Areas of Focus
- Mechanisms of longevity-related DNA repair and genomic stability
- New functions of longevity genes in maintaining genomic stability
- Mechanisms by which longevity organisms maintain genomic stability
- Targeted genomic stability interventions for aging and related diseases
Work Experience
- 2020-09 - Present: Tongji University, Research Intern, Assistant Researcher, Pre-appointed Assistant Professor
Academic Background & Achievements
- 2020 - PhD in Biology: Tongji University
- Doctoral Supervisor: Professor Mao Zhiyong
- Hosted National Natural Science Foundation Youth Project (2021)
- Hosted Shanghai Science and Technology Committee Sail Plan (2021)
- Received Shanghai Medical Science and Technology Award (2021)
- Received Outstanding Doctoral Dissertation from Tongji University (2022)
Publications
- SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner, Geng A, Sun J, Tang H, Yu Y, Wang X, Zhang J, Wang X, Sun X, Zhou X, Gao N, Tan R, Xu Z, Jiang Y, Mao Z, 2024
- The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2, Geng A, Tang H, Huang J, Qian Z, Qin N, Yao Y, Xu Z, Chen H, Lan L, Xie H, Zhang J, Jiang Y, Mao Z, 2020
- Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion, Tang H, Geng A, Zhang T, Wang C, Jiang Y, Mao Z, 2019
- Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors, Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y, Sun F, Mao Z, 2020
- Chrysin impairs genomic stability by suppressing DNA double-strand break repair in breast cancer cells, Geng A, Xu S, Yao Y, Qian Z, Wang X, Sun J, Zhang J, Shi F, Chen Z, Zhang W, Mao Z, Lu W, Jiang Y, 2022
- Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair, Qian Z, Feng N, Geng A, 2023
Awards
- Shanghai Medical Science and Technology Award (2021): Detail not specified
- Outstanding Doctoral Dissertation from Tongji University (2022): Detail not specified
