Professor | Yi Zang | Asia Growth Partners

Name	Yi Zang
Contact Information	yzang@lglab.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yi Zang

Contact Information

yzang@lglab.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09--2008-07 Ph.D. in Science: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1996-09--2001-07 Bachelor's in Medicine: Fudan University (formerly Shanghai Medical University)
Work Experience	2017-12~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Doctoral Supervisor 2014-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2011-10~2014-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher 2010-12~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Master's Supervisor 2008-11~2010-07 - M.D. Anderson Cancer Center, USA - Postdoctoral Researcher 2005-07~2010-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher 2001-07~2005-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Research Intern

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09--2008-07 Ph.D. in Science: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1996-09--2001-07 Bachelor's in Medicine: Fudan University (formerly Shanghai Medical University)

Work Experience

2017-12~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Doctoral Supervisor
2014-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2011-10~2014-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
2010-12~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Master's Supervisor
2008-11~2010-07 - M.D. Anderson Cancer Center, USA - Postdoctoral Researcher
2005-07~2010-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
2001-07~2005-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Research Intern

Areas of Focus	Molecular Pharmacology Traditional Chinese Medicine Pharmacology
Publications	Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells, 11th Author, 2023 Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis, 11th Author, 2023 Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, 11th Author, 2022 Synthesis and Biochemical Evaluation of 8H-Indeno1,2-dthiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors, 11th Author, 2022 A Tandemly Activated Fluorescence Probe for Detecting Senescent Cells with Improved Selectivity by Targeting a Biomarker Combination, 11th Author, 2022 High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, 1st Author, 2022 Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex, 11th Author, 2022 Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation, 11th Author, 2022 Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold, 11th Author, 2022 Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis, 11th Author, 2022 Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, 11th Author, 2021 Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells, 11th Author, 2021 Guaianolide sesquiterpene lactones from Achillea millefolium L, 5th Author, 2021 Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide+/ Sirtuin-1 pathway in mice, 11th Author, 2021 Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster, 11th Author, 2021 AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ, 11th Author, 2021 Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection, 11th Author, 2020 Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications, 6th Author, 2020 The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, 11th Author, 2020 Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), 5th Author, 2020 Research Advances of Inner Nuclear Membrane-Associated Degradation, 2nd Author, 2020 Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy, 4th Author, 2020 Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, 0th Author, 2020 The Role of AMPK in Tumorigenesis and Development, 2nd Author, 2020 A fluorogenic probe for tracking GSH flux in developing neurons, 11th Author, 2020 Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, 11th Author, 2020 Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging, 11th Author, 2019 AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., 11th Author, 2018 The Roles of Hepatic Macrophages in-Tissue Homeostasis and Liver Diseases, 2nd Author, 2018 Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents, 4th Author, 2017 Activation and Endocytosis Induced by a 2D Material Agonist., 11th Author, 2017 An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance, 11th Author, 2017 GPCR Activation and Endocytosis Induced by a 2D Material Agonist, 11th Author, 2017 Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: synthesis, characterization and cytotoxicity., Not mentioned, 2017 Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes, 4th Author, 2017 Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking, 11th Author, 2017 53bp1与dna双链断裂损伤修复, 2nd Author, 2016 Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules, 3rd Author, 2016 Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet, 3rd Author, 2016 Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites, 2nd Author, 2016 Development of a novel H2S and GSH detection cocktail for fluorescence imaging, 11th Author, 2016 Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, 11th Author, 2015 Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite, 11th Author, 2015 Probing disease-related proteins with fluorogenic composite materials, 2nd Author, 2015 Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage, 11th Author, 2015 Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe, 2nd Author, 2015 Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Not mentioned, 2015 Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots, Not mentioned

Areas of Focus

Molecular Pharmacology
Traditional Chinese Medicine Pharmacology

Publications

Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells, 11th Author, 2023
Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis, 11th Author, 2023
Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, 11th Author, 2022
Synthesis and Biochemical Evaluation of 8H-Indeno1,2-dthiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors, 11th Author, 2022
A Tandemly Activated Fluorescence Probe for Detecting Senescent Cells with Improved Selectivity by Targeting a Biomarker Combination, 11th Author, 2022
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, 1st Author, 2022
Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex, 11th Author, 2022
Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation, 11th Author, 2022
Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold, 11th Author, 2022
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis, 11th Author, 2022
Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, 11th Author, 2021
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells, 11th Author, 2021
Guaianolide sesquiterpene lactones from Achillea millefolium L, 5th Author, 2021
Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide+/ Sirtuin-1 pathway in mice, 11th Author, 2021
Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster, 11th Author, 2021
AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ, 11th Author, 2021
Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection, 11th Author, 2020
Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications, 6th Author, 2020
The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, 11th Author, 2020
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), 5th Author, 2020
Research Advances of Inner Nuclear Membrane-Associated Degradation, 2nd Author, 2020
Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy, 4th Author, 2020
Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, 0th Author, 2020
The Role of AMPK in Tumorigenesis and Development, 2nd Author, 2020
A fluorogenic probe for tracking GSH flux in developing neurons, 11th Author, 2020
Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, 11th Author, 2020
Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging, 11th Author, 2019
AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., 11th Author, 2018
The Roles of Hepatic Macrophages in-Tissue Homeostasis and Liver Diseases, 2nd Author, 2018
Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents, 4th Author, 2017
Activation and Endocytosis Induced by a 2D Material Agonist., 11th Author, 2017
An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance, 11th Author, 2017
GPCR Activation and Endocytosis Induced by a 2D Material Agonist, 11th Author, 2017
Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: synthesis, characterization and cytotoxicity., Not mentioned, 2017
Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes, 4th Author, 2017
Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking, 11th Author, 2017
53bp1与dna双链断裂损伤修复, 2nd Author, 2016
Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules, 3rd Author, 2016
Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet, 3rd Author, 2016
Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites, 2nd Author, 2016
Development of a novel H2S and GSH detection cocktail for fluorescence imaging, 11th Author, 2016
Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, 11th Author, 2015
Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite, 11th Author, 2015
Probing disease-related proteins with fluorogenic composite materials, 2nd Author, 2015
Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage, 11th Author, 2015
Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe, 2nd Author, 2015
Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Not mentioned, 2015
Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots, Not mentioned

Molecular Pharmacology: Pharmacodynamics Receptor Binding Signal Transduction Drug Metabolism Molecular Biology Cell Biology Biochemistry Pharmacokinetics Drug Discovery Therapeutic Targets Traditional Chinese Medicine Pharmacology: Herbal Medicine Pharmacodynamics Traditional Remedies Bioactive Compounds Therapeutic Effects Clinical Trials Natural Products Integrative Medicine

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