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Hangping Yao
Medical School
Zhejiang University
Zhejiang
Language: Chinese, German
Infectious Diseases: Infection
Immunity
Pathogens
Rapid Identification
H7N9
Avian Influenza
Vaccine
Public Health
Outbreak
Control
Infection And Cancer: Infection
Cancer
Immune Response
Tumor Microenvironment
Oncogenesis
Chronic Infection
Viral Oncogenesis
Bacterial Oncogenesis
Inflammation
Therapy
Tumor Biology And Targeted Therapy: Tumor
Biology
Targeted Therapy
Ron Receptor
Monoclonal Antibodies
Immunohistochemistry
Prognosis
Molecular Mechanisms
Drug Targets
Cancer Treatment
Preclinical Research Of Antibodies And Antibody Drugs: Antibodies
Preclinical Research
Drug Development
Adc
Efficacy
Safety
Cancer Therapy
Humanized Antibodies
Clinical Application
Areas of Focus
- Infectious Diseases
- Infection and Cancer
- Tumor Biology and Targeted Therapy
- Preclinical Research of Antibodies and Antibody Drugs
Work Experience
- 2004-2007 - Ruhr University and University of Vienna - Visiting Scholar
- Researcher at Zhejiang University National Key Laboratory for Diagnosis and Treatment of Infectious Diseases
Academic Background & Achievements
- 2004-2007: Visiting Scholar at Ruhr University and University of Vienna
- Isolated and identified H7N9 avian influenza virus
- Developed China's first H7N9 vaccine seed strain
- Received the 2017 National Science and Technology Progress Award Special Prize
Publications
- RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE, Suthe SR, Yao HP, Weng TH, Hu CY, Feng L, Wu ZG, Wang MH, 2018
- Preclinical Efficacy of Anti-RON Antibody-Drug Conjugate Zt/g4-MMAE for Targeted Therapy of Pancreatic Cancer Overexpressing RON Receptor Tyrosine Kinase, Yao HP, Feng L, Weng TH, Hu CY, Suthe SR, Mostofa AGM, Chen LH, Wu ZG, Wang WL, Wang MH, 2018
- Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements, Yu DS, Weng TH, Hu CY, Wu ZG, Li YH, Cheng LF, Wu NP, Li LJ, Yao HP, 2018
- Preparation of immunochromatographic strips for rapid detection of early secreted protein ESAT-6 and culture filtrate protein CFP-10 from Mycobacterium tuberculosis, Wu X, Wang Y, Weng T, Hu C, Wang FXC, Wu Z, Yu D, Lu H, Yao H, 2017
- MicroRNA expression profiling of pancreatic cancer cell line L3.6p1 following B7-H4 knockdown, Qian Y, Feng L, Wu W, Weng T, Hu C, Hong B, Wang FXC, Shen L, Wang Q, Jin X, Yao H, 2017
- B7-H4 is a prognostic biomarker for poor survival in patients with pancreatic cancer, Shen L, Qian Y, Wu W, Weng T, Wang FXC, Hong B, Wu Z, Wang Q, Sang Y, Zhang H, Zhou X, Yao H, 2017
- Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine, Ou H, Yao W, Wu N, Wang FX, Weng T, Han C, Lu X, Yu D, Wu H, Cheng L, Chen H, Yao H, Li L, 2016
- Prognostic significance of B7-H4 expression in matched primary pancreatic cancer and liver metastases, Qian Y, Sang Y, Wang FX, Hong B, Wang Q, Zhou X, Weng T, Wu Z, Zheng M, Zhang H, Yao H, 2016
- HIV-1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF-κB pathway, Feng T, Gan J, Qin A, Huang X, Wu N, Hu H, Yao H, 2016
- Therapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment, Yao HP, Feng L, Zhou JW, Zhang RW, Wang MH, 2016
- Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer, Feng L, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2016
- Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in BALB/c mice, Ou H, Yao H, Yao W, Wu N, Wu X, Han C, Cheng L, Chen K, Chen H, Li L, 2016
- Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma, Hong B, Qian Y, Zhang H, Sang YW, Cheng LF, Wang Q, Gao S, Zheng M, Yao HP, 2016
- Efficacy of Anti-RON Antibody Zt/g4-Drug Maytansinoid Conjugation (Anti-RON ADC) as a Novel Therapeutics for Targeted Colorectal Cancer Therapy, Feng L, Yao HP, Wang W, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014
- Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics, Sharma S, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH, 2014
- Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells, Zeng JY, Sharma S, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2014
- Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome, Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY, 2013
- Avian-origin H7N9 virus infection in H7N9-affected areas of China: a serological study, Yang S, Chen Y, Cui D, Yao H, Lou J, Huo Z, Xie G, Yu F, Zheng S, Yang Y, Zhu Y, Lu X, Liu X, Lau SY, Chan JF, To KK, Yuen KY, Chen H, Li L, 2014
- Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A (H7N9) virus, Yu L, Wang Z, Chen Y, Ding W, Jia H, Chan JF, To KK, Chen H, Yang Y, Liang W, Zheng S, Yao H, Yang S, Cao H, Dai X, Zhao H, Li J, Bao Q, Chen P, Hou X, Li L, Yuen KY, 2013
- MSP-RON signalling in cancer: pathogenesis and therapeutic potential, Yao HP, Zhou YQ, Zhang R, Wang MH, 2013
- B7-H4 enhances oncogenicity and inhibits apoptosis in pancreatic cancer cells, Qian Y, Hong B, Shen L, Wu Z, Yao H, Zhang L, 2013
- Oncogenic Variant RON160 Expression in Breast Cancer and its Potential as a Therapeutic Target by Small Molecule Tyrosine Kinase Inhibitor, Yao HP, Zhuang CM, Zhou YQ, Zeng JY, Zhang RW, Wang MH, 2013
- Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents, Sharma S, Zeng JY, Zhuang CM, Zhou YQ, Yao HP, Hu X, Zhang R, Wang MH, 2013
- The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on
Awards
- National Science and Technology Progress Award Special Prize (2017): Major innovations and technological breakthroughs in the prevention and control system of emerging infectious diseases represented by human infection with H7N9 avian influenza
- Zhejiang Provincial Science and Technology Progress Award Second Prize (2017): Research on the diagnosis and treatment of Ebola virus disease in West Africa
- Chinese Medical Science Award First Prize (2015): Theoretical innovation and technological breakthrough in the diagnosis and treatment of human infection with H7N9 avian influenza
- National Science and Technology Progress Award First Prize (2013): Theoretical innovation and technological breakthrough in the diagnosis and treatment of severe liver disease
