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Yanhe Li
Life Science
Tongji University
Shanghai
Language: Chinese, English
Epigenetics
Embryo Development
Peri-Implantation
Mammalian
Cloned Embryos
Reprogramming
Molecular Mechanisms
Gene Editing
Epigenetic Editing
Technique Optimization
Areas of Focus
- Epigenetic regulation mechanisms during mammalian peri-implantation embryo development
- Epigenetic reprogramming molecular mechanisms in cloned embryos
- Establishment and optimization of gene editing and epigenetic editing techniques
Work Experience
- 2024.3-present Associate Professor at Tongji University, School of Life Science and Technology
- 2021.3-2024.3 Postdoctoral Researcher at Tongji University, School of Biomedical Engineering
- 2017.9-2021.3 PhD Candidate at Tongji University, School of Life Science and Technology
Academic Background & Achievements
- 2021.3-2024.3 Postdoctoral Researcher at Tongji University, School of Biomedical Engineering
- 2017.9-2021.3 PhD in Life Science and Technology, Tongji University
- 2014.9-2017.6 Master's in Veterinary Medicine, Northwest A&F University
- 2010.9-2014.6 Bachelor in Animal Science and Technology, Qingdao Agricultural University
- Published in Nature Cell Biology, Nature Communications, National Science Review
- Hosted National Natural Science Foundation of China Youth Project
Publications
- Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos, Li Y, et al., 2023
- Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation, Li Y, et al., 2020
- Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo, Yang H, et al., 2022
- Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos, Wang Y, et al., 2020
- FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development, Wei J, et al., 2022
- N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition, Wu Y, et al., 2022
- Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos, Chen M, et al., 2020
- Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue cause placental defects and implantation failure in mouse IVF embryos, Bai D, et al., 2022
- Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring, Jia Y, et al., 2022
Awards
- China Postdoctoral Science Foundation Innovation Talent Support Plan
- Shanghai 'Super Postdoctor' Funding
