Areas of Focus
- Epigenetic regulation mechanisms during mammalian peri-implantation embryo development
- Epigenetic reprogramming molecular mechanisms in cloned embryos
- Establishment and optimization of gene editing and epigenetic editing techniques
Work Experience
- 2024.3 to present - Tongji University, School of Life Sciences and Technology, Associate Professor
- 2021.3-2024.3 - Tongji University, Biomedical Engineering, Postdoctoral Researcher
- 2017.9-2021.3 - Tongji University, School of Life Sciences and Technology, PhD Candidate
Academic Background & Achievements
- 2021.3-2024.3 Tongji University, Biomedical Engineering, Postdoctoral
- 2017.9-2021.3 Tongji University, School of Life Sciences and Technology, PhD
- 2014.9-2017.6 Northwest A&F University, College of Veterinary Medicine, Master's
- 2010.9-2014.6 Qingdao Agricultural University, College of Animal Science and Technology, Bachelor
- Published in Nature Cell Biology, Nature Communications, National Science Review
- Hosted National Natural Science Foundation of China Youth Project, Postdoctoral Surface Project
Publications
- Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos, Li Y, Zheng C, Liu Y, He J, Zhang Q, Zhang Y, Kou X, Zhao Y, Liu K, Bai D, Jia Y, Han X, Sheng Y, Yin J, Wang H, Gao S, Liu W, Gao S, 2023
- Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation, Li Y, Weng Y, Bai D, Jia Y, Liu Y, Zhang Y, Kou X, Zhao Y, Ruan J, Chen J, Yin J, Wang H, Teng X, Wang Z, Liu W, Gao S, 2020
- Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo, Yang H, Bai D, Li Y, Yu Z, Wang C, Sheng Y, Liu W, Gao S, Zhang Y, 2022
- Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos, Wang Y, Li Y, Luan D, Kang J, He R, Zhang Y, Quan F, 2020
- FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development, Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C, 2022
- N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition, Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S, 2022
- Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos, Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X, Jiang C, Gao S, 2020
- Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue cause placental defects and implantation failure in mouse IVF embryos, Bai D, Sun J, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C, Gao S, Liu W, 2022
- Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring, Jia Y, Liu W, Bai D, Zhang Y, Li Y, Liu Y, Yin J, Chen Q, Ye M, Zhao Y, Kou X, Wang H, Gao S, Li K, Chen M, 2022
Awards
- China Postdoctoral Innovative Talent Support Plan
- Shanghai 'Super Postdoctoral' Funding
