2004 PhD: University of Science and Technology of China
2009 Researcher: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2014 Outstanding Young Scientist: Chinese Academy of Sciences
2017 Distinguished Researcher: Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
2020 Distinguished Professor: Fudan University
2004-2009 - University of Pennsylvania - Postdoctoral Researcher
2009-2014 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2017-2020 - Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences - Distinguished Researcher
2020-Present - Fudan University - Distinguished Professor
2014: Outstanding Young Scientist, Chinese Academy of Sciences
2017: National Natural Science Foundation of China Medical Department 'Outstanding Youth' Grant
Research
Molecular and cellular signaling mechanisms of tumorigenesis and immune response
A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells, Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, Liao J, Nie P, Wen F, Ju J et al., 2021
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Tang Y, Fang G, Guo F, Zhang H, Chen X, An L, Chen M, Zhou L, Wang W, Ye T et al., 2020
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al., 2020
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling, Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al., 2020
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al., 2019
TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts, Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z, 2019
Targeting IRF3 as a YAP agonist therapy against gastric cancer, Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z, 2018
The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer, Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al., 2018
DNA-binding mechanism of the Hippo pathway transcription factor TEAD4, Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z, 2017
VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z, 2017
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100, Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z, 2015
Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling, Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al., 2015
Structural dissection of Hippo signaling, Shi Z, Jiao S, Zhou Z, 2015
The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6, Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al., 2015
A non-canonical role of the p97 complex in RIG-I antiviral signaling, Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al., 2015
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex, Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al., 2014
Structure of MST2 SARAH domain provides insights into its interaction with RAPL, Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al., 2014
Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1, Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z, 2014
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer, Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al., 2014
Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex, Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al., 2014
Structural mechanism of CCM3 heterodimerization with GCKIII kinases, Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al., 2013
Structure of the MST4 in complex with MO25 provides insights into its activation mechanism, Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al., 2013
Structural insights into SUN-KASH complexes across the nuclear envelope, Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z, 2012
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function, Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al., 2012
