Areas of Focus
- Aging and genomic stability
- Mechanisms of DNA repair and aging
- Development of anti-aging and related disease strategies
Work Experience
- 2023-Present - Tongji University - Assistant Professor, Master's Supervisor
- 2022-2023 - Tongji University Affiliated Hospital - Assistant Researcher
- 2021-2022 - Tongji University Affiliated Hospital - Research Intern
Academic Background & Achievements
- PhD degree
- Hosts national youth projects and Shanghai science and technology projects
- Published as first and corresponding author in high-impact journals
Publications
- Impaired end joining induces cardiac atrophy in a Hutchinson-Gilford progeria mouse model, Chen Y, Huang S, Cui Z, Sun X, Tang Y, Zhang H, Chen Z, Jiang R, Zhang W, Li X, Chen J, Liu B, Jiang Y, Wei K, Mao Z, 2023
- Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription, Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y, Mao Z, 2023
- Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation, Zhen Z, Chen Y, Wang H, Tang H, Zhang H, Liu H, Jiang Y, Mao Z, 2023
- Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence, Chen Y, Xu X, Chen Z, Chen L, Jiang Y, Mao Z, 2024
- A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z, 2019
- IDDoR: a novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways, Chen Y, Cui Z, Chen Z, Jiang Y, Mao Z, 2023
- The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells, Chen Y, Chen J, Sun X, Yu J, Qian Z, Wu L, Xu X, Wan X, Jiang Y, Zhang J, Gao S, Mao Z, 2020
- A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing, Zhang W, Chen Y, Yang J, Zhang J, Yu J, Wang M, Zhao X, Wei K, Wan X, Xu X, Jiang Y, Chen J, Gao S, Mao Z, 2020
- Fight to the bitter end: DNA repair and aging, Chen Y, Geng A, Zhang W, Qian Z, Wan X, Jiang Y, Mao Z, 2020
- Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y, Mao Z, 2018
- DNA double-strand break repair and nucleic acid-related immunity, Zhang H, Chen Y, Jiang Y, Mao Z, 2022
- The landscape of aging, Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang C, Ying Y, Dou X, Chen Y, Xiao F, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong Q, Liu Q, Zou W, Tian X, Xiao Z, Liu Y, Liu J, Song M, Han J, Liu GH, 2022
- Biomarkers of aging, Aging Biomarker Consortium; Bao H, Cao J, Chen M, Chen M, Chen W, Chen X, Chen Y, Chen Y, Chen Y, Chen Z, Chhetri JK, Ding Y, Feng J, Guo J, Guo M, He C, Jia Y, Jiang H, Jing Y, Li D, Li J, Li J, Liang Q, Liang R, Liu F, Liu X, Liu Z, Luo O, Lv J, Ma J, Mao K, Nie J, Qiao X, Sun X, Tang X, Wang J, Wang Q, Wang S, Wang X, Wang Y, Wang Y, Wu R, Xia K, Xiao F, Xu L, Xu Y, Yan H, Yang L, Yang R, Yang Y, Ying Y, Zhang L, Zhang W, Zhang W, Zhang X, Zhang Z, Zhou M, Zhou R, Zhu Q, Zhu Z, Cao F, Cao Z, Chan P, Chen C, Chen G, Chen H, Chen J, Ci W, Ding B, Ding Q, Gao F, Han J, Huang K, Ju Z, Kong Q, Li J, Li J, Li X, Liu B, Liu F, Liu L, Liu Q, Liu Q, Liu X, Liu Y, Luo X, Ma S, Ma X, Mao Z, Nie J, Peng Y, Qu J, Ren J, Ren R, Song M, Songyang Z, Sun Y, Sun Y, Tian M, Wang S, Wang S, Wang X, Wang X, Wang Y, Wang Y, Wong CCL, Xiang AP, Xiao Y, Xie Z, Xu D, Ye J, Yue R, Zhang C, Zhang H, Zhang L, Zhang W, Zhang Y, Zhang Y, Zhang Z, Zhao T, Zhao Y, Zhu D, Zou W, Pei G, Liu GH, 2023
- Research progress on targeting DNA damage repair to delay aging, Zhang Weina, Chen Yu, Mao Zhiyong, 2023
Awards
- 2023 - Best Presentation Award at National Youth Physiology Academic Report
- 2022 - Shanghai Medical Science and Technology Award
- 2021 - Tongji University Excellence Award
- 2022 - Tongji University Outstanding Doctoral Thesis
