2007 - Bachelor's Degree: Zhejiang University, College of Animal Sciences
2012 - PhD: Zhejiang University, College of Animal Sciences
Postdoctoral Research: Harvard Medical School
Published over 20 SCI papers in international journals
Principal Investigator of 8 research projects funded by various foundations
Recipient of Zhejiang Provincial Natural Science First Prize
2020-Present - Zhejiang University School of Medicine, Affiliated Children's Hospital - Distinguished Researcher, Executive Director of the Children's Cancer Research Center
Postdoctoral Research - Harvard Medical School
Zhejiang Provincial Natural Science First Prize
Research
Mechanisms of pediatric solid tumors Animal models for pediatric tumors New technologies for precise diagnosis and treatment of pediatric tumors Neural crest development
Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients, He M, Cai J, Wu X, Tang Y, Wang J, Mao J, Chen J, Zhang L, Guan Z, Xiong J, Peng W, Wang J, Tao T., 2023
Targeting ganglioneuromas with mTOR inhibitors, Tao T, Shi H, Durbin AD, Look AT., 2021
LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors, Tao T, Shi H, Mariani L, Abraham BJ, Durbin AD, Zimmerman MW, Powers JT, Missios P, Ross KN, Perez-Atayde AR, Bulyk ML, Young RA, Daley GQ, Look AT., 2020
Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors, Tao T, Shi H, Wang M, Perez-Atayde AR, London WB, Gutierrez A, Lemos B, Durbin AD, Look AT., 2020
ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression, Shi H, Tao T, Abraham BJ, Durbin AD, Zimmerman MW, Kadoch C, Look AT., 2020
Loss of ATRX cooperates with p53-Deficiency to promote the development of sarcomas and other malignancies, Oppel F, Tao T, Shi H, Ross KN, Zimmerman MW, He S, Tong G, Aster JC, Look AT., 2019
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma, Tao T, Sondalle SB, Shi H, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look AT., 2017
Def defines a nucleolar pathway that leading p53 to proteasome-independent degradation, Tao T, Shi H, Guan Y, Huang D, Chen Y, Lane DP, Chen J, Peng J., 2013
Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish, Tao T, Shi H, Huang D, Peng J., 2013
Liver development in zebrafish (Danio rerio), Tao T, Peng J., 2009
Expression of Apalbumin1 of Apis cerana cerana in the larvae of silkworm, Bombyx mori, Tao T, Su S, Miao Y, Yue W, Du H, Chen S, Liu F, Zhan Y., 2008
Progress in preclinical models of pediatric rhabdomyosarcoma, Hu Y, Tao T, Liu S, He Z, Wang J., 2023
Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state, Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT., 2023
Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma but can be subverted by enhancer hijacking of MYC or MYCN, Zimmerman MW, Durbin AD, He S, Oppel F, Shi H, Tao T, Li Z, Berezovskaya A, Liu Y, Zhang J, Young RA, Abraham BJ, Look AT., 2021
Metabolic enzyme DLST promotes tumor aggression and reveals a vulnerability to OXPHOS inhibition in high-risk neuroblastoma, Anderson NM, Qin X, Finan JM, Lam A, Athoe J, Missiaen R, Skuli N, Kennedy A, Saini AS, Tao T, Zhu S, Nissim I, Look AT, Qing G, Simon MC, Feng H., 2021
GAS7 deficiency promotes metastasis in MYCN-driven neuroblastoma, Dong Z, Yeo KS, Lopez G, Zhang C, Dankert Eggum EN, Rokita JL, Ung CY, Levee TM, Her ZP, Howe CJ, Hou X, van Ree JH, Li S, He S, Tao T, Fritchie K, Torres-Mora J, Lehman JS, Meves A, Razidlo GL, Rathi KS, Weroha SJ, Look AT, van Deursen JM, Li H, Westendorf JJ, Maris JM and Zhu S., 2021
suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma, Oppel F, Ki DH, Zimmermann MW, Ross KN, Tao T, Shi H, He S, Aster JC, Look AT., 2020
LMO1 synergizes with MYCN to promote neuroblastoma initiation and metastasis, Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT., 2017
Critical role for GAB2 in neuroblastoma pathogenesis through the promotion of SHP2/MYCN cooperation, Zhang X, Dong Z, Zhang C, Ung CY, He S, Tao T, Oliveira AM, Meves A, Ji B, Look AT, Li H, Neel BG, Zhu S., 2017
Phosphorylation of Def regulates nucleolar p53 turnover and cell-cycle progression through Def recruitment of Calpain3, Guan Y, Huang D, Chen F, Gao C, Tao T, Shi H, Zhao S, Liao Z, Lo L, Wang Y, Chen J, Peng J., 2016
A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function, Shi H, Tao T, Huang D, Ou Z, Chen J, Peng J., 2015
p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage, Gong L, Gong H, Pan X, Chang C, Ou Z, Ye S, Yin L, Yang L, Tao T, Zhang Z, Liu C, Lane DP, Peng J, Chen J., 2015
The expression of Glia Maturation Factors and the effect of Glia Maturation Factor-γ on angiogenic sprouting in Zebrafish, Zuo P, Fu Z., Tao T, Ye F, Chen L, Wang X, Lu W, Xie X., 2013
Area of Focus
Cell Biology | Molecular Biology | Signal Transduction | Cancer | Immunotherapy | Oral Diseases | Tumor Microenvironment | Clinical Samples | Animal Models | Drug Development
