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Hongyan Wang
Life Science
Fudan University
Shanghai
Language: Chinese, English
Congenital Heart Disease
Neural Tube Defects
Genetic Causes
Molecular Mechanisms
Genomic Structural Variation
Pathogenic Gene Mutation
Functional Analysis
Epigenetic Modifications
Gene Expression Regulation
Folate Deficiency
Areas of Focus
- Genetic causes and molecular mechanisms of major birth defects such as congenital heart disease and neural tube defects
- Genomic structural variation, pathogenic gene mutation detection and functional analysis
- Regulation of gene expression by epigenetic modifications
- Genetic basis of metabolic imbalances such as folate deficiency and their impact on developmental signaling pathways leading to birth defects
Work Experience
- 1999-2001 - Postdoctoral Researcher: Monell Chemical Senses Center, USA
- 2002-2006 - Research Assistant: Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, USA
- 2007.05-Present - Distinguished Professor/Doctoral Supervisor: Fudan University
- Current - Executive Dean: Institute of Reproduction and Development, Fudan University
- Current - PI: School of Life Sciences, Fudan University
Academic Background & Achievements
- 1989 - Bachelor's Degree in Biology: Shaanxi Normal University
- 1999 - Ph.D. in Neurobiology: Shanghai Brain Research Institute, Chinese Academy of Sciences
- 2010 - National Outstanding Youth Fund
- 2012 - Chief Scientist of the '973' Project on Birth Defects Research
Publications
- The Circulating Folate Decrease Induced by a Fidgetin Intronic Variant Is Associated with Reduced Congenital Heart Disease Susceptibility, Wang D, Wang F, Shi KH, Tao H, Li Y, Zhao R, Lu H, Duan WY, Qiao B, Zhao SM, Wang HY, Zhao JY, 2017
- Genetic variants reducing MTR gene expression increase risk of congenital heart disease in a Chinese population, Zhao JY, Qiao B, Duan WY, Gong XH, Jiang SS, Ye ZZ, Wang J, Gu ZY, Shen HB, Shi KH, Sun SN, Huang GY, Jin L, Wang HY, 2013
- A Functional Variant in the Cystathionine b-Synthase Gene Promoter Significantly Reduces Congenital Heart Disease Susceptibility in Han Chinese Population, Zhao JY, Yang XY, Shi KH, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao Bin, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY, 2013
- A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population, Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B, Wang HY, 2012
- VANGL2 Mutations Identified in Human Cranial Neural-Tube Defects, Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY, 2010
- A Functional SNP in the Promoter of the SERPINH1 Gene Encoding Hsp47 Increases Risk of Preterm Premature Rupture of Membranes and Preterm Birth in African-Americans, Wang H, Parry S, Macones G, Sammel MD, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2006
- Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM), Wang H, Parry S, Macones G, Sammel MD, Ferrand PE, Kuivaniemi H, Tromp G, Halder I, Shriver MD, Romero R, Strauss JF, 2004
- Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China, Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, St Clair D, He L, 2000
Awards
- 2016 - National Maternal and Child Health Science and Technology Award, First Prize in Natural Science: 'Mechanism of New Mutations Causing Birth Defects'
- 2015 - Ministry of Education Natural Science First Prize: 'Genetic Analysis of Major Birth Defects in the Chinese Population'
- 2013 - National May 1st Labor Medal
- 2012 - WuXi AppTec Life Chemistry Outstanding Achievement Award
- 2011 - Tan Jiazhen Life Science Innovation Award
- 2010 - China Young Female Scientist Award
- 2004, 2005, 2006 - President Award, Society for Gynecologic Investigation, USA
