Professor | 陈御 | 数字化转型顾问

Name	陈御
Contact Information	y_chen@tongji.edu.cn
Language ability	中文, 英语
Province	上海

Name

陈御

Contact Information

y_chen@tongji.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	同济大学
Faculty	Life Sciences
Academic Background & Achievements	博士学位主持国家青年项目和上海市科技项目在高影响力期刊上以第一作者和通讯作者身份发表文章
Work Experience	2023年至今 - 同济大学 - 助理教授，硕士生导师 2022年至2023年 - 同济大学附属医院 - 助理研究员 2021年至2022年 - 同济大学附属医院 - 研究实习员
Awards	2023年 - 全国青年优秀生理学学术汇报最佳表达奖 2022年 - 上海市医学科技奖 2021年 - 同济大学追求卓越奖 2022年 - 同济大学优秀博士论文

University/Lab Affiliation and Title

同济大学

Faculty

Life Sciences

Academic Background & Achievements

博士学位
主持国家青年项目和上海市科技项目
在高影响力期刊上以第一作者和通讯作者身份发表文章

Work Experience

2023年至今 - 同济大学 - 助理教授，硕士生导师
2022年至2023年 - 同济大学附属医院 - 助理研究员
2021年至2022年 - 同济大学附属医院 - 研究实习员

Awards

2023年 - 全国青年优秀生理学学术汇报最佳表达奖
2022年 - 上海市医学科技奖
2021年 - 同济大学追求卓越奖
2022年 - 同济大学优秀博士论文

Areas of Focus	衰老与基因组稳定性 DNA修复及衰老机制抗衰老及相关疾病策略的开发
Publications	Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023 Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023 Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023 Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024 A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019 IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023 The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020 A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020 Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020 Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018 DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022 The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022 Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y

Areas of Focus

衰老与基因组稳定性
DNA修复及衰老机制
抗衰老及相关疾病策略的开发

Publications

Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019
IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023
The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022
The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022
Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y

衰老基因组稳定性 Dna修复长寿基因调控表观遗传学健康寿命抗衰老疾病干预生物医学研究

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