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Yingtong Di
Medical School
University of Chinese Academy of Sciences
Yunnan
Language: Chinese, English
Contact
Natural Products Chemical Biology Biosynthesis Enzyme Catalysis Fungal Metabolites Drug Discovery Target Binding Synthetic Biology Biochemistry Genetic Engineering
Areas of Focus
  • Chemical Biology of Natural Products
  • Biosynthesis Pathways and Enzyme Catalysis Mechanisms of Fungal Active Secondary Metabolites
  • Discovery of New Target/Drug Binding Sites in Natural Products
  • Synthetic Biology of Active Natural Products
Work Experience
  • 2022-01~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Principal Investigator
  • 2019-01~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Doctoral Supervisor
  • 2016-01~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
  • 2009-01~2015-12 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
  • 2007-04~2008-12 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher
  • 2003-07~2003-12 - Key Laboratory of Natural Products, Guizhou Province, Chinese Academy of Sciences - Research Intern
  • 1996-07~2000-08 - Taiyuan Ruifeng Pharmaceutical Co., Ltd. - Business Development Manager
Academic Background & Achievements
  • 2011-04--2012-04 Visiting Scholar: University of California, Los Angeles
  • 2004-03--2007-03 Ph.D. in Science: Kunming Institute of Botany, Chinese Academy of Sciences
  • 2000-09--2003-07 M.Sc. in Science: Chengdu Institute of Biology, Chinese Academy of Sciences
  • 1992-09--1996-06 B.Sc. in Biology: Lanzhou University
Publications
  • Pepluenone, a new pepluane-type diterpenoid with inhibitory activity on the release of NO from the whole plant of Euphorbia peplus L., Yingtong Di, 2023
  • Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy, Yingtong Di, 2023
  • Euphpepluone S, a new lathyrane diterpenoid with anti-inflammatory activity from Euphorbia peplus L., Yingtong Di, 2023
  • Inverse Electron-Demanding Diels-Alder Reactions in the Chemical Synthesis of Prenylated Indole Alkaloids Containing a Bicycle2.2.2diazaoctane Moiety: A Theoretical Study, Yingtong Di, 2023
  • Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway, Yingtong Di, 2023
  • Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology, Yingtong Di, 2023
  • Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect, Yingtong Di, 2023
  • Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux, Yingtong Di, 2022
  • Jatrophane polyesters from the leaves of Euphorbia peplus with anti-inflammatory activity, Yingtong Di, 2022
  • New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch., Yingtong Di, 2021
  • Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway, Yingtong Di, 2021
  • Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr., Yingtong Di, 2021
  • Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L., Yingtong Di, 2020
  • 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata, Yingtong Di, 2019
  • Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings, Yingtong Di, 2019
  • Irpexlacte A-D, four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense, Yingtong Di, 2019
  • Abietane Diterpernoids from the Roots of Euphorbia ebracteolata, Yingtong Di, 2018
  • Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus, Yingtong Di, 2018
  • Munronin O, a potential activator for plant resistance, Yingtong Di, 2018
  • Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT, Yingtong Di, 2018
  • Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum, Yingtong Di, 2018
  • Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis, Yingtong Di, 2018
  • Daphniphyllum alkaloids with cytotoxic activity from Daphniphyllum angustifolium, Yingtong Di, 2018
  • Chemical constituents from Boletus luridus, Yingtong Di, 2018
  • Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata, Yingtong Di, 2017
  • Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A, Yingtong Di, 2017
  • 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors, Yingtong Di, 2016
  • Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora, Yingtong Di, 2016
  • Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton, Yingtong Di, 2016
  • Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata, Yingtong Di, 2016
  • Protein kinase C controls lysosome biogenesis independently of mTORC1, Yingtong Di, 2016
  • New Compounds from the Roots and Stems of Trigonostemonlii and Their Cytotoxic Activities, Yingtong Di, 2016
  • Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum, Yingtong Di, 2016
  • Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone, Yingtong Di, 2016
  • Speramides A-B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007, Yingtong Di, 2016
  • Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth, Yingtong Di
Awards
  • Plant Chemical Defense Substances and New Pesticide Lead Compounds Research (2013): First Prize, Provincial Level
  • Research on Novel Structure Alkaloids in Tiger Skin (2009): First Prize, Provincial Level
  • Excellent Award of the President of the Chinese Academy of Sciences (2007)
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