Professor | 林金钟 | 数字化转型顾问

Name	林金钟
Contact Information	linjinzhong@fudan.edu.cn
Language ability	中文, 英语
Province	上海

Name

林金钟

Contact Information

linjinzhong@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Life Sciences
Academic Background & Achievements	2001 学士学位: 中国农业大学 2008 博士学位: 中国科学院生物物理研究所 2008-2011 博士后研究: 北京生命科学研究所 2011-2016 科学研究: 耶鲁大学 2015-2016 研究专家: 霍华德休斯医学研究所 2017 加入复旦大学
Work Experience	2008-2011 - 北京生命科学研究所 - 博士后研究 2011-2016 - 耶鲁大学 - 科学研究 2015-2016 - 霍华德休斯医学研究所 - 研究专家 2017-至今 - 复旦大学 - 研究员、博士生导师、遗传工程国家重点实验室PI
Awards	Blavatnik青年科学家奖 (2015): 纽约科学院所长论文奖 (2007): 中国科学院生物物理所谈家桢基金九源奖学金 (2007) 谈家桢生命科学奖学金一等奖 (1997)

University/Lab Affiliation and Title

复旦大学

Faculty

Life Sciences

Academic Background & Achievements

2001 学士学位: 中国农业大学
2008 博士学位: 中国科学院生物物理研究所
2008-2011 博士后研究: 北京生命科学研究所
2011-2016 科学研究: 耶鲁大学
2015-2016 研究专家: 霍华德休斯医学研究所
2017 加入复旦大学

Work Experience

2008-2011 - 北京生命科学研究所 - 博士后研究
2011-2016 - 耶鲁大学 - 科学研究
2015-2016 - 霍华德休斯医学研究所 - 研究专家
2017-至今 - 复旦大学 - 研究员、博士生导师、遗传工程国家重点实验室PI

Awards

Blavatnik青年科学家奖 (2015): 纽约科学院
所长论文奖 (2007): 中国科学院生物物理所
谈家桢基金九源奖学金 (2007)
谈家桢生命科学奖学金一等奖 (1997)

Areas of Focus	基因翻译与调控的分子机制研究靶向核糖体抗生素的工作机制和耐药性机理的研究
Publications	Box C/D guide RNAs recognize maximal ten bases of substrates, Yangm, Z, Lin J., Ye K., 2016 Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits, Zhang, C., Sun, Q., Chen, R., Chen, X., Lin, J., and Ye, K., 2016 Elongation Factor 4 Remodels the A-site tRNA on the Ribosome, Gagnon, M. G., Lin, J., Steitz, T. A., 2016 Conformational Changes of Elongation Factor G on the Ribosome During tRNA Translocation, Lin, J., Gagnon, M. G., Bulkley, D. & Steitz, T. A., 2015 Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome, Gagnon, M. G., Lin, J., Bulkley, D. & Steitz, T. A., 2014 Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis, Zhang, C., Lin, J., Liu, W. et al., 2014 An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme, Lin, J., Lu, J., Feng, Y., Sun, M. & Ye, K., 2013 Structure of the PolIIIalpha-tauc-DNA complex suggests an atomic model of the replisome, Liu, B., Lin, J. & Steitz, T. A., 2013 Structural and functional analysis of the U3 snoRNA binding protein Rrp9, Zhang, L., Lin, J. & Ye, K., 2013 Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases, Eiler, D., Lin, J., Simonetti, A., Klaholz, B. P. & Steitz, T. A., 2013 Identification of cross-linked peptides from complex samples, Yang, B., Wu, YJ., Zhu, M., Fan SB, Lin, J., Zhang, K., et al., 2012 Potential key bases of ribosomal RNA to kingdom-specific spectra of antibiotic susceptibility and the possible archaeal origin of eukaryotes, Xie, Q., Wang, Y., Lin, J., Qin, Y., Wang, Y., Bu, W., 2012 Structural basis for site-specific ribose methylation by box C/D RNA protein complexes, Lin, J., Lai, S., Jia, R. et al., 2011 Solution structure of the human HSPC280 protein, Lin, J., Zhou, T. & Wang, J., 2011 Structure and molecular evolution of CDGSH iron-sulfur domains, Lin, J., Zhang, L., Lai, S. & Ye, K., 2011 Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction, Xie, Q., Lin, J., Qin, Y., Zhou, J. & Bu, W., 2011 Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase, Guo, B., Lin, J. & Ye, K., 2011 Binding of reduced nicotinamide adenine dinucleotide phosphate destabilizes the iron-sulfur clusters of human mitoNEET, Zhou, T., Lin, J., Feng, Y. & Wang, J., 2010 Structural organization of box C/D RNA-guided RNA methyltransferase, Ye, K., Jia, R., Lin, J. et al., 2009

Areas of Focus

基因翻译与调控的分子机制研究
靶向核糖体抗生素的工作机制和耐药性机理的研究

Publications

Box C/D guide RNAs recognize maximal ten bases of substrates, Yangm, Z, Lin J., Ye K., 2016
Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits, Zhang, C., Sun, Q., Chen, R., Chen, X., Lin, J., and Ye, K., 2016
Elongation Factor 4 Remodels the A-site tRNA on the Ribosome, Gagnon, M. G.*, Lin, J.*, Steitz, T. A., 2016
Conformational Changes of Elongation Factor G on the Ribosome During tRNA Translocation, Lin, J.*, Gagnon, M. G.*, Bulkley, D. & Steitz, T. A., 2015
Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome, Gagnon, M. G.*, Lin, J.*, Bulkley, D. & Steitz, T. A., 2014
Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis, Zhang, C., Lin, J., Liu, W. et al., 2014
An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme, Lin, J.*, Lu, J.*, Feng, Y., Sun, M. & Ye, K., 2013
Structure of the PolIIIalpha-tauc-DNA complex suggests an atomic model of the replisome, Liu, B., Lin, J. & Steitz, T. A., 2013
Structural and functional analysis of the U3 snoRNA binding protein Rrp9, Zhang, L., Lin, J. & Ye, K., 2013
Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases, Eiler, D., Lin, J., Simonetti, A., Klaholz, B. P. & Steitz, T. A., 2013
Identification of cross-linked peptides from complex samples, Yang, B., Wu, YJ., Zhu, M., Fan SB, Lin, J., Zhang, K., et al., 2012
Potential key bases of ribosomal RNA to kingdom-specific spectra of antibiotic susceptibility and the possible archaeal origin of eukaryotes, Xie, Q., Wang, Y., Lin, J., Qin, Y., Wang, Y., Bu, W., 2012
Structural basis for site-specific ribose methylation by box C/D RNA protein complexes, Lin, J., Lai, S., Jia, R. et al., 2011
Solution structure of the human HSPC280 protein, Lin, J., Zhou, T. & Wang, J., 2011
Structure and molecular evolution of CDGSH iron-sulfur domains, Lin, J.*, Zhang, L.*, Lai, S. & Ye, K., 2011
Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction, Xie, Q., Lin, J., Qin, Y., Zhou, J. & Bu, W., 2011
Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase, Guo, B., Lin, J. & Ye, K., 2011
Binding of reduced nicotinamide adenine dinucleotide phosphate destabilizes the iron-sulfur clusters of human mitoNEET, Zhou, T., Lin, J., Feng, Y. & Wang, J., 2010
Structural organization of box C/D RNA-guided RNA methyltransferase, Ye, K., Jia, R., Lin, J. et al., 2009

基因翻译调控 Mrna 蛋白质合成真核系统翻译起始非编码区原癌基因结构生物学分子生物学

李文阳 - 南方科技大学

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