Areas of Focus
- 端粒维持和DNA损伤修复
- 基因组稳定性维持的分子机制
- 开发肿瘤靶向治疗的新策略
Work Experience
- 2021.04-至今，同济大学生命科学与技术学院/同济大学高等研究院，特聘研究员
- 2021.01-至今，同济大学附属同济医院，特聘研究员
- 2015.10-2020.10，麻省总医院癌症中心/哈佛医学院，博士后
- 2013.07-2015.10，北京生命科学研究所，科研助理
Academic Background & Achievements
- 2004.09-2008.07 中国农业大学，农学学士
- 2008.09-2013.07 北京协和医学院/北京生命科学研究所，生物化学与分子生物学博士
- 2020 年入选上海市海外高层次人才引进计划
- 2021 年获得国家自然科学基金优秀青年科学基金项目（海外）资助
Publications
- Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
- RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021
- Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021
- Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019
- cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
- CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
- ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
- Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014
