Professor | Zhang Jiamin | Asia Growth Partners

Name	Zhang Jiamin
Contact Information	zhangjiamin@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Zhang Jiamin

Contact Information

zhangjiamin@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2004.09-2008.07 Bachelor of Agriculture, China Agricultural University 2008.09-2013.07 PhD in Biochemistry and Molecular Biology, Peking Union Medical College/Beijing Institute of Life Sciences 2020 Selected for Shanghai Overseas High-Level Talent Introduction Plan 2021 Received funding from the National Natural Science Foundation of China (Overseas)
Work Experience	2021.04-present, Tongji University School of Life Sciences and Technology/Tongji University Advanced Research Institute, Distinguished Researcher 2021.01-present, Tongji University Affiliated Tongji Hospital, Distinguished Researcher 2015.10-2020.10, Massachusetts General Hospital Cancer Center/Harvard Medical School, Postdoctoral Researcher 2013.07-2015.10, Beijing Institute of Life Sciences, Research Assistant

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2004.09-2008.07 Bachelor of Agriculture, China Agricultural University
2008.09-2013.07 PhD in Biochemistry and Molecular Biology, Peking Union Medical College/Beijing Institute of Life Sciences
2020 Selected for Shanghai Overseas High-Level Talent Introduction Plan
2021 Received funding from the National Natural Science Foundation of China (Overseas)

Work Experience

2021.04-present, Tongji University School of Life Sciences and Technology/Tongji University Advanced Research Institute, Distinguished Researcher
2021.01-present, Tongji University Affiliated Tongji Hospital, Distinguished Researcher
2015.10-2020.10, Massachusetts General Hospital Cancer Center/Harvard Medical School, Postdoctoral Researcher
2013.07-2015.10, Beijing Institute of Life Sciences, Research Assistant

Areas of Focus	Telomere maintenance and DNA damage repair Molecular mechanisms of genome stability maintenance Development of new strategies for targeted cancer therapy
Publications	Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022 RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021 Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021 Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019 cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020 Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020 CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020 Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020 ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020 Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014

Areas of Focus

Telomere maintenance and DNA damage repair
Molecular mechanisms of genome stability maintenance
Development of new strategies for targeted cancer therapy

Publications

Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021
Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019
cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020
Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014

Telomere Dna Repair Genome Stability Cancer Therapy Molecular Mechanisms Targeted Therapy Alt Pathway Biomedical Research Genetic Variation Therapeutic Strategies

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