2002 - Bachelor's Degree: Zhejiang University, College of Materials and Chemical Engineering
2006 - Master's Degree: Osaka University, Graduate School of Engineering, Molecular Chemistry
2010 - Ph.D.: Kyoto University, Graduate School of Engineering, Synthetic Biochemistry
2011.3-2014.1 - Zhejiang University School of Medicine - Postdoctoral Researcher
2011.6-2014.12 - Zhejiang University School of Medicine - Assistant Researcher
2015.1-2019.12 - Zhejiang University School of Medicine - Associate Researcher
2020.1-Present - Zhejiang University School of Medicine - Researcher
Research
Cancer Nanomedicine Drug Delivery Systems Synthetic Biochemistry Molecular Engineering Photodynamic Therapy Nanoparticle Design Prodrug Development Biomaterials Immunotherapy Translational Medicine
Photoactivatable nanoagonists chemically programmed for pharmacokinetic tuning and in situ cancer vaccination, J. Wan, L. Ren, S. He, Y. Fu, P. Xu, F. Meng, S. Xian, K. Pu, and H. Wang, 2023
A renally clearable activatable polymeric nanoprobe for early detection of hepatic ischemia-reperfusion injury, J. Huang, S. Xian, Y. Liu, X. Chen, K. Pu, and H. Wang, 2022
Targeting the Mitochondria with Pseudo-Stealthy Nanotaxanes to Impair Mitochondrial Biogenesis for Effective Cancer Treatment, L. Ren, P. Xu, J. Yao, Z. Wang, K. Shi, W. Han, and H. Wang, 2022
De novo engineering of both an omega-3 fatty acid-derived nanocarrier host and a prodrug guest to potentiate drug efficacy against colorectal malignancies, X. Chen, L. Cui, S. Xian, F. Meng, C. Zhan, H. Wang, 2022
Tuning the efficacy of esterase-activatable prodrug nanoparticles for the treatment of colorectal malignancies, Y. Wang, H. Xie, B. Xie, X. Chen, B. Yang, J. Jin, J. Wan, T. Li, W. Han, S. Fang, and H. Wang, 2021
Quantitative Self-Assembly of Photoactivatable Small Molecular Prodrug Cocktails for Safe and Potent Cancer Chemo-Photodynamic Therapy, L. Huang, J. Wan, H. Wu, X. Chen, Q. Bian, L. Shi, X. Jiang, A. Yuan, J. Gao, and H. Wang, 2021
Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis, K. Ying, Y. Zhu, J. Wan, C. Zhan, Y. Wang, B. Xie, P. Xu, H. Pan, and H. Wang, 2023
Structure-Guided Engineering of Cytotoxic Cabazitaxel for an Adaptive Nanoparticle Formulation: Enhancing the Drug Safety and Therapeutic Efficacy, J. Wan, Y. Qiao, X. Chen, J. Wu, L. Zhou, J. Zhang, S. Fang and H. Wang, 2018
Target-Oriented Delivery of Self-Assembled Immunosuppressant Cocktails Prolongs Allogeneic Orthotopic Liver Transplant Survival, H. Xie, H. Zhu, K. Zhou, J. Wan, L. Zhang, Z. Yang, L. Zhou, X. Chen, X. Xu, S. Zheng, and H. Wang, 2020
Transforming a Toxic Drug into an Efficacious Nanomedicine Using a Lipoprodrug Strategy for the Treatment of Patient-Derived Melanoma Xenografts, L. Shi, Y. Wang, Q. Wang, Z. Jiang, L. Ren, Y. Yan, Z. Liu, J. Wan, L. Huang, B. Cen, W. Han, and H. Wang, 2020
New Generation Nanomedicines Constructed from Self-Assembling Small Molecule Prodrugs Alleviate Cancer Drug Toxicity, H. Wang, Z. Lu, L. Wang, T. Guo, J. Wu, Z. Li, D. Jiang, P. Song, H. Xie, L. Zhou, X. Xu and S. Zheng, 2017
Antihypertension nanoblockers increase intratumoral perfusion of sequential cytotoxic nanoparticles to enhance chemotherapy efficacy against pancreatic cancer, S. Bian, H. Dong, L. Zhao, Z. Li, J. Chen, X. Zhu, N. Qiu, X. Jia, W. Song, Z. Li, S. Zheng, H. Wang, and P. Song, 2022
Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy, T. Li, W. Shi, J. Yao, J. Hu, Q. Sun, J. Meng, J. Wan, H. Song, and H. Wang, 2022
Ultrasmall organosilica nanoparticles with strong solid-state fluorescence for multifunctional applications, J. Wan, J. Liang, S. Xian, X. Gong, and H. Wang, 2022
Self-assembling a natural small molecular inhibitor that shows aggregation-induced emission and potentiates antitumor efficacy, X. Chen, Z. Hu, L. Zhou, F. Zhang, J. Wan, and H. Wang, 2021
Quantum dots-based hydrogels for sensing applications, J. Zhang, J. Jin, J. Wan, S. Jiang, W. Wang, X. Gong, and H. Wang, 2021
Balancing the stability and drug activation in adaptive nanoparticles potentiates chemotherapy in multidrug-resistant cancer, J. Wan, L. Huang, J. Cheng, F. Huang, J. Jin, and H. Wang, 2021
Photosensitizer-stabilized self-assembling nanoparticles potentiate chemo/photodynamic efficacy of patient-derived melanoma, L. Huang, X. Chen, Q. Bian, F. Zhang, H. Wu, H. Wang, and J. Gao, 2020
Self-assembling prodrugs by precise programming of molecular structures that contribute distinct stability, pharmacokinetics, and antitumor efficacy, H. Wang, H. Xie, J. Wang, J. Wu, X. Ma, L. Li, X. Wei, Q. Ling, P. Song, L. Zhou, X. Xu, and S. Zheng, 2015
Structure-based rational design of prodrugs to enable their combination with polymeric nanoparticle delivery Platforms for enhanced antitumor efficacy, H. Wang, H. Xie, J. Wu, X. Wei, L. Zhou, X. Xu, and S. Zheng, 2014
Chemical cell-surface receptor engineering using affinity-guided, multivalent organocatalysts, H. Wang, Y. Koshi, D. Minato, H. Nonaka, S Kiyonaka, Y. Mori, S. Tsukiji and I. Hamachi, 2011
Self-assembling myristoylated human alpha-defensin 5 as a next-generation nanobiotics potentiates therapeutic efficacy in bacterial infection, R. Lei, J. Hou, Q. Chen, W. Yuan, B. Cheng, Y. Sun, Y. Jin, L. Ge, S. A. Ben-Sasson, H. Wang, W. Lu, X. Fang, 2018
ZNF830 Mediates Cancer Chemoresistance through Promoting Homologous-Recombination Repair, G. Chen, J. Chen, Y. Qiao, Y. Shi, W. Liu, Q. Zeng, X. Shi, Y. Sun, X. Liu, T. Li, L. Zhou, J. Wan, H. Wang and F. Wang, 2018
Orally deliverable nanotherapeutics for the synergistic treatment of colitis-associated colorectal cancer, W. Han, B. Xie, Y. Li, L. Shi, J. Wan, X. Chen and H. Wang, 2019
Polyactide-tethered prodrugs in polymeric nanoparticles as reliable nanomedicines for the efficient eradication of patient-derived hepatocellular carcinoma, H. Wang, L. Zhou, K. Xie, J. Wu, P. Song, H. Xie, L. Zhou, J. Liu, X. Xu, Y. Shen and S. Zheng, 2018
Self-Assembled Gemcitabine Prodrug Nanoparticles Show Enhanced Efficacy against Patient-Derived Pancreatic Ductal Adenocarcinoma, L. Wu, F. Zhang, X. Chen, J. Wan, Y. Wang, T. Li, and H. Wang, 2020
Supramolecular Engineering of Molecular Inhibitors in an Adaptive Cytotoxic Nanoparticle for Synergistic Cancer Therapy, W. Han, L. Shi, B. Xie, J. Wan, L. Ren, Y. Wang, X. Chen and H. Wang, 2020
A general prodrug nanohydrogel platform for reduction-triggered drug activation and treatment of taxane-resistant malignancies, J. Yao, T. Li, X. Shi, Y. Wang, S. Fang, and H. Wang, 2021
Dimerization-Induced Self-Assembly of a Redox-Responsive Prodrug into Nanoparticles for Improved Therapeutic Index, L. Zhou, H. Xie, X. Chen, J. Wan, S. Xu, Y. Han, D. Chen, Y. Qiao, L. Zhou, S. Zheng, and H. Wang, 2020
Preclinical Evaluation of a Cabazitaxel Prodrug Using Nanoparticle Delivery for the Treatment of Taxane-Resistant Malignancies, B. Xie, J. Wan, X. Chen, W. Han and H. Wang, 2020
