1995-01--1996-10 Postdoctoral: Peking University, College of Chemistry and Molecular Engineering
1993-09--1994-12 Postdoctoral: University of Bonn, Institute of Pharmaceutical Research
1990-09--1993-09 PhD: University of Bonn, Institute of Pharmaceutical Research
1984-09--1987-06 Master's: Lanzhou University, Department of Chemistry
1980-09--1984-07 Bachelor's: Sichuan University, Department of Chemistry
1996-10~Present - Chinese Academy of Sciences, Chengdu Institute of Biology - Researcher (1997)
1987-06~1990-09 - Chinese Academy of Sciences, Chengdu Institute of Biology - Assistant Researcher (1989)
Sichuan Provincial Science and Technology Progress Award, First Prize, Provincial Level, 2013
Research
Pharmaceutical Chemistry Pharmacology Chemical Biology
Diterpenes from Dysoxylum lukii Merr, Guolin Zhang, 2019
Metal Ion Coordination Protocol for the Synthesis 2,3-Dehydrosilybin and 19-O-Demethyl-2,3-dehydrosilybin from Silybin and Their Antitumor Activities, Guolin Zhang, 2018
Cytotoxic Lanostane-type C31 Triterpeniod Derivatives from the Fruiting Bodies of Cultivated Fomitopsis palustris, Guolin Zhang, 2018
Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D, Guolin Zhang, 2018
Synthesis of 5-subsituted flavonols via Algar-Flynn-Oyamada (AFO) reaction: the mechanistic implication, Guolin Zhang, 2017
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the antiproliferative effect of interferon α/β by promoting the activation of JAK/STAT signaling through the inhibition of SOCS3 in hepatocellular carcinoma cells, Guolin Zhang, 2017
Two new alkaloids from Melodinus hemsleyanus, Guolin Zhang, 2016
Iridoid glucosides and diterpenoids from Caryopteris glutinosa, Guolin Zhang, 2016
2-Phenylbenzo[b]furans: synthesis and promoting activity on estrogen biosynthesis, Guolin Zhang, 2016
Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement, Guolin Zhang, 2015
Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leaves, Guolin Zhang, 2015
Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates, Guolin Zhang, 2015
Novel Stilbenes from Artocarpus nanchuanensis, Guolin Zhang, 2015
Analysis of sesquiterpene pyridine alkaloids using ESI–MS/MS: The product ion at m/z 310 formed by an ion–dipole intermediate, Guolin Zhang, 2015
Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry, Guolin Zhang, 2015
Copper-Catalyzed Decarboxylative Intramolecular C-O Coupling: Synthesis of 2-Arylbenzofuran from 3-Arylcoumarin, Guolin Zhang, 2014
Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of JAK/STAT Pathway through PKA-Mediated Inhibition of SHP-2 in cancer cells, Guolin Zhang, 2014
Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Guolin Zhang, 2014
Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots of Tripterygium wilfordii, Guolin Zhang, 2014
3-Arylcoumarins Synthesis and potent anti-inflammatory activity, Guolin Zhang, 2014
Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum, Guolin Zhang, 2013
Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19), Guolin Zhang, 2013
Pregnane alkaloids from Sarcococca hookeriana var digyna, Guolin Zhang, 2013
Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum, Guolin Zhang, 2013
Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), Guolin Zhang, 2012
Egonol gentiobioside and egonol gentiotrioside from Styrax perkinsiae promote the biosynthesis of estrogen by aromatase, Guolin Zhang, 2012
Chaetoconvosins A and B, Alkaloids with new skeleton from fungus Chaetomium convolutum, Guolin Zhang, 2012
Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, Guolin Zhang, 2012
Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening, Guolin Zhang, 2012
Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Guolin Zhang, 2012
Toxicity of raw and processed roots of Polygonum multiflorum, Guolin Zhang, 2012
Three new eudesmanolides from Camchaya loloana, Guolin Zhang, 2011
Antiosteoporotic compounds from seeds of Cuscuta chinensis, Guolin Zhang, 2011
Chromones and coumarins from the dried fructus of Cnidium monnieri, Guolin Zhang, 2011
Four New Alkaloids, Brevianamides O–R, from the fungus Aspergillus versicolor, Guolin Zhang, 2010
Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor, Guolin Zhang, 2009
Analysis of epipolythiodioxopiperazines in fungus Chaetomium cochliodes using HPLC-ESI-MS/MS/MS, Guolin Zhang, 2008
Preparation of two diastereomeric decalins synthons and (-)-ambrox, Guolin Zhang, 2008
Electrospray tandem mass spectrometry of epipolythiodioxopiperazines, Guolin Zhang, 2007
Abietane lactones and iridoids from Goldfussia yunnanensis, Guolin Zhang, 2007
Lupane triterpenoids and a diarylhenpoid from Clematoclethra actinidioides, Guolin Zhang, 2006
Chaetoindicins A-C, three isoquinoline alkaloids from fungus Chaetomium indicum, Guolin Zhang, 2006
Synthesis of 4-chloromethyl-2-aryl-5- methyloxazoles, Guolin Zhang, 2006
Chaetocochins A-C: three polythiodioxopiperazines from Chaetomium cochliodes, Guolin Zhang, 2006
Chiral decalins: preparation from oleanolic acid and application in the synthesis of (-)-9-epi-ambrox, Guolin Zhang, 2006
Phenolic and Triterpene Glycosides from the Stems of Ilex litseaefolia, Guolin Zhang, 2005
Novel cadinane and norcadinane sesquiterpenes from Goldfussia psilostachys, Guolin Zhang, 2005
Two diterpenes and three diterpene glucosides from Philogacanthus curviflorus, Guolin Zhang, 2005
Synthesis of
Keywords
Drug DevelopmentOrganic SynthesisBioactive CompoundsMolecular MechanismsPharmacodynamicsPharmacokineticsNatural ProductsMedicinal ChemistryBiochemical PathwaysTherapeutic Agents
