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周兆才
Life Science
复旦大学
上海
Language: 中文, 英文
肿瘤发生
免疫应答
分子信号
细胞信号
胃癌
靶向治疗
生物标志物
器官生长
稳态
免疫治疗
Areas of Focus
- 肿瘤发生及免疫应答的分子细胞信号机制
Work Experience
- 2004-2009 - 宾夕法尼亚大学 - 博士后研究员
- 2009-2014 - 中国科学院上海生化与细胞所 - 研究员
- 2017-2020 - 中国科学院分子细胞科学卓越创新中心 - 特聘研究员
- 2020-至今 - 复旦大学 - 特聘教授
Academic Background & Achievements
- 2004 博士: 中国科学技术大学
- 2009 研究员: 中国科学院上海生化与细胞所
- 2014 杰出青年科技创新人才: 中国科学院
- 2017 特聘研究员: 中国科学院分子细胞科学卓越创新中心
- 2020 特聘教授: 复旦大学
Publications
- A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells, Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, Liao J, Nie P, Wen F, Ju J et al., 2021
- Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, Tang Y, Fang G, Guo F, Zhang H, Chen X, An L, Chen M, Zhou L, Wang W, Ye T et al., 2020
- MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al., 2020
- Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling, Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al., 2020
- Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al., 2019
- TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts, Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z, 2019
- Targeting IRF3 as a YAP agonist therapy against gastric cancer, Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z, 2018
- The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer, Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al., 2018
- DNA-binding mechanism of the Hippo pathway transcription factor TEAD4, Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z, 2017
- VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Jiao S, Li C, Hao Q, Miao H, Zhang L, Li
Awards
- 2014: 中国科学院杰出青年科技创新人才
- 2017: 国家自然科学基金委医学部“杰青”资助
