Professor | Zhanghua Yang | Asia Growth Partners

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Name	Zhanghua Yang
Contact Information	zhanghuayang@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Zhanghua Yang

Contact Information

zhanghuayang@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2016 PhD: Xiamen University Published 15 papers in international journals Total citations exceed 3200

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2016 PhD: Xiamen University
Published 15 papers in international journals
Total citations exceed 3200

Areas of Focus	Programmed Cell Death Inflammatory Response Innate Immunity
Publications	A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang ZH, Wu XN, He P, Wang X, Wu J, Ai T, Zhong CQ, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020 A ZBP1 isoform blocks ZBP1-mediated cell death, Cai ZY, Wu P, Liang H, Xie YZ, Zhang BX, He CL, Yang CR, Li H, Mo W, Yang ZH, 2024 Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity, Wu X, Yang ZH, Wu J, Han J, 2023 Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death, He P, Ai T, Qiao M, Yang ZH, Han J, 2024 Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases, Wu X, Yang ZH, Zheng Y, Wu J, Han J, 2024 Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN, Yang ZH, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J, 2014 Dual ligand engagement for noncanonical inflammasome activation, Yang ZH, Han J, 2022 Detection of necroptosis by phospho-MLKL immunohistochemical labeling, He P, Ai T, Yang ZH, Wu J, Han J, 2021 Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death, Li X, Zhang P, Yin Z, Xu F, Yang ZH, Jin J, Qu J, Liu Z, Qi H, Yao C, Shuai J, 2022 Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt, Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, Wang Y, Hu Y, Liu Y, Jia X, Yang ZH, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S, Fu G, Tang J, Han W, Chen XL, Fan W, Hong Y, Han J, Huang X, Li BA, Xiao N, Xiao C, Fu G, Liu WH, 2021 RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes, Li X, Zhong CQ, Wu R, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J, Han J, 2021 Gut stem cell necroptosis by genome instability triggers bowel inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, Han J, Mo W, 2020 Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS, Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ, 2019 RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017 Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion, He W, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015

Areas of Focus

Programmed Cell Death
Inflammatory Response
Innate Immunity

Publications

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang ZH, Wu XN, He P, Wang X, Wu J, Ai T, Zhong CQ, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020
A ZBP1 isoform blocks ZBP1-mediated cell death, Cai ZY, Wu P, Liang H, Xie YZ, Zhang BX, He CL, Yang CR, Li H, Mo W, Yang ZH, 2024
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity, Wu X, Yang ZH, Wu J, Han J, 2023
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death, He P, Ai T, Qiao M, Yang ZH, Han J, 2024
Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases, Wu X, Yang ZH, Zheng Y, Wu J, Han J, 2024
Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN, Yang ZH, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J, 2014
Dual ligand engagement for noncanonical inflammasome activation, Yang ZH, Han J, 2022
Detection of necroptosis by phospho-MLKL immunohistochemical labeling, He P, Ai T, Yang ZH, Wu J, Han J, 2021
Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death, Li X, Zhang P, Yin Z, Xu F, Yang ZH, Jin J, Qu J, Liu Z, Qi H, Yao C, Shuai J, 2022
Glycogen synthase kinase 3 drives thymocyte egress by suppressing beta-catenin activation of Akt, Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, Wang Y, Hu Y, Liu Y, Jia X, Yang ZH, Yin X, Wu J, Wu S, Zheng H, Ma X, Sun X, He Y, Lin L, Fu Y, Liao K, Zhou X, Jiang S, Fu G, Tang J, Han W, Chen XL, Fan W, Hong Y, Han J, Huang X, Li BA, Xiao N, Xiao C, Fu G, Liu WH, 2021
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes, Li X, Zhong CQ, Wu R, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J, Han J, 2021
Gut stem cell necroptosis by genome instability triggers bowel inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, Han J, Mo W, 2020
Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS, Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ, 2019
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017
Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion, He W, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015

Apoptosis Necroptosis Pyroptosis Ferroptosis Cell Signaling Immune Response Inflammation Pathophysiology Disease Prevention Molecular Mechanisms

Jiang Cao - Zhejiang University

Xin Chen - Xiamen University

Ting Wu - Xiamen University

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