Professor | Hangping Yao | Asia Growth Partners

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Name	Hangping Yao
Contact Information	yaohangping@zju.edu.cn
Language ability	Chinese, German
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Hangping Yao

Contact Information

yaohangping@zju.edu.cn

Language ability

Chinese, German

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2004-2007: Visiting Scholar at Ruhr University and University of Vienna Isolated and identified H7N9 avian influenza virus Developed China's first H7N9 vaccine seed strain Received the 2017 National Science and Technology Progress Award Special Prize
Work Experience	2004-2007 - Ruhr University and University of Vienna - Visiting Scholar Researcher at Zhejiang University National Key Laboratory for Diagnosis and Treatment of Infectious Diseases
Awards	National Science and Technology Progress Award Special Prize (2017): Major innovations and technological breakthroughs in the prevention and control system of emerging infectious diseases represented by human infection with H7N9 avian influenza Zhejiang Provincial Science and Technology Progress Award Second Prize (2017): Research on the diagnosis and treatment of Ebola virus disease in West Africa Chinese Medical Science Award First Prize (2015): Theoretical innovation and technological breakthrough in the diagnosis and treatment of human infection with H7N9 avian influenza National Science and Technology Progress Award First Prize (2013): Theoretical innovation and technological breakthrough in the diagnosis and treatment of severe liver disease

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2004-2007: Visiting Scholar at Ruhr University and University of Vienna
Isolated and identified H7N9 avian influenza virus
Developed China's first H7N9 vaccine seed strain
Received the 2017 National Science and Technology Progress Award Special Prize

Work Experience

2004-2007 - Ruhr University and University of Vienna - Visiting Scholar
Researcher at Zhejiang University National Key Laboratory for Diagnosis and Treatment of Infectious Diseases

Awards

National Science and Technology Progress Award Special Prize (2017): Major innovations and technological breakthroughs in the prevention and control system of emerging infectious diseases represented by human infection with H7N9 avian influenza
Zhejiang Provincial Science and Technology Progress Award Second Prize (2017): Research on the diagnosis and treatment of Ebola virus disease in West Africa
Chinese Medical Science Award First Prize (2015): Theoretical innovation and technological breakthrough in the diagnosis and treatment of human infection with H7N9 avian influenza
National Science and Technology Progress Award First Prize (2013): Theoretical innovation and technological breakthrough in the diagnosis and treatment of severe liver disease

Areas of Focus	Infectious Diseases Infection and Cancer Tumor Biology and Targeted Therapy Preclinical Research of Antibodies and Antibody Drugs
Publications	RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE, Suthe SR, Yao HP, Weng TH, Hu CY, Feng L, Wu ZG, Wang MH, 2018 Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase, Yao HP, Feng L, Weng TH, Hu CY, Suthe SR, Mostofa AGM, Chen LH, Wu ZG, Wang WL, Wang MH, 2018 Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements, Yu DS, Weng TH, Hu CY, Wu ZG, Li YH, Cheng LF, Wu NP, Li LJ, Yao HP, 2018 Preparation of immunochromatographic strips for rapid detection of early secreted protein ESAT-6 and culture filtrate protein CFP-10 from Mycobacterium tuberculosis, Wu X, Wang Y, Weng T, Hu C, Wang FXC, Wu Z, Yu D, Lu H, Yao H, 2017 MicroRNA expression profiling of pancreatic cancer cell line L3.6p1 following B7-H4 knockdown, Qian Y, Feng L, Wu W, Weng T, Hu C, Hong B, Wang FXC, Shen L, Wang Q, Jin X, Yao H, 2017 B7-H4 is a prognostic biomarker for poor survival in patients with pancreatic cancer, Shen L, Qian Y, Wu W, Weng T, Wang FXC, Hong B, Wu Z, Wang Q, Sang Y, Zhang H, Zhou X, Yao H, 2017 Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine, Ou H, Yao W, Wu N, Wang FX, Weng T, Han C, Lu X, Yu D, Wu H, Cheng L, Chen H, Yao H, Li L, 2016 Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases, Qian Y, Sang Y, Wang FX, Hong B, Wang Q, Zhou X, Weng T, Wu Z, Zheng M, Zhang H, Yao H, 2016 HIV-1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF-κB pathway, Feng T, Gan J, Qin A, Huang X, Wu N, Hu H, Yao H, 2016 Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment, Yao HP, Feng L, Zhou JW, Zhang RW, Wang MH, 2016 Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer, Feng L, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2016 Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in BALB/c mice, Ou H, Yao H, Yao W, Wu N, Wu X, Han C, Cheng L, Chen K, Chen H, Li L, 2016 Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma, Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP, 2016 Efficacy of Anti-RON Antibody Zt/g4-Drug Maytansinoid Conjugation (Anti-RON ADC) as a Novel Therapeutics for Targeted Colorectal Cancer Therapy, Feng L, Yao HP, Wang W, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014 Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics, Sharma S, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014 Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells, Zeng JY, Sharma S, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2014 Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY, 2013 Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study, Yang S, Chen Y, Cui D, Yao H, Lou J, Huo Z, Xie G, Yu F, Zheng S, Yang Y, Zhu Y, Lu X, Liu X, Lau SY, Chan JF, To KK, Yuen KY, Chen H, Li L, 2014 Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A (H7N9) virus, Yu L, Wang Z, Chen Y, Ding W, Jia H, Chan JF, To KK, Chen H, Yang Y, Liang W, Zheng S, Yao H, Yang S, Cao H, Dai X, Zhao H, Li J, Bao Q, Chen P, Hou X, Li L, Yuen KY, 2013 MSP-RON signalling in cancer: pathogenesis and therapeutic potential, Yao HP, Zhou YQ, Zhang R, Wang MH, 2013 B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells, Qian Y, Hong B, Shen L, Wu Z, Yao H, Zhang L, 2013 Oncogenic Variant RON160 Expression in Breast Cancer and its Potential as a Therapeutic Target by Small Molecule Tyrosine Kinase Inhibitor, Yao HP, Zhuang CM, Zhou YQ, Zeng JY, Zhang RW, Wang MH, 2013 Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents, Sharma S, Zeng JY, Zhuang CM, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2013 The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on

Areas of Focus

Infectious Diseases
Infection and Cancer
Tumor Biology and Targeted Therapy
Preclinical Research of Antibodies and Antibody Drugs

Publications

RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE, Suthe SR, Yao HP, Weng TH, Hu CY, Feng L, Wu ZG, Wang MH, 2018
Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase, Yao HP, Feng L, Weng TH, Hu CY, Suthe SR, Mostofa AGM, Chen LH, Wu ZG, Wang WL, Wang MH, 2018
Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements, Yu DS, Weng TH, Hu CY, Wu ZG, Li YH, Cheng LF, Wu NP, Li LJ, Yao HP, 2018
Preparation of immunochromatographic strips for rapid detection of early secreted protein ESAT-6 and culture filtrate protein CFP-10 from Mycobacterium tuberculosis, Wu X, Wang Y, Weng T, Hu C, Wang FXC, Wu Z, Yu D, Lu H, Yao H, 2017
MicroRNA expression profiling of pancreatic cancer cell line L3.6p1 following B7-H4 knockdown, Qian Y, Feng L, Wu W, Weng T, Hu C, Hong B, Wang FXC, Shen L, Wang Q, Jin X, Yao H, 2017
B7-H4 is a prognostic biomarker for poor survival in patients with pancreatic cancer, Shen L, Qian Y, Wu W, Weng T, Wang FXC, Hong B, Wu Z, Wang Q, Sang Y, Zhang H, Zhou X, Yao H, 2017
Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine, Ou H, Yao W, Wu N, Wang FX, Weng T, Han C, Lu X, Yu D, Wu H, Cheng L, Chen H, Yao H, Li L, 2016
Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases, Qian Y, Sang Y, Wang FX, Hong B, Wang Q, Zhou X, Weng T, Wu Z, Zheng M, Zhang H, Yao H, 2016
HIV-1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF-κB pathway, Feng T, Gan J, Qin A, Huang X, Wu N, Hu H, Yao H, 2016
Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment, Yao HP, Feng L, Zhou JW, Zhang RW, Wang MH, 2016
Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer, Feng L, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2016
Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in BALB/c mice, Ou H, Yao H, Yao W, Wu N, Wu X, Han C, Cheng L, Chen K, Chen H, Li L, 2016
Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma, Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP, 2016
Efficacy of Anti-RON Antibody Zt/g4-Drug Maytansinoid Conjugation (Anti-RON ADC) as a Novel Therapeutics for Targeted Colorectal Cancer Therapy, Feng L, Yao HP, Wang W, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics, Sharma S, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014
Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells, Zeng JY, Sharma S, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2014
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY, 2013
Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study, Yang S, Chen Y, Cui D, Yao H, Lou J, Huo Z, Xie G, Yu F, Zheng S, Yang Y, Zhu Y, Lu X, Liu X, Lau SY, Chan JF, To KK, Yuen KY, Chen H, Li L, 2014
Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A (H7N9) virus, Yu L, Wang Z, Chen Y, Ding W, Jia H, Chan JF, To KK, Chen H, Yang Y, Liang W, Zheng S, Yao H, Yang S, Cao H, Dai X, Zhao H, Li J, Bao Q, Chen P, Hou X, Li L, Yuen KY, 2013
MSP-RON signalling in cancer: pathogenesis and therapeutic potential, Yao HP, Zhou YQ, Zhang R, Wang MH, 2013
B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells, Qian Y, Hong B, Shen L, Wu Z, Yao H, Zhang L, 2013
Oncogenic Variant RON160 Expression in Breast Cancer and its Potential as a Therapeutic Target by Small Molecule Tyrosine Kinase Inhibitor, Yao HP, Zhuang CM, Zhou YQ, Zeng JY, Zhang RW, Wang MH, 2013
Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents, Sharma S, Zeng JY, Zhuang CM, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2013
The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on

Infectious Diseases: Infection Immunity Pathogens Rapid Identification H7N9 Avian Influenza Vaccine Public Health Outbreak Control Infection And Cancer: Infection Cancer Immune Response Tumor Microenvironment Oncogenesis Chronic Infection Viral Oncogenesis Bacterial Oncogenesis Inflammation Therapy Tumor Biology And Targeted Therapy: Tumor Biology Targeted Therapy Ron Receptor Monoclonal Antibodies Immunohistochemistry Prognosis Molecular Mechanisms Drug Targets Cancer Treatment Preclinical Research Of Antibodies And Antibody Drugs: Antibodies Preclinical Research Drug Development Adc Efficacy Safety Cancer Therapy Humanized Antibodies Clinical Application

Linrong Lu - Zhejiang University

Qingqing Wang - Zhejiang University

Songmin Ying - Zhejiang University

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