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Yingjie Wang
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Cancer Stem Cells
Drug Development
Cell Fate
Molecular Mechanisms
Clinical Applications
Aids
Host Factors
Oct4
Crispr/Cas9
Phosphoinositide Signaling
Areas of Focus
- Basic research on cancer stem cells and new drug development
- Molecular mechanisms of cell fate transformation and clinical applications
- Mechanisms of host factors in AIDS and new drug development
Work Experience
- 1995/07-1997/04 - Hangzhou Gaole Biochemical Products Co., Ltd. - Technician
- 2001/10-2004/10 - UT Southwestern Medical Center - Postdoctoral Researcher
- 2004/11-2009/05 - Merck & Co. - Senior Research Biochemist
- 2009/06–Present - Zhejiang University - Researcher
Academic Background & Achievements
- 1988/09-1992/06 Bachelor: Hangzhou University
- 1992/09-1995/06 Master: Hangzhou University
- 1997/06-2001/08 PhD: Flinders University
- Achievement: Identified core stemness transcription factor Oct4 as a novel anti-cancer stem cell drug target
- Achievement: Revealed the role of Oct4 post-translational modifications in stem cell proliferation and differentiation
- Achievement: Discovered the regulation of cancer stem cell proliferation and differentiation by amino acid metabolites and microenvironment
- Achievement: Found new functions of phosphoinositide signaling molecules in vesicle transport and cell proliferation
Publications
- Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells, Zhou Y, Chen X, Kang B, She S, Zhang X, Chen C, Li W, Chen W, Dan S, Pan X, Liu X, He J, Zhao Q, Zhu C, Peng L, Wang H, Yao H, Cao H, Li L, Herlyn M, Wang YJ, 2018
- Site-specific disruption of the Oct4/Sox2 protein interaction reveals coordinated mesendodermal differentiation and the epithelial-mesenchymal transition, Pan X, Cang X, Dan S, Li J, Cheng J, Kang B, Duan X, Shen B, Wang YJ, 2016
- Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells, Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ, 2015
- Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells, Lin Y, Yang Y, Li W, Chen Q, Li J, Pan X, Zhou L, Liu C, Chen C, He J, Cao H, Yao H, Zheng L, Xu X, Xia Z, Ren J, Xiao L, Li L, Shen B, Zhou H, Wang YJ, 2012
- Critical role of PIP5KIg87 in InsP3-mediated Ca2+ signaling, Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL, 2004
- Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi, Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL, 2003
