Professor | Jianguo Zhao | Asia Growth Partners

Name	Jianguo Zhao
Contact Information	zhaojg@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

Name

Jianguo Zhao

Contact Information

zhaojg@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Work Experience	2010-08 - Present - Chinese Academy of Sciences, Institute of Zoology - Researcher 2007-07 - 2010-08 - University of Missouri-Columbia - Research Assistant Professor 2005-11 - 2007-06 - University of New Orleans - Postdoc 2003-08 - 2005-11 - Shanghai Jiao Tong University, Institute of Medical Genetics - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Work Experience

2010-08 - Present - Chinese Academy of Sciences, Institute of Zoology - Researcher
2007-07 - 2010-08 - University of Missouri-Columbia - Research Assistant Professor
2005-11 - 2007-06 - University of New Orleans - Postdoc
2003-08 - 2005-11 - Shanghai Jiao Tong University, Institute of Medical Genetics - Assistant Researcher

Areas of Focus	Pig Genome Editing Pig Disease Model Establishment and Functional Gene Research on Economic Traits Molecular Events in Early Embryonic Development of Pigs
Publications	CCDC146 is required for sperm flagellum biogenesis and male fertility in mice, Ma, Yanjie, Wu, Bingbing, Chen, Yinghong, Ma, Shuang, Wang, Liying, Han, Tingting, Lin, Xiaolei, Yang, Fulin, Liu, Chao, Zhao, Jianguo, Li, Wei, 2024 Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0, Zhao, Ying, Chen, Chuanhe, Pan, Jianfei, Lam, Sin Man, Shui, Guanghou, Yang, Shulin, Wu, Tianwen, Yang, Ning, Tao, Cong, Zhao, Jianguo, Wang, Yanfang, 2023 An optimized prime editing system for efficient modification of the pig genome, Qi, Yanan, Zhang, Ying, Tian, Shuangjie, Zong, Ruojun, Yan, Xinghui, Wang, Yu, Wang, Yanfang, Zhao, Jianguo, 2023 Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs, Chuanmin Qiao, Maozhang He, Shumei Wang, Xinjie Jiang, Feng Wang, Xinjian Li, Shuyi Tan, Zhe Chao, Wenshui Xin, Shuai Gao, Jingli Yuan, Qiang Li, Zichun Xu, Xinli Zheng, Jianguo Zhao, Guangliang Liu, 2023 遗传修饰猪模型在生物医学及农业领域研究进展及应用, 高菲, 王煜, 杜嘉祥, 杜旭光, 赵建国, 2023 Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells, Liu, Wenwen, Chen, Min, Liu, Chao, Wang, Liying, Wei, Huafang, Zhang, Ruidan, Ren, Zhengxing, Chen, Yinghong, Luo, Mengcheng, Zhao, Jianguo, Jiang, Hongwei, Gao, Fei, Li, Wei, 2023 One-step base editing in multiple genes by direct embryo injection for pig trait improvement, 赵建国, 2022 Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells, Liu, Wenwen, Chen, Min, Liu, Chao, Wang, Liying, Wei, Huafang, Zhang, Ruidan, Ren, Zhengxing, Chen, Yinghong, Luo, Mengcheng, Zhao, Jianguo, Jiang, Hongwei, Gao, Fei, Li, Wei, 2022 CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model, Yao, Jing, Wang, Yu, Cao, Chunwei, Song, Ruigao, Bi, Dengfeng, Zhang, Hongyong, Li, Yongshun, Qin, Guosong, Hou, Naipeng, Zhang, Nan, Zhang, Jin, Guo, Weiwei, Yang, Shiming, Wang, Yanfang, Zhao, Jianguo, 2021 家族性反常性痤疮猪模型的创制及其致病机理的研究, 宋瑞高, 刘克强, 王煜, 秦国嵩, 肖萌, 刘雅萍, 杨俊, 宗若君, 闫星彗, 郑千涛, 张洪勇, 侯乃鹏, 姚婧, 王霄, 王彦芳, 赵建国, 张学, 2021 CRISPR/Cas13d-mediated efficient KDM5B mRNA knockdown in porcine somatic cells and parthenogenetic embryos, Bi, Dengfeng, Yao, Jing, Wang, Yu, Qin, Guosong, Zhang, Yunting, Wang, Yanfang, Zhao, Jianguo, 2021 A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway, Song, Ruigao, Liu, Keqiang, Wang, Yu, Qin, Guosong, Xiao, Meng, Liu, Yaping, Yang, Jun, Zong, Ruojun, Yan, Xinghui, Zheng, Qiantao, Zhang, Hongyong, Hou, Naipeng, Yao, Jing, Wang, Xiao, Wang, Yanfang, Zhao, Jianguo, Zhang, Xue, 2021 Mitochondrial Uncoupling Protein-1 Antagonizes Atherosclerosis by Blocking NLRP3-Inflammasome-dependent Interleukin-1β production, 赵建国, 2021 CRISPR/Cas13d介导猪胎儿成纤维细胞SUV39H1/SUV39H2基因敲降, 毕登峰, 王煜, 姚婧, 赵建国, 2021 Cytosine Base Editor (hA3A-BE3-NG)-Mediated Multiple Gene Editing for Pyramid Breeding in Pigs, Wang, Yu, Bi, Dengfeng, Qin, Guosong, Song, Ruigao, Yao, Jing, Cao, Chunwei, Zheng, Qiantao, Hou, Naipeng, Wang, Yanfang, Zhao, Jianguo, 2020 The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos, Li, Feifei, Wang, Danyang, Song, Ruigao, Cao, Chunwei, Zhang, Zhihua, Wang, Yu, Li, Xiaoli, Huang, Jiaojiao, Liu, Qiang, Hou, Naipeng, Xu, Bingxiang, Li, Xiao, Gao, Xiaomeng, Jia, Yan, Zhao, Jianguo, Wang, Yanfang, 2020 Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis, 赵建国, 2020 碱基编辑器介导的猪IGF2基因高效定点突变, 王煜, 宋瑞高, 赵建国, 王彦芳, 2020 Base editing in pigs for precision breeding, Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO, 2020 Stearoyl-CoA Desaturase Is Essential for Porcine Adipocyte Differentiation, Liu, Lulu, Wang, Yu, Liang, Xiaojuan, Wu, Xiao, Liu, Jiali, Yang, Shulin, Tao, Cong, Zhang, Jin, Tian, Jianhui, Zhao, Jianguo, Wang, Yanfang, 2020 急性冷刺激后巴马猪背膘和腹股沟皮下脂肪组织的脂质组比较, 潘建飞, 郑千涛, 陶聪, 赵建国, 王彦芳, 2020 beta-Selective Cu(II)-Catalyzed Dehydrogenative Enamination of Alkylbenzenes, Zhao, JianGuo, Wang, DongHui, 2020 Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs, Jianfei Pan, Cong Tao, Chunwei Cao, Qiantao Zheng, Sin Man Lam, Guanghou Shui, Xuexue Liu, Kui Li, Jianguo Zhao, Yanfang Wang, 2019 Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs, Pan, Jianfei, Tao, Cong, Cao, Chunwei, Zheng, Qiantao, Lam, Sin Man, Shui, Guanghou, Liu, Xuexue, Li, Kui, Zhao, Jianguo, Wang, Yanfang, 2019 Genome editing in large animals:current status and future prospects, Jianguo Zhao, Liangxue Lai, Weizhi Ji, Qi Zhou, 2019 A novel porcine model reproduces human oculocutaneous albinism type, Zhang, Ying, Hong, Qianlong, Cao, Chunwei, Yang, Lizhu, Li, Yongshun, Hai, Tang, Zhang, Hongyong, Zhou, Qi, Sui, Ruifang, Zhao, Jianguo, 2019 Adipocyte-specific disruption of ATPase copper transporting alpha in mice accelerates lipoatrophy, Tao, Cong, Wang, Yajun, Zhao, Ying, Pan, Jianfei, Fan, Yiping, Liang, Xiaojuan, Cao, Chunwei, Zhao, Jianguo, Petris, Michael J, Li, Kui, Wang, Yanfang, 2019 MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland, Qiu, Jingtao, Zhang, Jinglin, Zhou, Yewen, Li, Xin, Li, Hongjiao, Liu, Jiali, Gou, Kemian, Zhao, Jianguo, Cui, Sheng, 2019 Canalostomy is an ideal surgery route for inner ear gene delivery in big animal model, Ji, XiaoJun, Chen, Wei, Wang, Xiao, Zhang, Yue, Liu, Qian, Guo, WeiWei, Zhao, JianGuo, Yang, ShiMing, 2019 A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment, Wang, Xiao, Cao, Chunwei, Li, Yongshun, Hai, Tang, Jia, Qitao, Zhang, Ying, Zheng, Qiantao, Yao, Jing, Qin, Guosong, Zhang, Hongyong, Song, Ruigao, Wang, Yanfang, Shui, Guanghou, Lam, Sin Man, Liu, Zhonghua, Wei, Hong, Meng, Anming, Zhou, Qi, Zhao, Jianguo, 2019 猪PRLR和FSHβ基因多态性检测及其与繁殖性状的关联分析, 范一萍, 王晓梅, 贾启涛, 李成勃, 梁小娟, 曹春伟, 周磊, 陶聪, 赵建国, 刘剑锋, 王彦芳

Areas of Focus

Pig Genome Editing
Pig Disease Model Establishment and Functional Gene Research on Economic Traits
Molecular Events in Early Embryonic Development of Pigs

Publications

CCDC146 is required for sperm flagellum biogenesis and male fertility in mice, Ma, Yanjie, Wu, Bingbing, Chen, Yinghong, Ma, Shuang, Wang, Liying, Han, Tingting, Lin, Xiaolei, Yang, Fulin, Liu, Chao, Zhao, Jianguo, Li, Wei, 2024
Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0, Zhao, Ying, Chen, Chuanhe, Pan, Jianfei, Lam, Sin Man, Shui, Guanghou, Yang, Shulin, Wu, Tianwen, Yang, Ning, Tao, Cong, Zhao, Jianguo, Wang, Yanfang, 2023
An optimized prime editing system for efficient modification of the pig genome, Qi, Yanan, Zhang, Ying, Tian, Shuangjie, Zong, Ruojun, Yan, Xinghui, Wang, Yu, Wang, Yanfang, Zhao, Jianguo, 2023
Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs, Chuanmin Qiao, Maozhang He, Shumei Wang, Xinjie Jiang, Feng Wang, Xinjian Li, Shuyi Tan, Zhe Chao, Wenshui Xin, Shuai Gao, Jingli Yuan, Qiang Li, Zichun Xu, Xinli Zheng, Jianguo Zhao, Guangliang Liu, 2023
遗传修饰猪模型在生物医学及农业领域研究进展及应用, 高菲, 王煜, 杜嘉祥, 杜旭光, 赵建国, 2023
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells, Liu, Wenwen, Chen, Min, Liu, Chao, Wang, Liying, Wei, Huafang, Zhang, Ruidan, Ren, Zhengxing, Chen, Yinghong, Luo, Mengcheng, Zhao, Jianguo, Jiang, Hongwei, Gao, Fei, Li, Wei, 2023
One-step base editing in multiple genes by direct embryo injection for pig trait improvement, 赵建国, 2022
Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells, Liu, Wenwen, Chen, Min, Liu, Chao, Wang, Liying, Wei, Huafang, Zhang, Ruidan, Ren, Zhengxing, Chen, Yinghong, Luo, Mengcheng, Zhao, Jianguo, Jiang, Hongwei, Gao, Fei, Li, Wei, 2022
CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model, Yao, Jing, Wang, Yu, Cao, Chunwei, Song, Ruigao, Bi, Dengfeng, Zhang, Hongyong, Li, Yongshun, Qin, Guosong, Hou, Naipeng, Zhang, Nan, Zhang, Jin, Guo, Weiwei, Yang, Shiming, Wang, Yanfang, Zhao, Jianguo, 2021
家族性反常性痤疮猪模型的创制及其致病机理的研究, 宋瑞高, 刘克强, 王煜, 秦国嵩, 肖萌, 刘雅萍, 杨俊, 宗若君, 闫星彗, 郑千涛, 张洪勇, 侯乃鹏, 姚婧, 王霄, 王彦芳, 赵建国, 张学, 2021
CRISPR/Cas13d-mediated efficient KDM5B mRNA knockdown in porcine somatic cells and parthenogenetic embryos, Bi, Dengfeng, Yao, Jing, Wang, Yu, Qin, Guosong, Zhang, Yunting, Wang, Yanfang, Zhao, Jianguo, 2021
A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway, Song, Ruigao, Liu, Keqiang, Wang, Yu, Qin, Guosong, Xiao, Meng, Liu, Yaping, Yang, Jun, Zong, Ruojun, Yan, Xinghui, Zheng, Qiantao, Zhang, Hongyong, Hou, Naipeng, Yao, Jing, Wang, Xiao, Wang, Yanfang, Zhao, Jianguo, Zhang, Xue, 2021
Mitochondrial Uncoupling Protein-1 Antagonizes Atherosclerosis by Blocking NLRP3-Inflammasome-dependent Interleukin-1β production, 赵建国, 2021
CRISPR/Cas13d介导猪胎儿成纤维细胞SUV39H1/SUV39H2基因敲降, 毕登峰, 王煜, 姚婧, 赵建国, 2021
Cytosine Base Editor (hA3A-BE3-NG)-Mediated Multiple Gene Editing for Pyramid Breeding in Pigs, Wang, Yu, Bi, Dengfeng, Qin, Guosong, Song, Ruigao, Yao, Jing, Cao, Chunwei, Zheng, Qiantao, Hou, Naipeng, Wang, Yanfang, Zhao, Jianguo, 2020
The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos, Li, Feifei, Wang, Danyang, Song, Ruigao, Cao, Chunwei, Zhang, Zhihua, Wang, Yu, Li, Xiaoli, Huang, Jiaojiao, Liu, Qiang, Hou, Naipeng, Xu, Bingxiang, Li, Xiao, Gao, Xiaomeng, Jia, Yan, Zhao, Jianguo, Wang, Yanfang, 2020
Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis, 赵建国, 2020
碱基编辑器介导的猪IGF2基因高效定点突变, 王煜, 宋瑞高, 赵建国, 王彦芳, 2020
Base editing in pigs for precision breeding, Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO, 2020
Stearoyl-CoA Desaturase Is Essential for Porcine Adipocyte Differentiation, Liu, Lulu, Wang, Yu, Liang, Xiaojuan, Wu, Xiao, Liu, Jiali, Yang, Shulin, Tao, Cong, Zhang, Jin, Tian, Jianhui, Zhao, Jianguo, Wang, Yanfang, 2020
急性冷刺激后巴马猪背膘和腹股沟皮下脂肪组织的脂质组比较, 潘建飞, 郑千涛, 陶聪, 赵建国, 王彦芳, 2020
beta-Selective Cu(II)-Catalyzed Dehydrogenative Enamination of Alkylbenzenes, Zhao, JianGuo, Wang, DongHui, 2020
Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs, Jianfei Pan, Cong Tao, Chunwei Cao, Qiantao Zheng, Sin Man Lam, Guanghou Shui, Xuexue Liu, Kui Li, Jianguo Zhao, Yanfang Wang, 2019
Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs, Pan, Jianfei, Tao, Cong, Cao, Chunwei, Zheng, Qiantao, Lam, Sin Man, Shui, Guanghou, Liu, Xuexue, Li, Kui, Zhao, Jianguo, Wang, Yanfang, 2019
Genome editing in large animals:current status and future prospects, Jianguo Zhao, Liangxue Lai, Weizhi Ji, Qi Zhou, 2019
A novel porcine model reproduces human oculocutaneous albinism type, Zhang, Ying, Hong, Qianlong, Cao, Chunwei, Yang, Lizhu, Li, Yongshun, Hai, Tang, Zhang, Hongyong, Zhou, Qi, Sui, Ruifang, Zhao, Jianguo, 2019
Adipocyte-specific disruption of ATPase copper transporting alpha in mice accelerates lipoatrophy, Tao, Cong, Wang, Yajun, Zhao, Ying, Pan, Jianfei, Fan, Yiping, Liang, Xiaojuan, Cao, Chunwei, Zhao, Jianguo, Petris, Michael J, Li, Kui, Wang, Yanfang, 2019
MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland, Qiu, Jingtao, Zhang, Jinglin, Zhou, Yewen, Li, Xin, Li, Hongjiao, Liu, Jiali, Gou, Kemian, Zhao, Jianguo, Cui, Sheng, 2019
Canalostomy is an ideal surgery route for inner ear gene delivery in big animal model, Ji, XiaoJun, Chen, Wei, Wang, Xiao, Zhang, Yue, Liu, Qian, Guo, WeiWei, Zhao, JianGuo, Yang, ShiMing, 2019
A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment, Wang, Xiao, Cao, Chunwei, Li, Yongshun, Hai, Tang, Jia, Qitao, Zhang, Ying, Zheng, Qiantao, Yao, Jing, Qin, Guosong, Zhang, Hongyong, Song, Ruigao, Wang, Yanfang, Shui, Guanghou, Lam, Sin Man, Liu, Zhonghua, Wei, Hong, Meng, Anming, Zhou, Qi, Zhao, Jianguo, 2019
猪PRLR和FSHβ基因多态性检测及其与繁殖性状的关联分析, 范一萍, 王晓梅, 贾启涛, 李成勃, 梁小娟, 曹春伟, 周磊, 陶聪, 赵建国, 刘剑锋, 王彦芳

Crispr/Cas9 Gene Knockout Transgenic Pigs Disease Models Biomedical Research Preclinical Translation Histone Deacetylase Inhibitors Zinc Finger Nucleases Genome Editing Embryonic Development

Jianguo Zhao - University of Chinese Academy of Sciences

Han Zhiming - University of Chinese Academy of Sciences

Hui Yang - University of Chinese Academy of Sciences

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