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Gensheng Zhang
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Acute Kidney Injury
Chronic Kidney Disease
Cisplatin
Sepsis
Ischemia-Reperfusion
Diabetic Nephropathy
Small Molecule Drugs
Kidney Injury
Pharmacology
Efficacy
Areas of Focus
- Mechanisms of acute and chronic kidney disease induced by cisplatin, sepsis, and ischemia-reperfusion
- Mechanisms of diabetic nephropathy
- Efficacy and pharmacology of small molecule drugs in improving kidney injury
Work Experience
- 2021.07 - Zhejiang University School of Medicine Affiliated Children's Hospital - Associate Researcher
- 2022.11 - Zhejiang University School of Medicine Affiliated Children's Hospital - Executive Director of Children's Kidney and Urology Research Center
Publications
- Dihydromyricetin alleviates cisplatin-induced kidney injury by reducing mitochondria-mediated apoptosis via the EGFR/HSP27/STAT3 signaling pathway., Xu Z, Zhang M, Zhang X, Han H, Ye W, Chen Z, Lv Z, Liu Y, Liu Z, Gong J, Zhu B, Zhou S, Lai EY, Zhu R, Tao C, Zhang G, Yan X., 2023
- Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis., Xu Z, Zhang M, Wang W, Zhou S, Yu M, Qiu X, Jiang S, Wang X, Tang C, Li S, Wang CH, Zhu R, Peng WX, Zhao L, Fu X, Patzak A., Persson PB., Zhao L, Mao J, Shu Q, Lai EY, Zhang G., 2023
- Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney., Zhang G, Han H, Zhuge Z, Dong F, Jiang S, Wang W, Guimarães DD., Schiffer TA., Lai EY, Ribeiro Antonino Carvalho LR, Lucena RB, Braga VA., Weitzberg E., Lundberg JO., Carlstrom M., 2021
- Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function., Yoshida S, Wei X, Zhang G, O'Connor CL., Torres M, Zhou Z, Lin L, Menon R, Xu Xiaoxi, Zheng W, Xiong Y, Otto E, Tang CHA., Hua R, Verma R, Mori Hi, Zhang Y, Hu CCA, Liu M, Garg P, Hodgin JB., Sun S, Bitzer M, Qi L., 2021
- Tempol protects against acute renal injury by regulating PI3K/Akt/mTOR and GSK3β signaling cascades and afferent arteriolar activity., Zhang G, Wang Q, Wang W, Yu M, Zhang S, Xu N, Zhou S, Cao X, Fu X, Ma Z, Liu R, Mao J, Lai EY., 2018
- Protective effect of tempol on acute kidney injury through PI3K/Akt/Nrf2 signaling pathway., Zhang G, Wang Q, Zhou Q, Wang R, Xu M, Wang H, Wang L, Wilcox CS., Liu R, Lai EY., 2016
- The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia., Zhang GS, Tian Y, Huang JY, Tao RR, Liao MH, Lu YM, Ye WF, Wang R, Fukunaga K, Lou YJ, Han F., 2013
- Expression profiling of Ca2+/calmodulin-dependent signaling molecules in the rat dorsal and ventral hippocampus after acute lead exposure., Zhang GS, Ye WF, Tao RR, Lu YM, Shen GF, Fukunaga K, Huang JY, Ji YL, Han F., 2012
- NO-ferroheme is a signaling entity in the vasculature., Kleschyov AL., Zhuge Z, Schiffer TA., Guimarães DD., Zhang G, Montenegro MF., Tesse A, Weitzberg E, Carlström M, and Lundberg JO., 2023
- TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy., Yu B, Jin L, Yao Y, Zhang Y, Zhang G, Wang F, Su X, Fang Q, Xiao L, Yang Y, Jiang LH, Chen J, Yang W, Lin W, Han F., 2023
- Dihydromyricetin functions as a tumor suppressor in hepatoblastoma by regulating SOD1/ROS pathway., Guo T, Wang X, Zhang G, Xia T, Zhu R, Tou J., 2023
- Mifepristone increases AQP1 mRNA expression, angiogenesis, and cell permeability through the ERK MAPK pathway., Wang W, Kang Y, Jiang Y, Zhuang Y, Zhang G, Chen Y, Zhou F., 2023
- Tacrolimus causes hypertension by increasing vascular contractility via RhoA/ROCK pathway in mice., Wang X, Jiang S, Fei L, Dong F, Xie L, Qiu X, Lei Y, Guo J, Zhong M, Ren X, Yang Y, Zhao L, Zhang G, Wang H, Tang C, Yu L Liu R, Patzak A, Persson P B., Hultström M, Wei Q, Lai EY, Zheng Z., 2022
- The obligatory role of host microbiota in bioactivation of dietary nitrate., Moretti C, Zhuge Z, Zhang G, Haworth SM, Paulo LL, Guimarães DD, Cruz JC, Montenegro MF, Cordero-Herrera I, Braga VA, Weitzberg E, Carlström M, Lundberg JO., 2019
- NaHCO3 Dilates Mouse Afferent Arteriole Via Na +/HCO 3- Cotransporters NBCs., Jiang S, Wang X, Wei J, Zhang G, Zhang J, Xie P, Xu L, Wang L, Zhao L, Li L, Wilcox CS, Chen J, Lai EY, Liu R., 2019
- ADAMTS13 protects mice against renal ischemia/reperfusion injury by reducing inflammation and improving endothelial function., Zhou S, Jiang S, Guo J, Xu N, Wang Q, Zhang G, Zhao L, Zhou Q, Fu X, Li L, Patzak A, Hultström M, Lai EY., 2019
- The role of intratubular pressure during the ischemic phase in acute kidney injury., Wei J, Song J, Jiang S, Zhang G, Wheeler D, Zhang J, Wang S, Lai EY, Wang L, Buggs J, Liu R., 2017
- A new mouse model of hemorrhagic shock-induced acute kidney injury., Wang L, Song J, Buggs J, Wei Jin, Wang S, Zhang J, Zhang G, Lu Y, Yip KP, Liu R., 2017
- Inhibition of NOS1 induces salt-sensitive hypertension in NOS1α knockout and wild type mice., Wang X, Chandrashekar K, Wang L, Lai EY, Wei J, Zhang G, Wang S, Zhang J, Juncos LA., Liu R., 2016
- The Disturbance of Hippocampal CaMKII/PKA/PKC Phosphorylation in Early Experimental Diabetes Mellitus., Liao MH, Xiang YC, Huang JY, Tao RR, Tian Y, Ye WF, Zhang GS, Lu YM, Ahmed MM., Liu ZR, Fukunaga K, Han F., 2013
- PET demonstrates functional recovery after transplantation of induced pluripotent stem cells in a rat model of cerebral ischemic injury., Wang J, Chao F, Han F, Zhang G, Xi Q, Li Ji, Jiang H, Wang J, Yu G, Tian M, Zhang H., 2013
- Effect of chronic lead exposure on expression of autophagy-associated proteins in rat hippocampus., Ye WF, Tian Y, Huang JY, Liao MH, Tao RR, Zhang GS, Lou YJ, Han F., 2012
- Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells., Han F, Chen YX, Lu YM, Huang JY, Zhang GS, Tao RR, Ji YL, Liao MH, Fukunaga K, Qin ZH., 2011
- Melatonin ameliorates ischemic- like injury-evoked nitrosative stress: involvement of HtrA2/PED pathways in endothelial cells., Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH., 2011
