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Yu Xiong Feng
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Tumor
Metastasis
Molecular Mechanisms
Cellular Metabolism
Stress
Drug Resistance
3D Model
Normal Tissue
Tumor Tissue
Clinical Application
Areas of Focus
- Molecular Mechanisms of Tumor Metastasis
- Role of Cellular Metabolism and Stress in Tumor Drug Resistance
- Construction and Clinical Application of 'Normal Tissue-Tumor Tissue' 3D Co-evolution Model
Work Experience
- 2018-present - Zhejiang University Translational Medicine Institute/Zhejiang University First Affiliated Hospital - Researcher/Joint Professor
- 2010-2017 - Massachusetts Institute of Technology - Postdoctoral Researcher
Academic Background & Achievements
- 2004-2010 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2000-2004 Bachelor's in Biotechnology: College of Life Sciences, Zhejiang University
- Core Member of Zhejiang Provincial Leading Innovation Team
- Selected for the National Overseas High-Level Talent Program
Publications
- Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth, Zhao JS, Shi S, Qu HY, et al., Liang T, Lu Z, Feng YX, 2022
- Transcriptional Control of Metastasis by Integrated Stress Response Signaling, Lu S, Yang LX, Cao ZJ, Zhao JS, You J, Feng YX, 2021
- Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells, Feng M, Jin JQ, Xia L, et al., Feng YX, Zhu D, 2019
- Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1, Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB, 2017
- SMARCE1 is required for the invasive progression of in situ cancers, Sokol ES, Feng YX, Jin DX, Tizabi MD, Miller DH, et al., 2017
- Epithelial-to-mesenchymal transition activates PERK-eIF2alpha and sensitizes cells to endoplasmic reticulum stress, Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, et al., 2014
- The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition, Feng YX, Sokol ES, Gupta PB, 2014
- Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model, Feng YX, Wang T, Deng YZ, Yang P, Li JJ, et al., 2011
- Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway, Feng YX, Zhao JS, Li JJ, Wang T, Cheng SQ, et al., 2010
