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Guiquan Chen
Medical School
Nanjing University
Jiangsu
Language: English, Chinese
Neural Stem Cells
Glial Precursor Cells
Molecular Mechanisms
Neurodegeneration
Alzheimer'S Disease
Drug Screening
Cell Biology
Genetics
Neuroscience
Disease Mechanisms
Areas of Focus
- Molecular mechanisms of neural stem cell and glial precursor cell fate determination
- Molecular mechanisms of neurodegenerative death
- Research on the screening and mechanism of action of AD drugs
Academic Background & Achievements
- 2005 - PhD in Neuroscience: University of Edinburgh
- Research on mechanisms of diseases related to the nervous system
Publications
- Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but not into basal progenitors in the developing hippocampus, Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji M, Chen G, 2022
- A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice, Teng X, Hu P, Chen Y, Zang Y, Ye X, Ou J, Chen G, Shi YS, 2022
- Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1, Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y, Chen G, 2021
- Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system, Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G, 2021
- Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system, Wang H, Liu M, Zou G, Wang L, Duan W, He X, Ji M, Zou X, Hu Y, Yang J, Chen G, 2021
- Neuron-specific deletion of presenilin enhancer 2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling, Bi H, Zhou C, Zhang Y, Cai X, Ji M, Yang J, Chen G, Hu Y, 2021
- In vivo brain imaging of amyloid-β aggregates in Alzheimer's disease with a near-infrared fluorescent probe, Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B, Chen G, Liu H-K, Qian Y, 2021
- Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury, Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G, Gu X, 2021
- Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis, Shao C, Yuan J, Liu Y, Wang X, Gu J, Chen G, Zhang B, Liu H, Zhao J, Zhu H, Qian Y, 2020
- Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development, Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z, Hu Y, 2020
- Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease, Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G, Guo Z, Wang X, 2020
- Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors, Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J, Chen G, 2019
