Areas of Focus
- Regulatory mechanisms of key transcription factors in early mammalian embryonic development
- Epigenetic regulatory mechanisms in the development of human primordial germ cells
- Molecular mechanisms of epigenetic defects and reprogramming induced by nuclear transplantation
- Establishment and optimization of single-cell and micro-epigenomic sequencing methods
Work Experience
- 2017.6—2020.5 Tongji University, School of Life Sciences and Technology - Postdoctoral Researcher
- 2020.5—2023.12 Tongji University, School of Life Sciences and Technology - Assistant Professor
- 2023.12—Present Tongji University, School of Life Sciences and Technology - Associate Professor
Academic Background & Achievements
- 2008.9—2012.7 Bachelor: Beijing Normal University, School of Life Sciences and Technology
- 2012.9—2017.6 PhD: Tsinghua University, School of Life Sciences, Beijing Institute of Life Sciences
- Published in international journals such as Cell Stem Cell, Developmental Cell, and Cell Reports Medicine
- Hosted national and Shanghai city science funds
Publications
- Defining a TFAP2C-centered transcription factor network during murine peri-implantation, Gao Rui
- Gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection, Gao Rui
- ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice, Gao Rui, 2024
- Resetting histone modifications during human prenatal germline development, Gao Rui, 2023
- Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development, Gao Rui, 2023
- Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos, Gao Rui, 2021
- Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs, Gao Rui, 2019
- Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos, Gao Rui, 2018
- Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state, Gao Rui, 2017
- Progress in understanding epigenetic remodeling during induced pluripotency, Gao Rui, 2015
