Areas of Focus
- Mesenchymal stem cell in vivo self-renewal, differentiation, and aging regulation mechanisms
- Bone development, bone metabolism, and pathogenesis of osteoporosis
- DNA damage response, aging, and tumor development
Work Experience
- 2001-2009 - Institute of Molecular and Cell Biology, Singapore - PI, Senior PI
- 2009-present - Shanghai Jiao Tong University - Distinguished Professor
Academic Background & Achievements
- Bachelor's Degree: Beijing Normal University
- PhD: Albert Einstein College of Medicine, USA
- Postdoctoral Research: Columbia University
- Recipient of Shanghai 'Pujiang Talent' Program 2009
- Key Project Leader in 863 Program for 'Whole Genome Association Analysis Platform Technology'
Publications
- A positive role for c-Abl in Atm and Atr activation in DNA damage response, Li B et al., 2011
- S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response, Li B et al., 2010
- Atm deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoblastogenesis, Li B et al., 2006
- p53 represses the expression of transcription factor osterix and functions as a negative regulator of osteoblastogenesis and bone formation, Li B et al., 2006
- Distinct roles for c-Abl and Atm in Prx I induction by modulating expression of protein kinase C, Li B et al., 2004
- Activation of p38MAPK is required for osteoblast differentiation, Li B et al., 2003
- c-Abl knockout mice are osteoporotic and show defects in osteoblast maturation, Li B et al., 2000
