2004-2009 PhD in Biochemistry and Molecular Biology: Nanjing Medical University
1999-2004 Bachelor's in Clinical Medicine: Nanjing Medical University
2015 Selected for the National 'Youth Thousand Talents Plan'
2016 Selected for the 'Zhejiang Province Thousand Talents Plan'
2017 Received National 'Excellent Youth Fund'
2016.02– Zhejiang University, School of Medicine, Researcher
2022.04– Zhejiang University Second Affiliated Hospital, Joint Professor
2018.08– Zhejiang University First Affiliated Hospital, Joint Professor
2014.02–2016.01 University of Michigan, Research Investigator
2009.07–2014.01 University of Michigan, Postdoctoral Fellow
2015: National 'Youth Thousand Talents Plan'
2016: 'Zhejiang Province Thousand Talents Plan'
2017: National 'Excellent Youth Fund'
AHA Postdoc Fellowship
AHA SDG Award
Research
Molecular mechanisms and intervention strategies for diabetes Spatiotemporal regulation of glucose and lipid metabolism Chromatin remodeling and type 2 diabetes
Myokines: metabolic regulation in obesity and type 2 diabetes, Chen Z, Weng Z, Lin JD, Meng ZX, 2024
DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition, Lv Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R, Wu Q, Wu L, Meng ZX, Tan M, Li J, 2024
Glutamine production by Glul promotes thermogenic adipocyte differentiation through Prdm9-mediated H3K4me3 and transcriptional reprogramming, Pan X, Ye L, Guo X, Wang W, Zhang Z, Wang Q, Huang J, Xu J, Cai Y, Shou X, Wang Y, Feng Y, Xie C, Shan P, Meng ZX, 2023
The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling, Jin L, Han S, Lv X, Li X, Zhang Z, Kuang H, Chen Z, Lv C, Peng W, Yang Z, Yang M, Mi L, Liu T, Ma S, Qiu X, Wang Q, Pan X, Shan P, Feng Y, Li J, Wang F, Xie L, Zhao X, Fu J, Lin JD, Meng ZX, 2023
Neural innervation in adipose tissue, gut, pancreas, and liver, Sun M, Wan Y, Shi M, Meng ZX, Zeng W, 2023
Myofiber Baf60c controls muscle regeneration by modulating Dkk3-mediated paracrine signaling, Xu J, Li X, Chen W, Zhang Z, Zhou Y, Gou Y, Lv C, Qiu X, Ma S, Wu Q, Liu T, Mi L, Yang Z, Yu T, Pan X, Feng Y, Shan P, Meng ZX, 2023
Integrative profiling of the metabolome and transcriptome in plasma and skeletal muscle following exercise intervention in diet-induced obese mice, Han S, Wu QQ, Wang M, Yang M, Sun C, Liang J, Guo X, Zhang Z, Xu J, Qiu X, Xie C, Chen S, Gao Y, Meng ZX, 2023
β-cell dynamics in type 2 diabetes and in dietary and exercise interventions, Lv C, Sun Y, Zhang ZY, Aboelela Z, Qiu X, Meng ZX, 2022
BAF60a deficiency in macrophage promotes diet-induced obesity and metabolic inflammation, Kong Q, Zou J, Zhang Z, Pan R, Xu Y, Gao Y, Meng ZX, 2022
Comments on ‘Dietary intervention preserves β cell function in mice through CTCF-mediated transcriptional reprogramming.’, Wang RR, Fu H, Li J, Meng ZX, 2022
Dietary Intervention Preserves β-cell Function Through CTCF-mediated Transcriptional Reprogramming, Wang RR, Qiu X, Pan R, Fu H, Wang Q, Zhang Z, Chen H, Wu QQ, Pan X, Wang S, Shan P, Guo G, Zheng M, Zhu L, Meng ZX, 2022
Transcriptional control of pancreatic β-cell identity and plasticity during the pathogenesis of type 2 diabetes, Zhang Z, Gao Y, Meng ZX, 2022
A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion, Qiao J, Zhang Z, Ji S, Liu T, Zhang X, Huang Y, Feng W, Wang K, Wang J, Wang S, Meng ZX, Liu M, 2022
Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx, Yang F, Duan M, Zheng F, Yu L, Wang Y, Wang G, Lin J, Han S, Gan D, Meng Z, Zhu S, 2021
Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice, Wang J, Chen Y, Pan R, Wu Chao, Chen S, Li L, Li Y, Yu C, Meng ZX, Xu C, 2021
The crosstalk between platelets and body fat: A reverse translational study, Han S, Wu P, Duan M, Yang F, He W, Wu N, Hu X, Gan D, Wang G, Yang M, Wang W, Meng ZX, Zhu S, 2021
Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes mellitus, Tang L, Wang H, Dai B, Wang X, Zhou D, Shen J, Guo F, Wang J, Zhou J, Wang H, Wu Q, Yao H, Gong T, Su J, Meng ZX, Niu T, Zhang L, Liang P, 2020
MiR-223 is essential for maintaining functional β-cell mass during diabetes through targeting unique bipartite Foxo1 and Sox6 pathways, Li Y, Deng S, Peng J, Wang X, Essandoh K, Mu X, Peng T, Meng ZX, Fan GC, 2019
The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control, Wang RR, Pan R, Zhang W, Fu J, Lin JD, Meng ZX, 2018
Uncoupling exercise bioenergetics from systemic metabolic homeostasis by conditional inactivation of Baf60s in skeletal muscle, Meng ZX, Tao W, Sun J, Wang Q, Mi L, Lin JD, 2018
Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis, Meng ZX, Gong J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu X.Z.S, Lin JD, 2017
A diet sensitive Baf60a-mediated pathway links bile acid metabolism to atherosclerosis, Meng ZX, Wang L, Chang L, Sun JX, Bao J, Li Y, Chen YE, Lin JD, 2015
The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis, Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD, 2014
The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity, Meng ZX, Wang L, Xiao Y, Lin JD, 2014
Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation, Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Okutsu M, Yan Z, Kim, JK, Lin JD, 2013
A microRNA circuitry links macrophage polarization to metabolic homeostasis, Meng ZX, Wang GX, Lin JD, 2012
Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines, Meng ZX, Yin Y, Lv JH, Sha M, Lin Y, Gao L, Zhu YX, Sun YJ, Han X, 2012
Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction, Meng ZX, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X, 2009
Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest, Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X, 2009
Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction, Meng ZX, Sun JX, Ling JJ, Lv JH, Zhu DY, Chen Q, Sun YJ, Han X, 2006
