Areas of Focus
- Telomere maintenance and DNA damage repair
- Molecular mechanisms of genome stability maintenance
- Development of new strategies for targeted cancer therapy
Work Experience
- 2021.04-present, Tongji University School of Life Sciences and Technology/Tongji University Advanced Research Institute, Distinguished Researcher
- 2021.01-present, Tongji University Affiliated Tongji Hospital, Distinguished Researcher
- 2015.10-2020.10, Massachusetts General Hospital Cancer Center/Harvard Medical School, Postdoctoral Researcher
- 2013.07-2015.10, Beijing Institute of Life Sciences, Research Assistant
Academic Background & Achievements
- 2004.09-2008.07 Bachelor of Agriculture, China Agricultural University
- 2008.09-2013.07 PhD in Biochemistry and Molecular Biology, Peking Union Medical College/Beijing Institute of Life Sciences
- 2020 Selected for Shanghai Overseas High-Level Talent Introduction Plan
- 2021 Received funding from the National Natural Science Foundation of China (Overseas)
Publications
- Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
- RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021
- Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021
- Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019
- cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
- CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
- ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
- Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014
