Areas of Focus
- Design and optimization of biological macromolecules
- Mechanism and regulation of gene editing systems
- Artificial intelligence design technology for proteins
Work Experience
- 2004-present - Fudan University - Professor
- 2005-present - Fudan University - Doctoral Supervisor
Academic Background & Achievements
- 1991 - Bachelor's Degree in Chemistry: Zhejiang University
- 1994 - Master's Degree in Physical Chemistry: Zhejiang University
- 1998 - Ph.D. in Physical Chemistry: Zhejiang University
- 1999-2000 - Postdoctoral Research in Molecular Biophysics: Humboldt University of Berlin
- 2001-2003 - Research in Molecular Biophysics: Humboldt University of Berlin and National Sun Yat-sen University
- 2004 - Joined Fudan University, School of Life Sciences
- Published nearly 90 academic papers
- Received nearly 20 authorized invention patents
Publications
- Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2, Q. Qin, X. Jiang, L. Huo, J. Qian, H. Yu, H. Zhu, W. Du, Y. Cao, X. Zhang, Q. Huang, 2024
- Structure-guided design of a trivalent nanobody cluster targeting SARS-CoV-2 spike protein, X. Jiang, Q. Qin, H. Zhu, J. Qian, Q. Huang, 2024
- De novo design of DNA aptamers that target okadaic acid (OA) by docking-then-assembling of single nucleotides, M. Song, Y. Li, R. Gao, J. Liu, Q. Huang, 2022
- Deep-learning with synthetic data enables automated picking of cryo-EM particle images of biological macromolecules, R. Yao, J. Qian, Q. Huang, 2020
- Surface binding energy landscapes affect phosphodiesterase isoform-specific inhibitor selectivity, Q. Liu, A. Herrmann, Q. Huang, 2019
- Structural insights into DNA cleavage activation of CRISPR-Cas9 system, C. Huai, G. Li, R. Yao, Y. Zhang, M. Cao, L. Kong, C. Jia, H. Yuan, H. Chen, D. Lu, Q. Huang, 2017
- X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity, J. Zhu, Q. Yang, D. Dai, Q. Huang, 2013
- Calculating pH-dependent free energy of proteins by using Monte Carlo protonation probabilities of ionizable residues, Q. Huang, A. Herrmann, 2012
- Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study, Q. Huang, C.-L. Chen, A. Herrmann, 2004
- Protonation and stability of the globular domain of influenza virus hemagglutinin, Q. Huang, R. Opitz, E.-W. Knapp, A. Herrmann, 2002
Awards
- Golden Bridge Award (Second Contributor): China Technology Market Association
- Second Prize for Technological Invention: Ministry of Education
- Second Prize for Technological Invention: Shanghai
