1983 - Bachelor's Degree in Chemistry: Lanzhou University
1986 - Master's Degree in Biochemistry: Shanghai Institute of Biochemistry
1994 - Ph.D. in Molecular Genetics and Cell Biology: University of Chicago
1994-1997 - Postdoctoral Research: Howard Hughes Medical Institute, Harvard Medical School
1997-2019 - National Cancer Institute, USA - Tenure-track Researcher, Senior Investigator, and Head of the Laboratory of Stem Cell Regulation and Animal Aging
2020-present - Fudan University - Distinguished Professor, School of Life Sciences and Institute of Metabolism and Integrative Biology, Zhongshan Hospital
2017 - NIH Scientific Breakthrough Team Award
2009 - NCI Director's Innovation Award
2006 - NCI Annual Best Achievement for Research on Tumor Suppressor Gene BHD
2001 - NCI Researcher Award
2000 - US Army Breast Cancer Research Award
1997 - Charles Harkin Cancer Research Award, USA
1995 - Leukemia Society of America Postdoctoral Fellowship
1994 - NIH Postdoctoral Fellowship Award
Research
Maintenance of organismal mass and aging-related diseases: New coordinated cell death regulation, anti-tumor immunity, neurodegenerative diseases, and aging
Arf1 ablation in colorectal cancer cells activates a super signal complex in DC to enhance anti-tumor immunity, Ma, H., Fang, W., Li, Q., Yuetong Wang, Y., and Hou, S. X., 2023
A Neuron-Immune Circuit Regulates Neurodegeneration in the Hindbrain and Spinal cord of ARF1-Ablated Mice, Wang, G., Jin, S., Liu, J., Li, X., Dai, P., Li, Q., Liu, H., Wang, Y., and Hou, S. X., 2023
Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-kB-CCL5 pathway, Wang, N., Yao, T., Luo, C., Sun, L., Wang, Y., and Hou, S. X., 2023
Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila, Aggarwal, P., Liu, Z., Cheng, G. Q., Singh, S. R., Shi, C., Chen, Y., Sun, L. V., and Hou, S. X., 2022
Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome, Wang, G., Yin, W., Shin, H., Tian, Q., Lu, W., and Hou, S. X., 2021
Arf1-mediated Lipid Metabolism Sustains Cancer Stem Cells and Its ablation Induces Anti-tumor Immune Responses in Mice, Wang, G., Xu, J., Zhao, J., Yin, W., Liu, D., Chen, W., and Hou, S. X., 2020
The Lipolysis Pathway Sustains Normal and Transformed Stem Cells in Adult Drosophila, Singh, S. R., Zeng, X., Zhao, J., Liu, Y., Hou, G., Liu, H, and Hou, S. X., 2016
Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila, Liu, Y, Ge, Q., Chan, B., Liu, H., Singh, S. R., Manley, J., Lee, J., Weidenman, A. M., Hou, G., and Hou, S. X., 2016
The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis, Singh, S. R., Liu, Y., Zhao, J., Zeng, X., and Hou, S. X., 2016
Genome-Wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila, Zeng, X., Han, L., Singh, S. R., Liu, H., Neumüller, R. A., Yan, D., Hu, Y., Liu, Y., Liu, W., Lin, X., and Hou, S. X., 2015
Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut, Zeng, X., and Hou, S. X., 2015
The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine, Zeng, X., Lin, X., and Hou, S. X., 2013
Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis, Zeng, X., and Hou, S. X., 2012
Kidney stem cells found in adult zebrafish, Zeng, X., and Hou, S. X., 2011
The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus), Singh, S. R., Zeng, X., Zheng, Z., and Hou, S. X., 2011
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis, Ande, S., Orri, K., Chen, X., Coppola, V., Tessarollo, L., Keller, J. R., and Hou, S. X., 2010
The adult Drosophila Malpiphian Tubules are maintained by multipotent stem cells, Singh, S. R., Liu, W., and Hou, S. X., 2007
The Drosophila homologue of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance, Singh, S. R., Zhen, W., Zheng, Z. Y., Wang, H., Oh, S. W., Liu, W., Zbar, B., Schmidt, L. S., and Hou, S. X., 2006
A Rap-GEF/Rap GTPase signaling controls stem cell maintenance through regulating adherens junction positioning and cell adhesion in Drosophila testis, Wang, H., Singh, S. R., Zheng, Z. Y., Oh, S. W., Chen, X., Edwards, K., and Hou, S. X., 2006
JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila, Singh, S. R., Chen, X., and Hou, S. X., 2005
Cyclin D-Cdk4 and Cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila, Chen, X., Oh, S. W., Zheng, Z., Chen, H. W., Shin, H. H., and Hou, S. X., 2003
The JAK/STAT pathway in model organisms: Emerging roles in cell movement, Hou, S. X., Zheng, Z., Chen, X., and Perrimon, N., 2002
mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family, Chen, H. W., Chen, X., Oh, S. W., Marrinissen, M. J., Gutkind, J. S., and Hou, S. X., 2002
Drosophila Jun relays the JNK signal transduction pathway to the DPP signal transduction pathway in regulating epithelial cell sheet movement, Hou, S. X., Goldstein, E. S., and Perrimon, N., 1997
Marelle acts downstream of the Drosophila Hop/JAK kinase and encodes a protein similar to the mammalian STATs, Hou, S. X., Melnick, M. B., and Perrimon, N., 1996
The torso receptor tyrosine kinase activates raf in a Ras-independent pathway, Hou, S. X., Chou, T. B., Melnick, M. B., and Perrimon, N., 1995
