{'en': 'deqiangs at zju dot edu dot cn', 'zh': 'deqiangs at zju dot edu dot cn', 'de': 'deqiangs at zju dot edu dot cn'}
Chinese, English
Zhejiang
Academic Information
Zhejiang University
Medical
Bachelor's Degree in Physics: Nanjing University
Ph.D. in Physics: Texas A&M University
Postdoctoral in Bioinformatics: Baylor College of Medicine
Tenure-track Assistant Professor: Baylor College of Medicine
National-level talent program support
Research
Bioinformatics Deep Learning DNA Methylation Single-cell Methylation Cancer Early Detection Chronic Disease Detection
Bottomonium production at root s(NN)=200 GeV and root s(NN)=5.5 TeV, Grandchamp L, Lumpkins S, Sun D, van Hees H, Rapp R, 2006
Fast quantum noise in the Landau-Zener transition, Pokrovsky VL, Sun D, 2007
Molecular production at a broad Feshbach resonance in a Fermi gas of cooled atoms, Sun D, Abanov A, Pokrovsky VL, 2008
Landau-Zener transitions in noisy environment and many-body systems, Sun D, 2010
Research resource: The estrogen receptor alpha cistrome defined by DamIP, Xiao R, Sun D, Ayers S, Xi Y, Li W, Baxter JD, Moore DD, 2012
RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing, Xi Y, Bock C, Muller F, Sun D, Meissner A, Li W, 2012
Dnmt3a is essential for hematopoietic stem cell differentiation, Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y et al., 2012
Sexually dimorphic genome-wide binding of retinoid X receptor alpha (RXRalpha) determines male-female differences in the expression of hepatic lipid processing genes in mice, Kosters A, Sun D, Wu H, Tian F, Felix JC, Li W, Karpen SJ, 2013
BSeQC: quality control of bisulfite sequencing experiments, Lin X, Sun D, Rodriguez B, Zhao Q, Sun H, Zhang Y, Li W, 2013
Large conserved domains of low DNA methylation maintained by Dnmt3a, Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R et al., 2013
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal, Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R et al., 2014
MOABS: model based analysis of bisulfite sequencing data, Sun D, Xi Y, Rodriguez B, Park HJ, Tong P, Meong M, Goodell MA, Li W, 2014
Dnmt3a and Dnmt3b Have Overlapping and Distinct Functions in Hematopoietic Stem Cells, Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z et al., 2014
Long Non-Coding RNAs Control Hematopoietic Stem Cell Function, Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA, 2015
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells, Johnson G, Li J, Beaver L, Dashwood W, Sun D, Rajendran P, Williams D, Ho E, Dashwood R, 2016
Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation, Matatall K, Jeong M, Chen S, Sun D, Chen F, Mo Q, Kimmel M, King KY, 2016
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam, Ertem FU, Zhang W, Chang K, Dashwood W, Rajendran P, Sun D, Abudayyeh A, Vilar E, Abdelrahim M, Dashwood RH, 2017
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling, Lee M, Li J, Liang Li, Ma G, Zhang J, He L, Liu Y, Li Q, Li M, Sun D, Zhou Y, Huang Y, 2017
Mutational cooperativity of TET2 and RHOA disrupts peripheral T-cell homeostasis, Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Yang Y, Zhou Y, Rao A, You M, Sun D, Huang Y, 2017
Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC, Li J, Wu X, Zhou Y, Lee M, Guo L, Han W, Mo W, Cao W, Sun D, Xie R, Huang Y, 2018
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition, Cai Y, Huang G, Ma L, Dong L, Chen S, Shen X, Zhang S, Xue R, Sun D, Zhang S, 2018
ZRANB1 is an EZH2 deubiquitinase and a potential therapeutic target in breast cancer, Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton B, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon S, Siverly A, Su X, Li J, Xie X, Cheng X, Liu L, Chang H, Chiang S, Lopez-Berestein G, Sood A, Chen J, You J, Sun D, Sun Y, Hung M, Ma L, 2018
DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells, Gu T, Lin X, Cullen S, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi L, Chen J, Kyba M, Huang Y, Chen T, Li W, Goodell M, 2018
Pre-transplantational Control of the Post-transplantational Fate of Human Pluripotent Stem Cell-Derived Cartilage, Lee J, Matthias N, Pothiawala A, Ang B, Lee M, Li J, Sun D, Pigeot S, Martin I, Huard J, Huang Y, Nakayama N, 2018
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance, Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao W, Dashwood R, Han L, Zhou Y, Dong W, Huang Y, 2019
Structural basis for effects of CpA modifications on C/EBPβ binding of DNA, Yang J, Horton J, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal R, Cheng X, 2018
Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition, Rajendran R, Johnson G, Li L, Chen Y, Dashwood M, Nguyen N, Ulusan A, Ertem F, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung H, Lieberman D, Beaver L, Ho E, Bedford M, Chang K, Vilar E, Dashwood R, 2019
Tet inactivation disrupts YY1 binding and long-range chromatin interactions to cause developmental defects in embryonic heart, Fang S, Li J, Xiao Y, Lee M, Han W, Li T, Hill MC, Mo W, Xu R, Wang F, Chang J, Zhou Y, Sun D, Martin JF, Huang Y, 2019
Antibiotic treatment ameliorates Ten-eleven Translocation 2 (TET2) loss-of-function associated hematological malignancies, Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang Y, 2019
A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells, Guo L, Li J, Zeng H, Guzman A, Li T, Lee M, Zhou Y, Stephan C, Davies P, Goodell M, Sun D, Dawson M, Huang Y, 2020
Integrated analysis of a compendium of RNA-Seq datasets for splicing factors, Yu P, Li Jin, Deng S, Zhang F, Grozdanov P, Chin Eunice, Martin S, Vergnes L, Islam M, Sun D, LaSalle J, McGee S, Goh E, MacDonald C, Jin P, 2020
Human pluripotent stem cell (hPSC)-derived chondroprogenitors, Nakayama N, Pothiawala A, Lee J, Matthias N, Umeda1 K, Ang B, Huard J, Huang Y, Sun D, 2020
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma, Li J, Zhao S, Lee M, Yue Y, Li J, Zhou Y, Ballester L, Esquenazi Y, Dashwood R, Davies P, Parsons D, Li X, Huang Y, Sun D, 2020
GsmPlot: a web server to visualize epigenome data in NCBI, Yin Y, Li J, Li J, Lee M, Zhao S, Guo L, Li J, Zhang M, Huang Y, Li X, Sun D, 2020
LiBis: An ultrasensitive alignment method for low-input bisulfite sequencing, Yin Y, Li J, Li J, Lee M, Zhao S, Guo L, Li J, Zhang M, Huang Y, Li X, Sun D, 2021
Genome-wide DNA methylation profiling of leukocytes identifies CpG methylation signatures of aggressive prostate cancer, Han Y, Zhang M, Xu J, Li J, Xu Y, Thompson T, Logothetis C, Sun D, Gu J, 2021
Tet2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes, Lee M, Li Jianfang, Li Jia, Fang S, Zhang J, Vo A, Han W, Zeng H, Isg
Area of Focus
Prenatal Diagnosis | Genetic Counseling | Systems Biology | Bioinformatics | Genomics | Machine Learning | Big Data | Medical Data | Disease Mechanisms | High-Throughput Sequencing
Area of Focus
Cancer | Genetics | Bioinformatics | Tumor | Genomics | Data Analysis | Computational Biology | Human Diseases | Genetic Research | Medical Informatics
