Professor | Yingjie Wang | Asia Growth Partners

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Name	Yingjie Wang
Contact Information	yingjiewang@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Yingjie Wang

Contact Information

yingjiewang@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	1988/09-1992/06 Bachelor: Hangzhou University 1992/09-1995/06 Master: Hangzhou University 1997/06-2001/08 PhD: Flinders University Achievement: Identified core stemness transcription factor Oct4 as a novel anti-cancer stem cell drug target Achievement: Revealed the role of Oct4 post-translational modifications in stem cell proliferation and differentiation Achievement: Discovered the regulation of cancer stem cell proliferation and differentiation by amino acid metabolites and microenvironment Achievement: Found new functions of phosphoinositide signaling molecules in vesicle transport and cell proliferation
Work Experience	1995/07-1997/04 - Hangzhou Gaole Biochemical Products Co., Ltd. - Technician 2001/10-2004/10 - UT Southwestern Medical Center - Postdoctoral Researcher 2004/11-2009/05 - Merck & Co. - Senior Research Biochemist 2009/06–Present - Zhejiang University - Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

1988/09-1992/06 Bachelor: Hangzhou University
1992/09-1995/06 Master: Hangzhou University
1997/06-2001/08 PhD: Flinders University
Achievement: Identified core stemness transcription factor Oct4 as a novel anti-cancer stem cell drug target
Achievement: Revealed the role of Oct4 post-translational modifications in stem cell proliferation and differentiation
Achievement: Discovered the regulation of cancer stem cell proliferation and differentiation by amino acid metabolites and microenvironment
Achievement: Found new functions of phosphoinositide signaling molecules in vesicle transport and cell proliferation

Work Experience

1995/07-1997/04 - Hangzhou Gaole Biochemical Products Co., Ltd. - Technician
2001/10-2004/10 - UT Southwestern Medical Center - Postdoctoral Researcher
2004/11-2009/05 - Merck & Co. - Senior Research Biochemist
2009/06–Present - Zhejiang University - Researcher

Areas of Focus	Basic research on cancer stem cells and new drug development Molecular mechanisms of cell fate transformation and clinical applications Mechanisms of host factors in AIDS and new drug development
Publications	Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells, Zhou Y, Chen X, Kang B, She S, Zhang X, Chen C, Li W, Chen W, Dan S, Pan X, Liu X, He J, Zhao Q, Zhu C, Peng L, Wang H, Yao H, Cao H, Li L, Herlyn M, Wang YJ, 2018 Site-specific disruption of the Oct4/Sox2 protein interaction reveals coordinated mesendodermal differentiation and the epithelial-mesenchymal transition, Pan X, Cang X, Dan S, Li J, Cheng J, Kang B, Duan X, Shen B, Wang YJ, 2016 Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells, Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ, 2015 Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells, Lin Y, Yang Y, Li W, Chen Q, Li J, Pan X, Zhou L, Liu C, Chen C, He J, Cao H, Yao H, Zheng L, Xu X, Xia Z, Ren J, Xiao L, Li L, Shen B, Zhou H, Wang YJ, 2012 Critical role of PIP5KIg87 in InsP3-mediated Ca2+ signaling, Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL, 2004 Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi, Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL, 2003

Areas of Focus

Basic research on cancer stem cells and new drug development
Molecular mechanisms of cell fate transformation and clinical applications
Mechanisms of host factors in AIDS and new drug development

Publications

Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells, Zhou Y, Chen X, Kang B, She S, Zhang X, Chen C, Li W, Chen W, Dan S, Pan X, Liu X, He J, Zhao Q, Zhu C, Peng L, Wang H, Yao H, Cao H, Li L, Herlyn M, Wang YJ, 2018
Site-specific disruption of the Oct4/Sox2 protein interaction reveals coordinated mesendodermal differentiation and the epithelial-mesenchymal transition, Pan X, Cang X, Dan S, Li J, Cheng J, Kang B, Duan X, Shen B, Wang YJ, 2016
Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells, Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ, 2015
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells, Lin Y, Yang Y, Li W, Chen Q, Li J, Pan X, Zhou L, Liu C, Chen C, He J, Cao H, Yao H, Zheng L, Xu X, Xia Z, Ren J, Xiao L, Li L, Shen B, Zhou H, Wang YJ, 2012
Critical role of PIP5KIg87 in InsP3-mediated Ca2+ signaling, Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL, 2004
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi, Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL, 2003

Cancer Stem Cells Drug Development Cell Fate Molecular Mechanisms Clinical Applications Aids Host Factors Oct4 Crispr/Cas9 Phosphoinositide Signaling

Dawei Huo - Zhejiang University

Hui Lin - Zhejiang University

Hangping Yao - Zhejiang University

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