Professor | Guiquan Chen | Asia Growth Partners

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Name	Guiquan Chen
Contact Information	chenguiquan@nju.edu.cn
Language ability	English, Chinese
Province	Jiangsu

Upload Avatar (500 x 500)

Name

Guiquan Chen

Contact Information

chenguiquan@nju.edu.cn

Language ability

English, Chinese

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Medical School
Academic Background & Achievements	2005 - PhD in Neuroscience: University of Edinburgh Research on mechanisms of diseases related to the nervous system

University/Lab Affiliation and Title

Nanjing University

Faculty

Medical School

Academic Background & Achievements

2005 - PhD in Neuroscience: University of Edinburgh
Research on mechanisms of diseases related to the nervous system

Areas of Focus	Molecular mechanisms of neural stem cell and glial precursor cell fate determination Molecular mechanisms of neurodegenerative death Research on the screening and mechanism of action of AD drugs
Publications	Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but not into basal progenitors in the developing hippocampus, Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji M, Chen G, 2022 A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice, Teng X, Hu P, Chen Y, Zang Y, Ye X, Ou J, Chen G, Shi YS, 2022 Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1, Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y, Chen G, 2021 Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system, Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G, 2021 Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system, Wang H, Liu M, Zou G, Wang L, Duan W, He X, Ji M, Zou X, Hu Y, Yang J, Chen G, 2021 Neuron-specific deletion of presenilin enhancer 2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling, Bi H, Zhou C, Zhang Y, Cai X, Ji M, Yang J, Chen G, Hu Y, 2021 In vivo brain imaging of amyloid-β aggregates in Alzheimer's disease with a near-infrared fluorescent probe, Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B, Chen G, Liu H-K, Qian Y, 2021 Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury, Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G, Gu X, 2021 Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis, Shao C, Yuan J, Liu Y, Wang X, Gu J, Chen G, Zhang B, Liu H, Zhao J, Zhu H, Qian Y, 2020 Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development, Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z, Hu Y, 2020 Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease, Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G, Guo Z, Wang X, 2020 Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors, Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J, Chen G, 2019

Areas of Focus

Molecular mechanisms of neural stem cell and glial precursor cell fate determination
Molecular mechanisms of neurodegenerative death
Research on the screening and mechanism of action of AD drugs

Publications

Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but not into basal progenitors in the developing hippocampus, Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji M, Chen G, 2022
A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice, Teng X, Hu P, Chen Y, Zang Y, Ye X, Ou J, Chen G, Shi YS, 2022
Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1, Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y, Chen G, 2021
Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system, Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G, 2021
Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system, Wang H, Liu M, Zou G, Wang L, Duan W, He X, Ji M, Zou X, Hu Y, Yang J, Chen G, 2021
Neuron-specific deletion of presenilin enhancer 2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling, Bi H, Zhou C, Zhang Y, Cai X, Ji M, Yang J, Chen G, Hu Y, 2021
In vivo brain imaging of amyloid-β aggregates in Alzheimer's disease with a near-infrared fluorescent probe, Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B, Chen G, Liu H-K, Qian Y, 2021
Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury, Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G, Gu X, 2021
Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis, Shao C, Yuan J, Liu Y, Wang X, Gu J, Chen G, Zhang B, Liu H, Zhao J, Zhu H, Qian Y, 2020
Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development, Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z, Hu Y, 2020
Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease, Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G, Guo Z, Wang X, 2020
Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors, Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J, Chen G, 2019

Neural Stem Cells Glial Precursor Cells Molecular Mechanisms Neurodegeneration Alzheimer'S Disease Drug Screening Cell Biology Genetics Neuroscience Disease Mechanisms

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