Areas of Focus
- Breast cancer and gynecological tumors related DNA repair regulation mechanisms
- Targeted DNA repair prevention and treatment methods for breast cancer and gynecological tumors
Work Experience
- 2013 - Present: Tongji University, School of Life Science and Technology - Assistant Researcher, Associate Researcher, Associate Professor
Academic Background & Achievements
- 2004 - Bachelor's Degree: Nanjing University, School of Life Sciences
- 2013 - PhD: University of Rochester, Department of Biology
- Published over 10 papers as first or corresponding author in journals like PNAS, Nucleic Acids Res., Oncogene, JBC
Publications
- Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors, Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y*, Sun FL*, Mao Z*, 2020
- A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites, Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, SuT, ShiJ, Jiang C, Tian X, SeluanovA, HuangJ, WanX, Jiang Y*, Gorbunova V*,Mao Z*, 2019
- The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression, Zhang F, Tang H, Jiang Y*,Mao Z*, 2017
- Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy, Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y*,Mao Z*, 2018
- POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions, Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y*, Li Lan*,Mao Z*, 2017
- Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer, Hu Z, Cai B, Wang M, Wen X, Geng A, Hu X, Xue R, Mao Z, Jiang Y*, Wan X*, 2020
- Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells, Cai B, Hu Z, Tang H, Hu Z, Mao Z, Liu B, Xu X, Jiang Y*, Wan X*, 2020
- Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells, Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y*, 2015
- Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells, Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L, 2013
- DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells, Mao Z#, Jiang Y#, Liu X, Seluanov A, Gorbunova V, 2009
