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Boxun Lu
Life Science
Fudan University
Shanghai
Language: Chinese, English
Neurodegenerative Diseases
Drug Development
Biophysics
Chemical Biology
Huntington'S Disease
Autophagy
Mutant Htt
Gpr52
Mapk11
Hipk3
Areas of Focus
- Neurodegenerative Diseases
- Original Drug Development Strategies
Academic Background & Achievements
- Graduated with a Bachelor's degree from Fudan University
- Graduated with a Ph.D. from the University of Pennsylvania
- Received National Outstanding Youth Fund
- Received National Excellent Youth Fund
- Received National Original Project Fund
- Received Newton Advanced Fellowship from the British Academy of Medical Sciences
- Received Xplorer Prize
- Received Youth Science Award from the Ministry of Education
- Received Gu Xiaocheng Award from the Wu Rui Memorial Foundation
- Received Shanghai Youth Science and Technology Talent Award
Publications
- Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds, Li Z, et.al, Ding Y*, Fei Y*, Lu B*, 2019
- Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes, Song H, et.al, Lu B, 2018
- Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington’s disease models, Yu M, Fu Y, Liang Y, et.al, Lu B, 2017
- A Toxic Mutant Huntingtin Species Is Resistant to Selective Autophagy, Fu Y, Wu P, Pan Y, Sun X, Difiglia M, Lu B, 2017
- A Striatal-enriched Intronic GPCR Modulates Huntingtin Levels and Toxicity, Yao Y, Cui X, Al-Ramah I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu Z, Ma L, Botas J, Boxun Lu, 2015
Awards
- National Outstanding Youth Fund
- National Excellent Youth Fund
- National Original Project Fund
- Newton Advanced Fellowship from the British Academy of Medical Sciences
- Xplorer Prize
- Youth Science Award from the Ministry of Education
- Gu Xiaocheng Award from the Wu Rui Memorial Foundation
- Shanghai Youth Science and Technology Talent Award
