Published over 40 SCI papers as corresponding author
2010-07 to 2016-06 - Fudan University - Research Assistant
2016-07 to 2017-11 - Fudan University - Young Associate Researcher
2017-12 to Present - Fudan University - Associate Researcher
Research
Mechanisms of high-frequency mutation genes in malignant tumors Molecular mechanisms and targeted therapy strategies for genetic and neurodegenerative diseases
mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1, Sun H, Jiao D, Zhao X, Chen Y, Shi Q, Lv Z, Li Y, G Wang C, Gao K, 2023
Excessive mitophagy drives FBXL4 mutation-caused mitochondrial DNA depletion syndrome, Gao K, Xu X, Wang C, 2023
Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome, Gao K, Chen Y, Wang C, 2023
Disruption of the Keap1-mTORC2 axis by Cancer-derived Keap1/mLST8 Mutations Leads to Oncogenic mTORC2-AKT Activation, Chen Y, Jiao D, He H, Sun H, Liu Y, Shi Q, Zhang P, Li Y, Mo R, Gao K, Wang C, 2023
DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma, Chang K, Chen Y, Zhang X, Zhang W, Xu T, Zeng B, Dai B, Xu F, Ye D, Wang C, 2023
FBXL4 Mutations Cause Excessive Mitophagy via BNIP3/BNIP3L Accumulation Leading to Mitochondrial DNA Depletion Syndrome, Chen Y, Jiao D, Liu Y, Xu X, Wang Y, Hexige S, Gao K, Chen Y, Zhao S, Ma L, Wang C, 2023
SPOP Mutations Promote Tumor Immune Escape in Endometrial Cancer via the IRF1–PD-L1 Axis, Gao K, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C, Wan X, 2023
SPOP Inhibits BRAF-dependent Tumorigenesis through Promoting Non-degradative Ubiquitination of BRAF, Feng K, Shi Q, Jiao D, Chen Y, Yang W, Su K, Wang Y, Huang Y, Zhang P, Li Y, Wang C, 2022
Lysosomal dysfunction, autophagic defects, and CLN5 accumulation underlie the pathogenesis of KCTD7-mutated neuronal ceroid lipofuscinoses, Wang Y, Wang H, Wang C, 2022
KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses, Wang Y, Cao X, Liu P, Zeng W, Peng R, Shi Q, Feng K, Zhang P, Sun H, Wang C, Wang H, 2022
Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer, Gao K, Shi Q, Liu Y, Wang C, 2022
DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs, Jiao D, Chen Y, Wang Y, Sun H, Shi Q, Zhang L, Zhao X, Liu Y, He H, Lv Z, Liu C, Zhang P, Gao K, Huang Y, Li Y, Li L, Wang C, 2022
SPOP Mutations Promote p62/SQSTM1-dependent Autophagy and Nrf2 Activation in Prostate Cancer, Shi Q, Jin X, Zhang P, Li Q, He H, Zhao X, Lv Z, Zhao S, Li Y, Gao K, Wang C, 2022
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation, Zhang P, Gao K, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C, 2022
Calcineurin Inactivation Inhibits Pyruvate Dehydrogenase Complex Activity and Induces the Warburg Effect, Zhang J, Zhang L, Nie J, Lin Y, Li Y, Xu W, Zhao J, Zhao SM, Wang C, 2021
SPOP mutation induces DNA methylation via stabilizing GLP/G9a, Zhang J, Gao K, Xie H, Wang D, Zhang P, Wei T, Yan Y, Pan Y, Chen H, Shi Q, Yao Li Y, Zhao S, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, Wang L, Wang C, Huang H, 2021
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition, Ma J, Shi Q, Cui G, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, Georges Mer, Ye D, Wang C, Huang H, 2021
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis, Jin X, Qing S, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S, Wang C, Gao K, 2021
Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex, Zhang L, Zhang J, Liu Y, Zhang P, Nie J, Zhao R, Shi Q, Sun H, Jiao D, Chen Y, Zhao X, Huang Y, Li Y, Zhao JY, Xu W, Zhao SM, Wang C, 2021
CRL3-SPOP Ubiquitin Ligase Complex Suppresses the Growth of Diffuse Large B-cell Lymphoma by Negatively Regulating the MyD88/NF-κB Signaling, Jin X, Shi Q, Li Q, Zhou L, Wang J, Jiang L, Zhao X, Feng K, Lin T, Lin Z, Zhuang H, Yang J, Hu C, Zhang L, Shen L, Lu Y, Zhu J, Wang H, Qi H, Meng X, Xi Y, Pan J, Fang S, Tian H, Zhou C, Zhang P, Gao K, Zhao S, Li Y, Gong Z, Wang C, 2020
Prostate Cancer-associated SPOP Mutations Enhance Cancer Cell Survival and Docetaxel Resistance by Upregulating Caprin1-dependent Stress Granule Assembly, Shi Q, Zhu Y, Ma J, Chang K, Ding D, Bai Y, Gao K, Zhang P, Mo R, Feng K, Zhao X, Zhang L, Sun H, Jiao D, Chen Y, Sun Y, Zhao S, Huang H, Li Y, Ren S, Wang C, 2019
SPOP Promotes ATF2 Ubiquitination and Degradation to Suppress Prostate Cancer Progression, Ma J, Peng J, Chang K, Shi Q, Gan H, Gao K, Feng K, Xu F, Zhang H, Dai B, Zhu Y, Shi G, Shen Y, Zhu Y, Qin X, Li Y, Zhang P, Ye D, Wang C, 2018
iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation, Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao S, Li Y, Zhang P, Wang C, 2018
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation, Zhang P, Wang D, Ren S, Zhao Y, Gao K, Ye Z, Wang S, Lin D, Pang X, Pan C, Zhu Y, Yan Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Wang L, Wang Y, Chen Y, Sun Y, Wang C, Huang H, 2017
Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α (ERα) protein turnover, Zhang P, Gao K, Jin X, Ma J, Peng J, Tang Y, Zhang Y, An J, Yan J, Dong Y, Huang H, Yu L, Wang C, 2015
Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils, Gao K, Tang W, Wang D, Zhang P, Yu L, Wang C, Wu D, 2015
Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants, Zhang P, Gao K, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C, 2014
Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants, An J, Wang C, Deng Y, Yu L, Huang H, 2014
HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas, Xiao Q, Qu K, Wang C, Kong Y, Liu C, Jiang D, Saiyin H, Jia F, Ni C, Chen T, Zhang Y, Zhang P, Qin W, Sun Q, Wang H, Yi Q, Liu J, Huang H, Yu L, 2013
Area of Focus
Genomics | Proteomics | Mass Spectrometry | Bioinformatics | Cancer | Biomarkers | Drug Targets | Cell Communication | Mitochondria | Autophagy
