Areas of Focus
- Molecular Mechanisms of Gene Translation and Regulation
- Mechanisms of Action and Resistance of Ribosome-Targeting Antibiotics
Work Experience
- 2008-2011 - Beijing Institute of Life Sciences - Postdoctoral Research
- 2011-2016 - Yale University - Research
- 2015-2016 - Howard Hughes Medical Institute - Research Specialist
- 2017-Present - Fudan University - Researcher, Doctoral Supervisor, PI of National Key Laboratory of Genetic Engineering
Academic Background & Achievements
- 2001 Bachelor's Degree: China Agricultural University
- 2008 PhD: Institute of Biophysics, Chinese Academy of Sciences
- 2008-2011 Postdoctoral Research: Beijing Institute of Life Sciences
- 2011-2016 Research: Yale University
- 2015-2016 Research Specialist: Howard Hughes Medical Institute
- 2017 Joined Fudan University
Publications
- Box C/D guide RNAs recognize maximal ten bases of substrates, Yangm, Z, Lin J., Ye K., 2016
- Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits, Zhang, C., Sun, Q., Chen, R., Chen, X., Lin, J., and Ye, K., 2016
- Elongation Factor 4 Remodels the A-site tRNA on the Ribosome, Gagnon, M. G.*, Lin, J.*, Steitz, T. A., 2016
- Conformational Changes of Elongation Factor G on the Ribosome During tRNA Translocation, Lin, J.*, Gagnon, M. G.*, Bulkley, D. & Steitz, T. A., 2015
- Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome, Gagnon, M. G.*, Lin, J.*, Bulkley, D. & Steitz, T. A., 2014
- Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis, Zhang, C., Lin, J., Liu, W. et al., 2014
- An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme, Lin, J.*, Lu, J.*, Feng, Y., Sun, M. & Ye, K., 2013
- Structure of the PolIIIalpha-tauc-DNA complex suggests an atomic model of the replisome, Liu, B., Lin, J. & Steitz, T. A., 2013
- Structural and functional analysis of the U3 snoRNA binding protein Rrp9, Zhang, L., Lin, J. & Ye, K., 2013
- Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases, Eiler, D., Lin, J., Simonetti, A., Klaholz, B. P. & Steitz, T. A., 2013
- Identification of cross-linked peptides from complex samples, Yang, B., Wu, YJ., Zhu, M., Fan SB, Lin, J., Zhang, K., et al., 2012
- Potential key bases of ribosomal RNA to kingdom-specific spectra of antibiotic susceptibility and the possible archaeal origin of eukaryotes, Xie, Q., Wang, Y., Lin, J., Qin, Y., Wang, Y., Bu, W., 2012
- Structural basis for site-specific ribose methylation by box C/D RNA protein complexes, Lin, J., Lai, S., Jia, R. et al., 2011
- Solution structure of the human HSPC280 protein, Lin, J., Zhou, T. & Wang, J., 2011
- Structure and molecular evolution of CDGSH iron-sulfur domains, Lin, J.*, Zhang, L.*, Lai, S. & Ye, K., 2011
- Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction, Xie, Q., Lin, J., Qin, Y., Zhou, J. & Bu, W., 2011
- Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase, Guo, B., Lin, J. & Ye, K., 2011
- Binding of reduced nicotinamide adenine dinucleotide phosphate destabilizes the iron-sulfur clusters of human mitoNEET, Zhou, T., Lin, J., Feng, Y. & Wang, J., 2010
- Structural organization of box C/D RNA-guided RNA methyltransferase, Ye, K., Jia, R., Lin, J. et al., 2009
- Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins, Lin, J., Zhou, T., Ye, K. & Wang, J., 2007
Awards
- Blavatnik Young Scientist Award (2015): New York Academy of Sciences
- Director's Paper Award (2007): Institute of Biophysics, Chinese Academy of Sciences
- Tan Jiazhen Foundation Jiuyuan Scholarship (2007)
- Tan Jiazhen Life Science Scholarship First Prize (1997)
