Professor | 张家民 | 数字化转型顾问

Name	张家民
Contact Information	zhangjiamin@tongji.edu.cn
Language ability	中文, 英语
Province	上海

Name

张家民

Contact Information

zhangjiamin@tongji.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	同济大学
Faculty	Life Sciences
Academic Background & Achievements	2004.09-2008.07 中国农业大学，农学学士 2008.09-2013.07 北京协和医学院/北京生命科学研究所，生物化学与分子生物学博士 2020 年入选上海市海外高层次人才引进计划 2021 年获得国家自然科学基金优秀青年科学基金项目（海外）资助
Work Experience	2021.04-至今，同济大学生命科学与技术学院/同济大学高等研究院，特聘研究员 2021.01-至今，同济大学附属同济医院，特聘研究员 2015.10-2020.10，麻省总医院癌症中心/哈佛医学院，博士后 2013.07-2015.10，北京生命科学研究所，科研助理

University/Lab Affiliation and Title

同济大学

Faculty

Life Sciences

Academic Background & Achievements

2004.09-2008.07 中国农业大学，农学学士
2008.09-2013.07 北京协和医学院/北京生命科学研究所，生物化学与分子生物学博士
2020 年入选上海市海外高层次人才引进计划
2021 年获得国家自然科学基金优秀青年科学基金项目（海外）资助

Work Experience

2021.04-至今，同济大学生命科学与技术学院/同济大学高等研究院，特聘研究员
2021.01-至今，同济大学附属同济医院，特聘研究员
2015.10-2020.10，麻省总医院癌症中心/哈佛医学院，博士后
2013.07-2015.10，北京生命科学研究所，科研助理

Areas of Focus	端粒维持和DNA损伤修复基因组稳定性维持的分子机制开发肿瘤靶向治疗的新策略
Publications	Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022 RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021 Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021 Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019 cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020 Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020 CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020 Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020 ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020 Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014

Areas of Focus

端粒维持和DNA损伤修复
基因组稳定性维持的分子机制
开发肿瘤靶向治疗的新策略

Publications

Protocol to Stimulate and Delineate Alternative Lengthening of Telomeres (ALT) in Human U2OS Cells, Zhang, J.M., Zou, L., 2022
RNA transcripts stimulate homologous recombination by forming DR-loops, Ouyang, J., Yadav, T., Zhang, J.M., Yang, H., Rheinbay, E., Guo, H., Haber, D.A., Lan, L., and Zou, L., 2021
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies, Zhang, J.M., Genois, M.M., Ouyang, J., Lan, L., and Zou, L., 2021
Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways, Zhang, J.M., Yadav, T., Ouyang, J., Lan, L., and Zou, L., 2019
cGAS suppresses genomic instability as a decelerator of replication forks, Chen, H., Chen, H., Zhang, J.M., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., Lan L., 2020
Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells, Shin, S.H., Lee, J.S., Zhang, J.M., Choi, S., Boskovic, Z.V., Zhao, R., Song, M., Wang, R., Tian, J., Lee, M.H., et al., 2020
CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation, Zhang, J.M., Zheng, J.X., Ding, Y.H., Zhang, X.R., Suo, F., Ren, J.Y., Dong, M.Q., and Du, L.L., 2020
Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks, Zhang, J.M., and Zou, L., 2020
ATR protects the genome against R loops through a MUS81-triggered feedback loop, Matos, D.A., Zhang, J.M., Ouyang, J., Nguyen, H.D., Genois, M.M. and Zou, L., 2020
Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2, Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., et al., 2014

端粒 Dna修复基因组稳定性癌症治疗分子机制靶向治疗 Alt通路生物医学研究基因变异治疗策略

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