Professor | Hongyan Wang | Asia Growth Partners

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Name	Hongyan Wang
Contact Information	wanghy@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Hongyan Wang

Contact Information

wanghy@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	1989 - Bachelor's Degree in Biology: Shaanxi Normal University 1999 - Ph.D. in Neurobiology: Shanghai Brain Research Institute, Chinese Academy of Sciences 2010 - National Outstanding Youth Fund 2012 - Chief Scientist of the '973' Project on Birth Defects Research
Work Experience	1999-2001 - Postdoctoral Researcher: Monell Chemical Senses Center, USA 2002-2006 - Research Assistant: Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, USA 2007.05-Present - Distinguished Professor/Doctoral Supervisor: Fudan University Current - Executive Dean: Institute of Reproduction and Development, Fudan University Current - PI: School of Life Sciences, Fudan University
Awards	2016 - National Maternal and Child Health Science and Technology Award, First Prize in Natural Science: 'Mechanism of New Mutations Causing Birth Defects' 2015 - Ministry of Education Natural Science First Prize: 'Genetic Analysis of Major Birth Defects in the Chinese Population' 2013 - National May 1st Labor Medal 2012 - WuXi AppTec Life Chemistry Outstanding Achievement Award 2011 - Tan Jiazhen Life Science Innovation Award 2010 - China Young Female Scientist Award 2004, 2005, 2006 - President Award, Society for Gynecologic Investigation, USA

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

1989 - Bachelor's Degree in Biology: Shaanxi Normal University
1999 - Ph.D. in Neurobiology: Shanghai Brain Research Institute, Chinese Academy of Sciences
2010 - National Outstanding Youth Fund
2012 - Chief Scientist of the '973' Project on Birth Defects Research

Work Experience

1999-2001 - Postdoctoral Researcher: Monell Chemical Senses Center, USA
2002-2006 - Research Assistant: Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, USA
2007.05-Present - Distinguished Professor/Doctoral Supervisor: Fudan University
Current - Executive Dean: Institute of Reproduction and Development, Fudan University
Current - PI: School of Life Sciences, Fudan University

Awards

2016 - National Maternal and Child Health Science and Technology Award, First Prize in Natural Science: 'Mechanism of New Mutations Causing Birth Defects'
2015 - Ministry of Education Natural Science First Prize: 'Genetic Analysis of Major Birth Defects in the Chinese Population'
2013 - National May 1st Labor Medal
2012 - WuXi AppTec Life Chemistry Outstanding Achievement Award
2011 - Tan Jiazhen Life Science Innovation Award
2010 - China Young Female Scientist Award
2004, 2005, 2006 - President Award, Society for Gynecologic Investigation, USA

Areas of Focus	Genetic causes and molecular mechanisms of major birth defects such as congenital heart disease and neural tube defects Genomic structural variation, pathogenic gene mutation detection and functional analysis Regulation of gene expression by epigenetic modifications Genetic basis of metabolic imbalances such as folate deficiency and their impact on developmental signaling pathways leading to birth defects
Publications	The Circulating Folate Decrease Induced by a Fidgetin Intronic Variant Is Associated with Reduced Congenital Heart Disease Susceptibility, Wang D, Wang F, Shi KH, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao B, Zhao SM, Wang HY, Zhao JY, 2017 Genetic variants reducing MTR gene expression increase risk of congenital heart disease in a Chinese population, Zhao JY, Qiao B, Duan WY, Gong XH, Jiang SS, Ye ZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY, Jin L, Wang HY, 2013 A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in Han Chinese Population, Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY, 2013 A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population, Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B, Wang HY, 2012 VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects, Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY, 2010 A Functional SNP in the Promoter of the SERPINH1 Gene Encoding Hsp47 Increases Risk of Preterm Premature Rupture of Membranes and Preterm Birth in African-Americans, Wang H, Parry S, Macones G, Sammel MD, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2006 Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM), Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2004 Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China, Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, St Clair D, He L, 2000

Areas of Focus

Genetic causes and molecular mechanisms of major birth defects such as congenital heart disease and neural tube defects
Genomic structural variation, pathogenic gene mutation detection and functional analysis
Regulation of gene expression by epigenetic modifications
Genetic basis of metabolic imbalances such as folate deficiency and their impact on developmental signaling pathways leading to birth defects

Publications

The Circulating Folate Decrease Induced by a Fidgetin Intronic Variant Is Associated with Reduced Congenital Heart Disease Susceptibility, Wang D, Wang F, Shi KH, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao B, Zhao SM, Wang HY, Zhao JY, 2017
Genetic variants reducing MTR gene expression increase risk of congenital heart disease in a Chinese population, Zhao JY, Qiao B, Duan WY, Gong XH, Jiang SS, Ye ZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY, Jin L, Wang HY, 2013
A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in Han Chinese Population, Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY, 2013
A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population, Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B, Wang HY, 2012
VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects, Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY, 2010
A Functional SNP in the Promoter of the SERPINH1 Gene Encoding Hsp47 Increases Risk of Preterm Premature Rupture of Membranes and Preterm Birth in African-Americans, Wang H, Parry S, Macones G, Sammel MD, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2006
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM), Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2004
Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China, Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, St Clair D, He L, 2000

Congenital Heart Disease Neural Tube Defects Genetic Causes Molecular Mechanisms Genomic Structural Variation Pathogenic Gene Mutation Functional Analysis Epigenetic Modifications Gene Expression Regulation Folate Deficiency

Hongyan Wang - Fudan University

Xueyan Yang - Fudan University

Hongyan Wang - Fudan University

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