Areas of Focus
- 乳腺癌及妇科肿瘤相关DNA修复调控机制
- 靶向DNA修复预防及治疗乳腺癌和妇科肿瘤的新方法
Work Experience
- 2013年至今：同济大学生命科学与技术学院 - 助理研究员、副研究员、副教授
Academic Background & Achievements
- 2004年 - 学士学位：南京大学生命科学学院
- 2013年 - 博士学位：美国罗彻斯特大学生物系
- 在PNAS、Nucleic Acids Res.、Oncogene、JBC等重要学术期刊发表通讯、共同通讯、第一及共同第一作者论文10余篇
Publications
- Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors, Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y*, Sun FL*, Mao Z*, 2020
- A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y*, Gorbunova V*,Mao Z*, 2019
- The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression, Zhang F, Tang H, Jiang Y*,Mao Z*, 2017
- Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y*,Mao Z*, 2018
- POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions, Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y*, Li Lan*,Mao Z*, 2017
- Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer, Hu Z, Cai B, Wang M, Wen X, Geng A, Hu X, Xue R, Mao Z, Jiang Y*, Wan X*, 2020
- Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells, Cai B, Hu Z, Tang H, Hu Z, Mao Z, Liu B, Xu X, Jiang Y*, Wan X*, 2020
- Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells, Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y*, 2015
- Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells, Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L, 2013
- DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells, Mao Z#, Jiang Y#, Liu X, Seluanov A, Gorbunova V, 2009
