, 2017
- Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation, 11th Author, 2017
- Absolute Configuration of Periplosides C and F and Isolation of Minor Spiro-orthoester Group-Containing Pregnane-type Steroidal Glycosides from Periploca sepium and Their T-Lymphocyte Proliferation Inhibitory Activities, 4th Author, 2017
- Construction of highly enantioenriched spirocyclopentaneoxindoles containing four consecutive stereocenters via thiourea-catalyzed asymmetric Michael-Henry cascade reactions, 11th Author, 2017
- Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review, 2nd Author, 2017
Awards
- First Prize of the 16th China Pharmaceutical Association Science and Technology Award (2021)
- First Prize of Shanghai Science and Technology Progress Award (2020)
- 21st China Patent Excellence Award (2020)
- First Prize of Shanghai Pharmaceutical Science and Technology Award (2020)
- SANOFI-SIBS Outstanding Talent Award (2016)
- First Batch of Outstanding Members of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2015)
- First Prize of Shanghai Pharmaceutical Science and Technology Award (2015)
- Special Prize of the 14th 'China Pharmaceutical Association-Servier Young Medicinal Chemist Award' (2011)
- Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2011)
